FlyBase Gene Report: Dmel\kra

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\kra

General Information

Symbol

Dmel\kra

Species

D. melanogaster

Name

krasavietz

Annotation Symbol

CG2922

Feature Type

protein_coding_gene

FlyBase ID

FBgn0250753

Gene Model Status

Stock Availability

20 publicly available

Gene Summary

krasavietz (kra) encodes a translational regulator that is able to interact with the translation initiation factor encoded by eIF2β. It is involved in axon guidance, long-term memory, and alcohol addiction. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

exba, eIF-5C, l(3)03022, ECP, extra bases

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:5,595,364..5,601,136 [-]

Recombination map

3-47.5

RefSeq locus

NT_033777 REGION:5595364..5601136

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:RpL5; FB:FBgn0064225

(Wang et al., 2006)

inferred from physical interaction with FLYBASE:shot; FB:FBgn0013733

(Lee et al., 2007)

enables ribosomal small subunit binding

inferred from direct assay

(Lee et al., 2007)

enables ribosome binding

inferred from direct assay

(Wang et al., 2006)

enables translation initiation factor binding

inferred from physical interaction with FLYBASE:eIF2β; FB:FBgn0004926

(Lee et al., 2007)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in axon midline choice point recognition

inferred from mutant phenotype

(Lee et al., 2007)

involved_in behavioral response to ethanol

inferred from mutant phenotype

(Berger et al., 2008)

involved_in follicle cell of egg chamber development

inferred from mutant phenotype

(Jia et al., 2015)

involved_in long-term memory

inferred from mutant phenotype

(Akalal et al., 2011)

inferred from mutant phenotype

(Dubnau et al., 2003)

involved_in negative regulation of translation

inferred from direct assay

(Lee et al., 2007)

involved_in oogenesis

inferred from mutant phenotype

(Lee et al., 2007)

involved_in positive regulation of filopodium assembly

inferred from mutant phenotype

(Sanchez-Soriano et al., 2009)

inferred from genetic interaction with FLYBASE:shot; FB:FBgn0013733

(Sanchez-Soriano et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in long-term memory

traceable author statement

(Greenspan, 2003)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in axonal growth cone

inferred from direct assay

(Sanchez-Soriano et al., 2009)

located_in axon

inferred from direct assay

(Lee et al., 2007)

located_in cytoplasm

inferred from direct assay

(Wang et al., 2006)

located_in filopodium

inferred from direct assay

(Sanchez-Soriano et al., 2009)

located_in neuronal cell body

inferred from direct assay

(Sanchez-Soriano et al., 2009, Lee et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000368070

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the BZW family. (Q9VNE2)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

krasavietz (kra) encodes a translational regulator that is able to interact with the translation initiation factor encoded by eIF2β. It is involved in axon guidance, long-term memory, and alcohol addiction. [Date last reviewed: 2019-03-14]

Protein Function (UniProtKB)

May be involved in memory formation.

(UniProt, Q9VNE2)

Gene Model and Products

Number of Transcripts

7

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\kra for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VNE2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0078744

2123

422

FBtr0078749

1847

422

FBtr0078746

1906

422

FBtr0078748

2026

422

FBtr0078750

1701

422

FBtr0078747

1776

422

FBtr0078745

1614

422

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0078393

49.2

422

5.46

FBpp0078398

49.2

422

5.46

FBpp0078395

49.2

422

5.46

FBpp0078397

49.2

422

5.46

FBpp0078399

49.2

422

5.46

FBpp0078396

49.2

422

5.46

FBpp0078394

49.2

422

5.46

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

422 aa isoforms: kra-PA, kra-PB, kra-PC, kra-PD, kra-PE, kra-PF, kra-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q9VNE2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kra using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kra_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.10

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axonal growth cone

inferred from direct assay

(Sanchez-Soriano et al., 2009)

located_in axon

inferred from direct assay

(Lee et al., 2007)

located_in cytoplasm

inferred from direct assay

(Wang et al., 2006)

located_in filopodium

inferred from direct assay

(Sanchez-Soriano et al., 2009)

located_in neuronal cell body

inferred from direct assay

(Sanchez-Soriano et al., 2009, Lee et al., 2007)

Expression Deduced from Reporters

Reporter: P{GAL4}kra^krasavietz

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

interneuron of embryonic/larval antennal lobe

(Thum et al., 2011)

central nervous system

(Dubnau et al., 2003)

adult antennal lobe local neuron

(Chou et al., 2010)

adult antennal lobe local neuron | subset

Comment: 6-8 per antennal lobe

(Acebes et al., 2011, Das et al., 2008, Shang et al., 2007)

Kenyon cell | subset

(Chou et al., 2010, Shang et al., 2007)

GABAergic neuron | subset

(Shang et al., 2007)

cholinergic neuron | subset

(Shang et al., 2007)

GABAergic local interneuron of the adult antennal lobe | subset

Comment: 12 of 16 labeled neurons

(Chou et al., 2010)

cholinergic local interneuron of the adult antennal lobe

Comment: 6-8 per antennal lobe

(Acebes et al., 2011)

adult antennal lobe projection neuron

(Acebes et al., 2011)

lobe system of mushroom body

(Acebes et al., 2011)

mushroom body spur

(Acebes et al., 2011)

dopaminergic PPL1 neuron | subset

(Acebes et al., 2011)

adult mushroom body

(Dubnau et al., 2003)

mushroom body extrinsic neuron | subset

(Cervantes-Sandoval et al., 2016)

mushroom body pedunculus-medial lobe arborizing neuron 1

(Zhang et al., 2022)

mushroom body medial-vertical lobe arborizing neuron 1

(Zhang et al., 2022)

mushroom body vertical lobe arborizing neuron 1

(Zhang et al., 2022)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\kra in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\kra

View exonic expression by tissue for Dmel\kra

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0250753

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40680/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0250753

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0250753

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2922

Flygut - An atlas of the Drosophila adult midgut

FBgn0250753

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 37 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of kra

Transgenic constructs containing regulatory region of kra

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

(Roote, 2004.7.20)

(Ryder, 2004.4.26)

Gene not disrupted in

(Ryder and Roote, 2004.11.10)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

kra^CB02125

lethal | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

kra^GD8839

partially lethal - majority die

kra⁰³⁰²²

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

kra^GD8839

viable, with Scer\GAL4^tin.CΔ4

kra^GD8839

Sterility

Allele

female sterile | germline clone

kra¹

Other Phenotypes

Allele

abnormal memory

kra^krasavietz

abnormal neuroanatomy (with kra¹)

kra²

abnormal neuroanatomy (with kra²)

kra¹

abnormal neuroanatomy | embryonic stage (with kra¹)

kra²

abnormal neuroanatomy | embryonic stage (with kra²)

kra¹

chemical resistant

kra^krasavietz

some die during pupal stage, with Scer\GAL4^pnr-MD237

kra^GD8839

Phenotype manifest in

Allele

axon & pCC neuron (with kra¹)

kra²

axon & pCC neuron (with kra²)

kra¹

filopodium (with kra¹)

kra²

filopodium (with kra²)

kra¹

neuron (with kra¹)

kra²

neuron (with kra²)

kra¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

14 of 14

Yes

Yes

13 of 14

No

Yes

1

1 of 14

No

No

1

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

14 of 14

Yes

Yes

13 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

Mus musculus (laboratory mouse) (4)

13 of 14

Yes

Yes

13 of 14

Yes

Yes

1 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (2)

11 of 13

Yes

Yes

6 of 13

No

Yes

Danio rerio (Zebrafish) (8)

14 of 14

Yes

Yes

13 of 14

No

Yes

12 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Drer\wu:fb16f03

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP002413

11 of 12

Yes

Yes

Agam\AgaP_AGAP004750

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (4)

12 of 13

Yes

Yes

12 of 13

Yes

Yes

1 of 13

No

No

1 of 13

No

No

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

1 of 12

Yes

No

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:kra. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

alcohol, response to, learning and memory genes

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

exacerbates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^103.UAS.EGFP

(Singh et al., 2021)

exacerbates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^103.UAS.EGFP

(Singh et al., 2021)

kra^UAS.Tag:FLAG

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^103.UAS.EGFP

(Singh et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BZW1; basic leucine zipper and W2 domains 1

14 of 14

BZW2; basic leucine zipper and W2 domains 2

13 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

pull down, western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot

(Wang et al., 2006)

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

anti bait coimmunoprecipitation, Identification by mass spectrometry

(Wang et al., 2006)

anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography

(Lee et al., 2007)

two hybrid, anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography

(Lee et al., 2007)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Lee et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Carrera et al., 1998)

enhanceable

(Lee et al., 2007)

enhanceable

(Lee et al., 2007)

enhanceable

(Lee et al., 2007)

enhanceable

(Lee et al., 2007)

enhanceable

(Lee et al., 2007)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65886

DroID - A comprehensive database of gene and protein interactions.

FBgn0250753

MIST (genetic) - An integrated Molecular Interaction Database

40680

MIST (protein-protein) - An integrated Molecular Interaction Database

40680

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-47.5

Cytogenetic map

Sequence location

3R:5,595,364..5,601,136 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83B4-83B4

Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338); Limits computationally determined from genome sequence between P{PZ}Snr1⁰¹³¹⁹&P{PZ}Itp-r83A⁰⁵⁶¹⁶ and P{lacW}Atu^s1938

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

83B4-83B4

(Wan, 2000.11.30)

83B4-83B2

(determined by in situ hybridisation)

(Spradling et al., 1999)

83B1-83B5

(determined by in situ hybridisation)

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

18919

w¹¹¹⁸; PBac{WH}kra^f05932

27248

y¹ v¹; P{TRiP.JF02556}attP2

96308

y¹ w^*; P{TKO-UAS.GS05960}attP40

11581

P{PZ}kra⁰³⁰²² ry⁵⁰⁶/TM3, Sb¹

20241

y¹ w^67c23; P{EPgy2}kra^EY11022

113170

w^*; P{GawB}kra^NP3229

113372

w^*; P{GawB}kra^NP3614

125867

w¹¹¹⁸; P{RS5}kra^5-SZ-3068

2922R-1

2922R-2

v102609

P{KK102900}VIE-260B

v25166

w¹¹¹⁸; P{GD8839}v25166

More stocks available...

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (373)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD21309

Other clones

DPiM_LD21309

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0250753

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0250753

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Li et al., 2015, Lee et al., 2007, Wang et al., 2006)

monoclonal

(Wang et al., 2006)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene.

(Lee et al., 2007)

exba has a role in long-term memory.

(Dubnau et al., 2003)

exba is required for lineage specification in the nervous system.

(Lee et al., 2002)

Mutants produce extra neurons.

(Lee et al., 2002)

Relationship to Other Genes

Source for database merge of

Source for merge of: eIF-5C l(3)03022

(Levis, 2002.6.24)

Source for merge of: eIF-5C extra-bases

(Lee et al., 2003)

Source for merge of: exba l(3)j9B6

(Lee et al., 2007)

Source for merge of: eIF-5C anon-WO0172774.49

(FlyBase, 1996-)

Additional comments

Source for identity of eIF-5C CG2922 was sequence comparison ( date:010210 ).

(FlyBase, 1996-)

Source for merge of eIF-5C anon-WO0172774.49 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: eIF-5C CG2922

(FlyBase, 1996-)

Source for identity of: kra exba

(Lee et al., 2007)

Nomenclature comments

FlyBase curator comment: Originally named 'exba/extra bases' according to ADRC abstracts from the Lee group (FBrf0146421, FBrf0157123), but changed to 'kra/krasavietz' based on preference indicated in subsequently published research paper (FBrf0201378) by same group.

(Lee et al., 2007)

Etymology

Synonyms and Secondary IDs (36)

Reported As

Symbol Synonym

5MP

(Singh et al., 2021, Kozel et al., 2016)

CG2922

(Kolkhof et al., 2017, Schwartz et al., 2016, Hosono et al., 2015, Ling and Salvaterra, 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Le Mée et al., 2008, Muse et al., 2007, Quinones-Coello, 2007, Huang et al., 2005, Lee et al., 2003)

CT7240

(Ceriani et al., 2002)

Decp

(Wan, 2000.11.30)

ECP

(Wang et al., 2014, Zhao et al., 2012, Wang et al., 2006)

Ecp

(Li et al., 2015)

Exba

(Lee et al., 2007)

Kra

(Singh et al., 2021, Kaufman et al., 2020, Voelzmann et al., 2017, Carvajal-Gonzalez et al., 2016, Kaun et al., 2012, Das et al., 2010, Lee et al., 2007)

anon-WO0172774.49

chr3R:1423015..1423173

(Will et al., 2013)

eIF

(Buszczak et al., 2007)

eIF-5C

(Berger et al., 2008, Gilchrist et al., 2008, Buszczak et al., 2007, Quinones-Coello, 2007, Margulies et al., 2005, Rehwinkel et al., 2005, Bellen et al., 2004, Roote, 2004.7.20, Dubnau et al., 2003, Dubnau et al., 2003, Greenspan, 2003, Jasper et al., 2002, Levis, 2002.6.24, FlyBase, 1996-)

eIF-5c

(Hartmann et al., 2011)

eIF5

(Yu et al., 2016, Bottenberg et al., 2009)

eIF5C

(Bradley et al., 2012)

eIF5c

(Goodman et al., 2019, Devineni and Heberlein, 2010)

eIf-5c

(Ganguly-Fitzgerald et al., 2006)

ecp

(Wang et al., 2006)

eiF-5C

(Quinones-Coello, 2007)

elF-5C

(Muse et al., 2007, Ryder and Roote, 2004.11.10)

elF5C

(Sanchez-Soriano et al., 2009)

elf-5C

(Muse et al., 2007)

exba

(Deshpande et al., 2019, Stegeman et al., 2016, Jia et al., 2015, Ashwal-Fluss et al., 2014, Robinson and Atkinson, 2013, Sen et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Winbush et al., 2012, Chung et al., 2011, Ling and Salvaterra, 2011, Weake et al., 2011, Arancio et al., 2010, Bartkowiak et al., 2010, Devineni and Heberlein, 2010, Devineni and Heberlein, 2009, Perkins et al., 2009.8.10, Weake et al., 2009, Berger et al., 2008, Marygold et al., 2007)

exba/kra

(Angrisani et al., 2015)

kra

(Peng et al., 2024, Voutyraki et al., 2023, Pang et al., 2021, Gene Disruption Project members, 2018-, Park et al., 2017, Transgenic RNAi Project members, 2017-, Ables et al., 2016, Clandinin and Owens, 2016-, Kaun et al., 2012, Awofala, 2011, Bottenberg et al., 2009, Devineni and Heberlein, 2009, Sanchez-Soriano et al., 2009, Lee et al., 2007, Lee et al., 2007)

l(3)03022

(Spradling et al., 1999, Carrera et al., 1998, BDGP Project Members, 1994-1999)

l(3)j9B6

Name Synonyms

Drosophila eIF5C-containing protein

(Wan, 2000.11.30)

Krasavietz

(Marygold et al., 2017, Das et al., 2010, Devineni and Heberlein, 2010, Seki et al., 2010, Bottenberg et al., 2009, Sanchez-Soriano et al., 2009, Lee et al., 2007)

eIF5-mimic protein

(Kozel et al., 2016)

eukaryotic initiation factor 5C

extra bases

(Lee et al., 2002)

extra bses

(Hartmann et al., 2011)

extra-bases

(Lee et al., 2003)

krasavietz

(Carvajal-Gonzalez et al., 2016, Kaun et al., 2012, Awofala, 2011, Hartmann et al., 2011, Huang et al., 2010, Yaksi and Wilson, 2010, Devineni and Heberlein, 2009, Krashes et al., 2009, Berger et al., 2008, Dubnau et al., 2003)

lethal (3) j9B6

Secondary FlyBase IDs

FBgn0061514
FBgn0046382
FBgn0010791
FBgn0037346
FBgn0011418

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 79 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40680

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VNE2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VNE2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VNE2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0250753

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40680/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0250753

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0250753

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2922

MARRVEL_MODEL - MARRVEL (model organism gene)

40680

Linkouts

BioGRID - A database of protein and genetic interactions.

65886

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0250753

DroID - A comprehensive database of gene and protein interactions.

FBgn0250753

DRSC - Results frm RNAi screens

FBgn0250753

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kra_1

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0250753

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2922

Flygut - An atlas of the Drosophila adult midgut

FBgn0250753

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC030783

MIST (genetic) - An integrated Molecular Interaction Database

40680

MIST (protein-protein) - An integrated Molecular Interaction Database

40680

References (132)