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Citation
Shklover, J., Levy-Adam, F., Kurant, E. (2015). The role of Drosophila TNF Eiger in developmental and damage-induced neuronal apoptosis.  FEBS Lett. 589(8): 871--879.
FlyBase ID
FBrf0227872
Publication Type
Research paper
Abstract

Eiger, the sole Drosophila TNF-alpha homolog, causes ectopic apoptosis through JNK pathway activation. Yet, its role in developmental apoptosis remains unclear. eiger mutant flies are viable and fertile but display compromised elimination of oncogenic cells and extracellular bacteria. Here we show that Eiger, specifically expressed in embryonic neurons and glia, is not involved in developmental neuronal apoptosis or in apoptotic cell clearance. Instead, we provide evidence that Eiger is required for damage-induced apoptosis in the embryonic CNS through regulation of the pro-apoptotic gene hid independently of the JNK pathway. Our study thus reveals a new requirement for Eiger in eliminating damaged cells during development.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    FEBS Lett.
    Title
    FEBS Letters
    Publication Year
    1968-
    ISBN/ISSN
    0014-5793
    Data From Reference
    Aberrations (1)
    Alleles (9)
    Genes (6)
    Insertions (1)
    Transgenic Constructs (6)