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General Information
Symbol
P{Mhc-Switch.O}
FlyBase ID
FBtp0015154
Feature type
transgenic_transposable_element
Component Allele(s)
Also Known As
MHC-GS-GAL4, MHC-GS, MHC-GeneSwitch-Gal4, MHC-Geneswitch, MHCGS
Size
Expression Data
GAL4 reporter/driver
Associated insertion(s)
Molecular map
Description and Uses
Location-dependent role
Description
CV term
Qualifiers and info
Reference
transposon
Construct components
Component allele Scer\GAL4Mhc.Switch.PO
Product class / Tool use(s)
Regulatory region(s)
Description

A2.4kb fragment of the Mhc gene (including the promoter intron 1 and the 5'UTR exons 1 and 2) promoter drives expression of the ligand-inducible GAL4::GS driver.

Sequence Data
Sequence (FB)
Associated Sequence Data
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Features
CV term
Qualifiers and info
Reference
ligand-inducible
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Component Alleles
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

Drives mifepristone-inducible expression in larval somatic muscle.

Scer\GAL4Mhc.Switch.PO drives mifepristone-inducible expression in flight, leg, abdominal, labial, and digestive system muscles, and uninduced expression in indirect flight and leg muscles. It also exhibits uninduced expression in larval and pupal muscles.

 
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments

construct_comment: Drives expression of the "GeneSwitch" protein, an RU486-activated GAL4 fusion protein.

construct_comment: Scer\ GAL4::Hsap \ PGR::Hsap \RELA fusion (Scer\GAL4Mhc.Switch.PO) protein function induced upon application of RU486 ligand.See report for T:Hsap\PGR; see report for T:Hsap\RELA.

Stocks (1)
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (21)
References (32)