Reference Report

Reference
Citation	Sen, J., Goltz, J.S., Stevens, L., Stein, D. (1998). Spatially restricted expression of pipe in the Drosophila egg chamber defines embryonic dorsal-ventral polarity. Cell 95(4): 471--481. (Export to RIS)
FlyBase ID	FBrf0105324
Publication Type	Research paper
PubMed ID	9827800
PubMed Abstract	Expression of pipe in the somatic tissue of the Drosophila ovary is required for the formation of embryonic dorsal-ventral polarity. pipe, which encodes an enzyme similar to the glycosaminoglycan-modifying enzyme heparan sulfate 2-O-sulfotransferase, is expressed in a spatially restricted domain of follicle cells on the ventral side of the egg chamber. Mutations that affect follicular polarity correspondingly alter the spatial pattern of pipe expression. Directed expression of pipe in otherwise pipe mutant females restores embryonic lateral and ventral pattern elements and can orient the dorsal-ventral axis of the embryo. Thus, the localized expression of pipe and the spatially restricted modification of carbohydrate chains play pivotal roles in the mechanisms that establish embryonic pattern and integrate follicular and embryonic polarity.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (3)
	Df(3L)ash1^A16 Df(3L)kto2 Df(3L)pipe^A13
Alleles (16)
	Ecol\lacZ^pip.5' fs(1)K10¹ gd² grk³ grk⁶ ndl¹ ndl² pip¹ pip² pip^ST2.Scer\UAS Scer\GAL4²⁵ Scer\GAL4²⁴¹ Scer\GAL4^DE1 w^+mC wbl^RP wbl^T6
Constructs (2)
	P{pip-lacZ.5'} P{UAS-pip.ST2}
Genes (10)
	ash1 Ecol\lacZ fs(1)K10 gd grk ndl pip Scer\GAL4 w wbl
Insertions (3)
	P{GAL4}DE1 P{GawB}25 P{GawB}241