FlyBase Aberration Report: Dmel\In(1)y[3PL]sc[8R]

General Information

Symbol

In(1)y^3PLsc^8R

Species

D. melanogaster

Name

Inversion (1) yellow-3 of Patterson Left scute-8 Right

FlyBase ID

FBab0004283

Feature type

inversion_derived_deficiency_plus_aneuploid

Also Known As

Df(1)y^3PLsc^8R

Computed Breakpoints include

Sequence coordinates

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

In(1)sc⁸

(Chia et al., 1986)

In(1)y^3P

(Chia et al., 1986)

Mutagen

recombination

(Chia et al., 1986)

Class of aberration (relative to wild type)

inversion_derived_deficiency_plus_aneuploid

Class of aberration (relative to progenitor)

Breakpoints

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

Genetic mapping information

Comments

Deletes sequences encoding transcripts T5 and T6. Deficient for 25.5kb of DNA from ac-sc region (Campuzano et al., 1985)

Comments on Cytology

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

(Jimenez and Ish-Horowicz, 1997, Parras et al., 1996, Skeath and Doe, 1996, Gomez-Skarmeta et al., 1995, Ray and Rodrigues, 1994, Martinez and Modolell, 1991, Leyns et al., 1989, Alonso and Cabrera, 1988, Chia et al., 1986, del Prado and Garcia-Bellido, 1984)

(Parras et al., 1996, Skeath and Doe, 1996)

(Ray and Rodrigues, 1994, Leyns et al., 1989, Alonso and Cabrera, 1988, Chia et al., 1986)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

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Related Comments

Phenotypic Data

In combination with other aberrations

In(1)y^3PLsc^8R/Dp(1;Y)y⁺ embryos develop MP2 neuroblast normally.

(Parras et al., 1996)

NOT in combination with other aberrations

In In(1)y^3PLsc^8R homozygous embryos, a neural precursor forms the position of the MP2 cluster in wild-type 17% of the time. Roughly half of these precursors exhibit MP2-specific traits while the other half exhibit traits characteristic of other neural precursors specification of MP2.

(Wheeler et al., 2003)

Wing discs lack most sensory organ precursors.

(Nolo et al., 2000)

The rare posterior supraalar bristles that form in In(1)y^3PLsc^8R flies have normal axonal projections.

(Grillenzoni et al., 1998)

Homozygous embryos lack the MP2 neuroblast precursor. Scer\GAL4^rho.PL mediated expression of P{UAS-ac} and P{UAS-sc.P} completely restores the development of a genuine MP2 neuroblast, expression of P{UAS-ase.P} and P{UAS-l'sc} partially restores development of a MP2 neuroblast and P{UAS-ato.P} produces a transformation phenotype, dMP2 transform to vMP2 identity.

(Parras et al., 1996)

Homozygous embryos exhibit a decrease in MP2 formation due to change in MP2 identity, not a block in differentiation. MP2 formation can be rescued by expression of P{ac} or Scer\GAL4^sca-4512 mediated expression of sc^UAS.cHa, but not rescued by expression of l(1)sc^UAS.cCa.

(Skeath and Doe, 1996)

25% of glia are absent in the adult wing, compared to 50% being absent in the ac,sc double mutant, Df(1)sc10-1.

(Giangrande, 1995)

Hemizygotes show an extreme ac phenotype with respect to sensory structures on the thorax. Three of the four I-type bristles are absent from the labellum. In addition, a set of 4 or 5 additional bristles are found between the P-type and the lateral L/I-type row.

(Ray and Rodrigues, 1994)

Medial neuroblast MP2 or row B forms approximately 14% of the time, whereas the lateral neuroblast 3-5 forms less than 50% of the time.

(Skeath et al., 1994)

Hemizygous males show a very weak loss of tergite chaetae (fourth hemitergite analysed).

(Mari-Beffa et al., 1991)

Homozygous viable.

(Chia et al., 1986)

In heterozygous females the deletion acts as a dominant suppressor of h but not of emc.

(del Prado and Garcia-Bellido, 1984)

Male viable.

Stocks (2)

Kyoto

102082

In(1)y^3PLsc^8R, y^- ac^-

102060

In(1)y^3PLsc^8R, y^- ac^- ; mwh¹ hry¹

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Completely removes ac and the enhancers that drive sc expression.

(Skeath and Doe, 1996)

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Df(1)y^3PLsc^8R

(Takeuchi et al., 2007, Chu et al., 1998, Parras et al., 1996, Skeath and Doe, 1996, Gomez-Skarmeta et al., 1995, Skeath et al., 1994, Martin-Bermudo et al., 1993, Martinez and Modolell, 1991)

Dfy^3PLsc^8R

(Alonso and Cabrera, 1988)

In(1)y3P^Lsc8^R

In(1)y^3PCsc^8R

(Nolo et al., 2000)

In(1)y^3PLsc^8R

(Mari-Beffa et al., 1991)

y3PL-sc8R

(Ray and Rodrigues, 1994)

y^3PL-sc^8R

(Leyns et al., 1989)

y^3PLsc^8R

(Ohsako et al., 1994)

Name Synonyms

Inversion (1) yellow-3 of Patterson Left scute-8 Right

Secondary FlyBase IDs

References (24)

Report Sections

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