FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Acn1
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General Information
Symbol
Dmel\Acn1
Species
D. melanogaster
Name
FlyBase ID
FBal0008596
Feature type
allele
Associated gene
Dmel\Acn
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Haberman et al., 2010)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: S303term.

(Haberman et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:19,046,474..19,046,474 [+]
Nucleotide change:

C19046474A

Amino acid change:

S303term | Acn-PA; S303term | Acn-PB; S303term | Acn-PC

Reported amino acid change:

S303term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Haberman et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Acn1/Acn27 animals show a distributed lethal phase, with most larvae dying during the third instar, while some die after pupariation.

      Hemocytes isolated from Acn1/Acn27 third instar larvae appear indistinguishable from wild-type hemocytes in response to a treatment which induces apoptosis in wild-type hemocytes; the mutant hemocytes undergo nuclear condensation and chromatin fragmentation.

      Autolysosomes are fewer and less abundant, while autophagosomes are larger and more abundant in the fat body of Acn1/Acn27 third instar larvae than in control larvae after starvation.

      (Haberman et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      hkl[+]/Acn1 is an enhancer of visible | dominant phenotype of N264-39

      (Haberman et al., 2010)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      hkl[+]/Acn1 is an enhancer of wing phenotype of N264-39

      (Haberman et al., 2010)
      Suppressor of
      Statement
      Reference

      Acn27/Acn1 is a suppressor of fat body phenotype of Scer\GAL4Lsp2.PH, mTorTED.UAS

      (Haberman et al., 2010)

      Acn27/Acn1 is a suppressor of fat body phenotype of PtenUAS.cGb, Scer\GAL4Lsp2.PH

      (Haberman et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The severity of the notched wing phenotype seen in N264-39/+ flies is enhanced by Acn1/+.

      Expression of TorTED.Scer\UAS under the control of Scer\GAL4Lsp2.PH cannot induce autolysosome formation in the fat body in a Acn1/Acn27 background.

      Expression of PtenScer\UAS.cGb under the control of Scer\GAL4Lsp2.PH cannot induce autolysosome formation in the fat body in a Acn1/Acn27 background.

      (Haberman et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Acn27/Acn1 is rescued by AcnS641A.S731A.Tag:MYC

      (Nandi et al., 2014)

      Acn27/Acn1 is rescued by AcnS641D.S731D.Tag:MYC

      (Nandi et al., 2014)

      Acn27/Acn1 is rescued by AcnS641D.S731D.UAS.Tag:MYC

      (Nandi et al., 2014)

      Acn27/Acn1 is rescued by Acn+t4.2

      (Haberman et al., 2010)

      Acn27/Acn1 is rescued by Acn4.2.Tag:MYC

      (Haberman et al., 2010)
      Comments

      Acn+t4.2 and Acn4.2.T:Hsap\MYC each restore the viability of Acn1/Acn27 animals, and rescue the endocytosis and autophagy defects of Acn1/Acn27 larvae.

      (Haberman et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Wright.

      The chromosome probably carries a second-site mutation, because the lethality of Acn1/Acn27 transheterozygotes, but not of Acn1 homozygotes, can be rescued by Acn+t4.2 or by Acn4.2.T:Hsap\MYC.

      (Haberman et al., 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      Acn1
      (Nandi et al., 2014)
      acn1
      (Nandi et al., 2017)
      dacn1
      (Haberman et al., 2010)
      hkl1
      l(2)261
      l(2)37Ba1
      (Haberman et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)