FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\chic11
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General Information
Symbol
Dmel\chic11
Species
D. melanogaster
Name
FlyBase ID
FBal0028029
Feature type
allele
Associated gene
Dmel\chic
Associated Insertion(s)
P{A92}chic11
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

Mutagen
P-element activity
(Castrillon et al., 1993)
Progenitor genotype
Associated Insertion(s)
P{A92}chic11
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{A92}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      chic11/chicneo females fail to complete nurse cell dumping during oogenesis stage 13 because they are unable to form cytoplasmic actin bundles. This results in larger nurse cells and a smaller oocyte than controls.

      chic11/chicneo nurse cells have normal nucleolar structure.

      (Groen et al., 2015)

      Germline stem cell number (GSC) is significantly reduced in chic11/chic01320 mutant larval testes compared to controls. The number of GSCs is further reduced in newly eclosed adults. Somatic cells move to fill the area adjacent to the hub in the absence of GSCS.

      In contrast to wild type larval testes, where the border of the hub in contact with germline stem cells (GSCs) is concave, in chic11 the border appears more rounded.

      (Shields et al., 2014)

      The oocytes of chic11 mutants fail to accumulate G-actin or form a karyosome, which leads to the arrest of egg chamber development after stages 6-7.

      (Djagaeva et al., 2005)

      Testes with reduced germinal content.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Suppressor of
      Statement
      Reference

      chic[+]/chic11 is a suppressor of visible | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Phenotype Manifest In
      Suppressed by
      NOT suppressed by
      Suppressor of
      Statement
      Reference

      chic[+]/chic11 is a suppressor of eye | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Apc2Scer\UAS.T:Avic\GFP in germ cells under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 suppresses the germline stem cell (GSC) loss seen in chic11/chic01320 mutant testes.

      Expression of shgScer\UAS.T:Avic\GFP-rs in germ cells under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 does not suppress the germline stem cell (GSC) loss seen in chic11/chic01320 mutant testes.

      (Shields et al., 2014)

      A chic11 heterozygous background partially suppresses the rough eye phenotype seen in Fmr1sev.PW mutants.

      (Estes et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      J. Merriam.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      chi01112
      chi11
      chic11
      (Groen et al., 2015, Shields et al., 2014)
      ms(2)01112
      (Beaton, 1999.12.12)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)