FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\styUAS.cHa
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General Information
Symbol
Dmel\styUAS.cHa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Hacohen
FlyBase ID
FBal0086309
Feature type
allele
Associated gene
Dmel\sty
Associated Insertion(s)
Carried in Construct
P{UAS-sty.H}
Also Known As
UAS-spry, UAS-sty
Key Links
Transgenic product class
cDNA
(Hacohen et al., 1998)
wild_type
(Hacohen et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Hacohen et al., 1998)
wild_type
(Hacohen et al., 1998)
Mutagen
in vitro construct
(Hacohen et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-sty.H}
Cytology
Description

A 2.2kb sty cDNA fragment containing the entire coding region is expressed under the control of UASt regulatory sequences.

(Hacohen et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
sty
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      chordotonal organ, with Scer\GAL4en-e16E

      (Kramer et al., 1999)

      dorsal appendage, with Scer\GAL4T155

      (Reich et al., 1999)

      egg, with Scer\GAL4CY2

      (Kramer et al., 1999)

      egg, with Scer\GAL4T155

      (Reich et al., 1999)

      egg, with Scer\GAL4VP16.mat.αTub67C

      (Reich et al., 1999)

      embryo, with Scer\GAL4CY2

      (Kramer et al., 1999)

      embryonic/larval optic stalk surface glial cell | third instar larval stage, with Scer\GAL4repo.PL

      (Sieglitz et al., 2013)

      eye, with Scer\GAL4elav-C155

      (Kramer et al., 1999)

      eye, with Scer\GAL4GMR.PF

      (Bai et al., 2001)

      eye, with Scer\GAL4hs.2sev

      (Kramer et al., 1999)

      eye, with Scer\GAL4sev.EP

      (Mao and Freeman, 2009)

      eye photoreceptor cell, with Scer\GAL4hs.2sev

      (Jarvis et al., 2006)

      interommatidial bristle, with Scer\GAL4hs.2sev

      (Jarvis et al., 2006)

      muscle founder cell, with Scer\GAL41151

      (Dutta et al., 2005)

      NMJ bouton | third instar larval stage, with Scer\GAL4how-24B

      (Sen et al., 2011)

      ommatidium, with Scer\GAL4elav-C155

      (Kramer et al., 1999)

      ommatidium, with Scer\GAL4hs.2sev

      (Jarvis et al., 2006, Kramer et al., 1999)

      photoreceptor cell R1, with Scer\GAL4elav-C155

      (Kramer et al., 1999)

      photoreceptor cell R1, with Scer\GAL4hs.2sev

      (Kramer et al., 1999)

      photoreceptor cell R3, with Scer\GAL4elav-C155

      (Kramer et al., 1999)

      photoreceptor cell R3, with Scer\GAL4hs.2sev

      (Kramer et al., 1999)

      photoreceptor cell R4, with Scer\GAL4elav-C155

      (Kramer et al., 1999)

      photoreceptor cell R4, with Scer\GAL4hs.2sev

      (Kramer et al., 1999)

      photoreceptor cell R6, with Scer\GAL4elav-C155

      (Kramer et al., 1999)

      photoreceptor cell R6, with Scer\GAL4hs.2sev

      (Kramer et al., 1999)

      photoreceptor cell R7, with Scer\GAL4elav-C155

      (Kramer et al., 1999)

      photoreceptor cell R7, with Scer\GAL4hs.2sev

      (Kramer et al., 1999)

      wing, with Scer\GAL4BH1

      (Kramer et al., 1999)

      wing, with Scer\GAL4Bx-MS1096

      (Reich et al., 1999)

      wing vein, with Scer\GAL4BH1

      (Kramer et al., 1999)

      wing vein L2, with Scer\GAL4Bx-MS1096

      (Reich et al., 1999)

      wing vein L3, with Scer\GAL4Bx-MS1096

      (Reich et al., 1999)

      wing vein L3, with Scer\GAL4dpp.blk1

      (Reich et al., 1999)

      wing vein L4, with Scer\GAL4Bx-MS1096

      (Reich et al., 1999)
      Detailed Description
      Statement
      Reference

      Scer\GAL4repo.PL-mediated expression of styScer\UAS.cHa results in impaired glial cell wrapping in the optic stalk in larval eye discs.

      (Sieglitz et al., 2013)

      Expression of styScer\UAS.cHa driven by Scer\GAL4how-24B significantly reduces the number of boutons per muscle at the neuromuscular junction of third instar larvae, compared to controls.

      (Sen et al., 2011)

      Expression of styScer\UAS.cHa under the control of Scer\GAL4sev.EP results in a rough-eye phenotype.

      (Mao and Freeman, 2009)

      Expression of styScer\UAS.cHa under the control of Scer\GAL4hs.2sev causes misrotation and disorganization of ommatidia, missing photoreceptors in 5% of ommatidia, and external roughening of the eye.

      (Jarvis et al., 2006)

      Expression of styScer\UAS.cHa under the control of Scer\GAL41151 leads to a decrease in the number of founder cells; there are ~7 dorsal founders and ~8 lateral founders per hemisegment in Scer\GAL41151>styScer\UAS.cHa pupae, compared to 17-22 and 20 of these founder types in control pupae. However, there is no comparable change in the number of fusion-competent myoblasts.

      (Dutta et al., 2005)

      When expression is driven by Scer\GAL4GMR.PF eyes are small and rough.

      (Bai et al., 2001)

      Expression of styScer\UAS.cHa under the control of Scer\GAL4dpp.blk1 has no effect on furrow initiation in the eye disc.

      (Kumar and Moses, 2001)

      When expression is driven by Scer\GAL4hs.2sev or Scer\GAL4elav-C155 the eyes of the resulting flies are small and disorganized. Majority of ommatidia lack one or more outer photoreceptor cells of the R3/R4/R1/R6 type. The R7 is missing in 11+-4% of Scer\GAL4hs.2sev-driven ommatidia and 18+-6% of Scer\GAL4elav-C155-driven ommatidia. R2/R5 and R8 are unaffected. When expression is driven by Scer\GAL4en-e16E, the number of chordotonal organs in the embryo is reduced. When expression is driven by Scer\GAL4BH1, wing veins fail to form, and the size of the wing blade is reduced. This phenotype is similar to that caused by loss of function Egfr or vn mutants. When expression is driven by Scer\GAL4CY2, resulting eggs had a ventralized egg shell and the resulting embryos were also ventralized. This phenotype is similar to that caused by Egfr loss of function mutants.

      (Kramer et al., 1999)

      When expression is driven by Scer\GAL4mat.αTub67C.T:Hsim\VP16 the resulting phenotype resembles that caused by loss of function alleles in Egfr. When expression is driven by Scer\GAL4T155 the egg is ventralized and the dorsal appendages are fused and reduced. When expression is driven by Scer\GAL4dpp.blk1 the L3 vein of the adult wing is truncated. When expression is driven by Scer\GAL4Bx-MS1096 the L2, L3 and L4 veins of the adult wing are truncated. The size of the wing is somewhat reduced.

      (Reich et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      Scer\GAL4GMR.PF, styUAS.cHa has visible phenotype, enhanceable by edUAS.cBa/Scer\GAL4GMR.PF

      (Bai et al., 2001)
      Suppressed by
      Statement
      Reference

      Scer\GAL4GMR.PF, styUAS.cHa has visible phenotype, suppressible | partially by edlF20

      (Bai et al., 2001)
      Suppressor of
      Statement
      Reference

      styUAS.cHa, Scer\GAL471B is a suppressor of lethal phenotype of RafUAS.F179, Scer\GAL471B

      (Reich et al., 1999)
      Other
      Statement
      Reference

      RafUAS.F179, Scer\GAL471B, styUAS.cHa has visible phenotype

      (Reich et al., 1999)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of rauGD14083 further impairs the glial cell wrapping phenotype of Scer\GAL4repo.PL styScer\UAS.cHa mutants.

      (Sieglitz et al., 2013)

      The rough-eye phenotype observed in flies expressing styScer\UAS.cHa under the control of Scer\GAL4sev.EP is suppressed in the presence of Fas2EB112/+.

      (Mao and Freeman, 2009)

      When expression is driven by Scer\GAL4Bx-MS1096 in combination with btl::EgfrScer\UAS.T:λ\cI-DD, the wing size of the btl::EgfrScer\UAS.T:λ\cI-DD is largely normal and the wing veins, though still slightly thickened compared to wild type, are largely restored. When expression is driven by Scer\GAL4Bx-MS1096 in combination with htlScer\UAS.T:λ\cI-DD, the wing vein defects caused by htlScer\UAS.T:λ\cI-DD are largely suppressed. Lethality of phlScer\UAS.F179, Scer\GAL471B is rescued by styScer\UAS.cHa. Wings of phlScer\UAS.F179, styScer\UAS.cHa, Scer\GAL471B mutants are largely devoid of wing vein.

      (Reich et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      styScer\UAS.cHa
      styUAS.cHa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Hacohen
      (Hacohen et al., 1998)
      Secondary FlyBase IDs
        References (13)