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Citation
Dutta, D., Shaw, S., Maqbool, T., Pandya, H., Vijayraghavan, K. (2005). Drosophila Heartless acts with Heartbroken/Dof in muscle founder differentiation.  PLoS Biol. 3(10): e337.
FlyBase ID
FBrf0191368
Publication Type
Research paper
Abstract

The formation of a multi-nucleate myofibre is directed, in Drosophila, by a founder cell. In the embryo, founders are selected by Notch-mediated lateral inhibition, while during adult myogenesis this mechanism of selection does not appear to operate. We show, in the muscles of the adult abdomen, that the Fibroblast growth factor pathway mediates founder cell choice in a novel manner. We suggest that the developmental patterns of Heartbroken/Dof and Sprouty result in defining the domain and timing of activation of the Fibroblast growth factor receptor Heartless in specific myoblasts, thereby converting them into founder cells. Our results point to a way in which muscle differentiation could be initiated and define a critical developmental function for Heartbroken/Dof in myogenesis.

PubMed ID
PubMed Central ID
PMC1197288 (PMC) (EuropePMC)
Related Publication(s)
Review

A signaling pathway at the heart of muscle development.
Anonymous, 2005, PLoS Biol. 3(10): e358 [FBrf0200114]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS Biol.
    Title
    PLoS Biology
    Publication Year
    2003-
    ISBN/ISSN
    1545-7885 1544-9173
    Data From Reference