FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\baboQ302D.UAS
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General Information
Symbol
Dmel\baboQ302D.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0094577
Feature type
allele
Associated gene
Dmel\babo
Associated Insertion(s)
Carried in Construct
P{UAS-babo.Q302D}
Also Known As
UAS-babo*, UAS-Babo*, UAS-BABOACT, UAS-baboQD
Key Links
Transgenic product class
missense_variant
(Brummel et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Brummel et al., 1999)
Mutagen
in vitro construct
(Brummel et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-babo.Q302D}
Cytology
Description

UASt regulatory sequences drive expression of a constitutively active form of babo (carries the amino acid replacement Q302D).

(Brummel et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
babo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of baboQ302D.UAS under the control of Scer\GAL4NP1624 only during adulthood (under the additional control of Gal80{ts]) results in the progressive and complete loss of hub cells; unlike in controls, the majority of cyst stem cells and early differentiating cyst cells originated from hub cell trans-differentiation.

      (Herrera et al., 2021)

      Expression of baboQ302D.Scer\UAS in Dm8 neurons under the control of Hsim\VP16AD.VGlut.OK371.T:Zzzz\ZipEERRL,T:SV40\nls2 and Scer\GAL4DBD.ort.C2.T:Zzzz\ZipRREEL significantly reduced the dendritic field sizes as compared to wild type. As in wild type, Dm8 neurons expressing baboQ302D.Scer\UAS are routed to the M6 layer.

      (Ting et al., 2014)

      Scer\GAL4Mhc.PW-mediated expression of baboQ302D.Scer\UAS reduces the number of autophagic vacuoles within adult muscle.

      (Bai et al., 2013)

      baboQ302D.Scer\UAS expression in the imaginal wing disc using Scer\GAL4vg.MQ.Exel leads to visible adult wing defects.

      (Peterson et al., 2012)

      Expression of baboQ302D.Scer\UAS under the control of Scer\GAL4A9 produces a significant vein-patterning defect.

      (Jensen et al., 2009)

      Expression of baboQ302D.Scer\UAS using Scer\GAL4salm-459.2 modifies wing size, the pattern of veins and the integrity of the wing.

      Expression of baboQ302D.Scer\UAS using Scer\GAL4nub-AC-62 causes the differentiation of most wing cells as vein tissue.

      (Barrio et al., 2007)

      Expression of baboQ302D.Scer\UAS under the control of Scer\GAL4A9 results in substantially larger wings with proportionally normal wing patterning.

      (Gesualdi and Haerry, 2007)

      Expression of baboQ302D.Scer\UAS under the control of Scer\GAL4GMR.PF results in large eyes with patterning defects. The ommatidia in these eyes are larger than normal.

      Expression of baboQ302D.Scer\UAS under the control of Scer\GAL4en-e16E results in ectopic vein material in the posterior compartment, and the posterior compartment becomes enlarged relative to wild-type wings.

      (Ramel et al., 2007)

      When expression is driven by Scer\GAL4A9 the wing undergoes tissue overgrowth by approximately 30%, without pattern abnormalities. One of every two cells undergoes an ectopic division.

      (Brummel et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Enhancer of
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of baboQ302D.Scer\UAS under the control of Hsim\VP16AD.VGlut.OK371.T:Zzzz\ZipEERRL,T:SV40\nls2 and Scer\GAL4DBD.ort.C2.T:Zzzz\ZipRREEL suppresses the expansion of Dm neuron dendritic field size when rhabdomere R7 neurons are ablated in sev4 mutants. As in wild type the Dm8 neurons are routed to medulla layer M6.

      (Ting et al., 2014)

      Expression of baboQ302D.Scer\UAS under the control of Scer\GAL4Tab2-201Y rescues the γ neuron pruning defects seen in plumΔ1 mushroom body neuroblast clones.

      (Yu et al., 2013)

      Co-expression of MaddsRNA.Scer\UAS.cPa with baboQ302D.Scer\UAS under the control of Scer\GAL4vg.MQ.Exel suppresses the baboQ302D.Scer\UAS-induced blistered and crumpled wing phenotype and the resulting wings resemble those expressing MaddsRNA.Scer\UAS.cPa alone.

      Co-expression of SmoxdsRNA.Scer\UAS.cPa with baboQ302D.Scer\UAS under the control of Scer\GAL4vg.MQ.Exel makes the baboQ302D.Scer\UAS-induced phenotype more severe. The resulting wings are more wrinkled and shrunken than wings where either construct is expressed alone.

      Co-expression of SmoxScer\UAS.T:Zzzz\FLAG with baboQ302D.Scer\UAS under the control of Scer\GAL4vg.MQ.Exel suppresses the baboQ302D.Scer\UAS-induced blistered wing phenotype.

      (Peterson et al., 2012)

      Co-expression of SnooM67 rescues the wing phenotypes caused by Scer\GAL4salm-459.2- or Scer\GAL4nub-AC-62-mediated expression of baboQ302D.Scer\UAS.

      (Barrio et al., 2007)

      Co-expression of baboQ302D.Scer\UAS and MadScer\UAS.cNa, both under the control of Scer\GAL4A9, increases the transformation of intervein into vein tissue. Although the wing discs are larger, the adult wings are smaller due to cell death and transformation of intervein into more tightly associated vein cells.

      Co-expression of baboQ302D.Scer\UAS and four copies of SmoxScer\UAS.cGa (under the control of Scer\GAL4A9) results in a small increase in ectopic wing vein formation. No additional wing growth is observed.

      Expression of baboQ302D.Scer\UAS in a dawaact1 background under the control of the neurosecretory driver Scer\GAL4386Y fails to suppress dawaact1 lethality.

      (Gesualdi and Haerry, 2007)

      Co-expression of SnooEP2510 strongly suppresses both the overgrowth and patterning defects seen in the eyes of flies expressing baboQ302D.Scer\UAS under the control of Scer\GAL4GMR.PF.

      Co-expression of SnooEP2510 significantly suppresses the ectopic wing vein and overgrowth phenotypes that are seen in the posterior compartment of the wing in flies expressing baboQ302D.Scer\UAS under the control of Scer\GAL4en-e16E.

      (Ramel et al., 2007)

      The addition of baboQ302D.Scer\UAS (driven by Scer\GAL4ptc-559.1) suppresses the head phenotype seen in ptc559.1, Df(2R)Np3. None of these animals exhibit head capsule defects.

      (Shyamala and Bhat, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      BaboCA
      (Moss-Taylor et al., 2019)
      baboQ302D.Scer\UAS
      baboQ302D.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (28)