FlyBase Allele Report: Dmel\mir-bft[24]

General Information

Symbol

Dmel\mir-bft²⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0137299

Feature type

allele

Associated gene

Dmel\mir-bft

Associated Insertion(s)

Carried in Construct

Also Known As

bft²⁴, bereft²⁴

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Hilgers et al., 2010)

Mutagen

Delta2-3 transposase

(Hardiman et al., 2002)

Progenitor genotype

P{lacW}E8-2-46

(Hardiman et al., 2002)

Cytology

Description

Imprecise excision of the P{lacW} element, resulting in a 2.8kb deletion that removes sequences both proximal and distal to the site of the P{lacW} insertion, including the first exon and 1.5kb of intron 1 of bft.

(Hardiman et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cystic fibrosis

CEA with mir-bft^Δ263a

(Kim et al., 2017)

model of neurodegenerative disease

CEA with mir-bft^Δ263a-G4

(Aw et al., 2017)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased occurrence of cell division | adult stage (with mir-bft^Δ263a)

(Kim et al., 2017)

lethal (with Df(2L)prd1.7)

(Hardiman et al., 2002)

partially lethal (with Df(2L)esc10)

(Hardiman et al., 2002)

partially lethal (with Df(2L)esc-P3-0)

(Hardiman et al., 2002)

partially lethal (with mir-bft⁶)

(Hardiman et al., 2002)

partially lethal (with mir-bft⁹⁷)

(Hardiman et al., 2002)

partially lethal (with mir-bft¹¹⁶)

(Hardiman et al., 2002)

partially lethal (with mir-bft¹²²)

(Hardiman et al., 2002)

partially lethal (with mir-bft²²⁵)

(Hardiman et al., 2002)

partially lethal (with mir-bft²²⁷)

(Hardiman et al., 2002)

partially lethal | recessive

(Hardiman et al., 2002)

visible (with mir-bft^Δ263a)

(Hilgers et al., 2010)

visible (with mir-bft^Δ263a-G4)

(Hilgers et al., 2010)

Phenotype Manifest In

adult midgut (with mir-bft^Δ263a)

(Kim et al., 2017)

adult posterior midgut epithelium (with mir-bft^Δ263a)

(Kim et al., 2017)

dorsocentral bristle

(Hardiman et al., 2002)

humeral bristle

(Hardiman et al., 2002)

interommatidial bristle

(Hardiman et al., 2002)

interommatidial bristle (with Df(2L)esc10)

(Hardiman et al., 2002)

interommatidial bristle (with Df(2L)esc-P3-0)

(Hardiman et al., 2002)

interommatidial bristle (with mir-bft⁶)

(Hardiman et al., 2002)

interommatidial bristle (with mir-bft⁹⁷)

(Hardiman et al., 2002)

interommatidial bristle (with mir-bft¹¹⁶)

(Hardiman et al., 2002)

interommatidial bristle (with mir-bft²²⁵)

(Hardiman et al., 2002)

interommatidial bristle (with mir-bft²²⁷)

(Hardiman et al., 2002)

interommatidial bristle (with mir-bft^Δ263a)

(Hilgers et al., 2010)

interommatidial bristle (with mir-bft^Δ263a-G4)

(Hilgers et al., 2010)

interommatidial bristle & socket

(Hardiman et al., 2002)

orbital bristle

(Hardiman et al., 2002)

postocellar bristle

(Hardiman et al., 2002)

scutellar bristle

(Hardiman et al., 2002)

sensillum trichodeum & trichogen cell

(Hardiman et al., 2002)

trichoid sensillum

(Hardiman et al., 2002)

vertical bristle

(Hardiman et al., 2002)

Detailed Description

Statement

Reference

The adult posterior midguts of bft^Δ263a/bft²⁴ transheterozygotes display a significant increase in the number of mitotic cells at 14 days post eclosion, as compared to controls.

(Kim et al., 2017)

bft^Δ263a/bft²⁴ flies show loss of approximately 80% of interommatidial bristles.

bft^Δ263a-G4/bft²⁴ flies show loss of interommatidial bristles.

(Hilgers et al., 2010)

45% of the expected number of homozygotes survive. Mutant adults lack 50-90% of the interommatidial bristles and in most cases, severely defective structures are seen where the interommatidial bristles normally form. The sockets may be abnormal. Third instar mutant larvae often have abnormal trichoid sensilla in which the shaft is missing.

(Hardiman et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

mir-bft²⁴/mir-bft^Δ263a has visible phenotype, enhanceable by Df(3L)X-21.2/mir-263b^Δ

(Hilgers et al., 2010)

Suppressed by

Statement

Reference

mir-bft²⁴/mir-bft^Δ263a has visible phenotype, suppressible by Scer\GAL4^{mir-263b-Δ-G4}/mir-263b^UAS.DsRed2

(Hilgers et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

mir-bft²⁴/mir-bft^Δ263a has interommatidial bristle phenotype, enhanceable by Df(3L)X-21.2/mir-263b^Δ

(Hilgers et al., 2010)

Suppressed by

Statement

Reference

mir-bft²⁴/mir-bft^Δ263a has interommatidial bristle phenotype, suppressible by Scer\GAL4^{mir-263b-Δ-G4}/mir-263b^UAS.DsRed2

(Hilgers et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

The loss of interommatidial bristles seen in bft^Δ263a/bft²⁴ flies is significantly enhanced if the flies are also carrying mir-263b^Δ/Df(3L)X-21.2.

Expression of mir-263b^{Scer\UAS.T:Disc\RFP-DsRed2} under the control of Scer\GAL4^{mir-263b-Δ-G4} rescues the loss of interommatidial bristles which is seen in bft^Δ263a/bft²⁴ flies.

(Hilgers et al., 2010)

ct^K/+ ; bft⁶/bft²⁴ females can survive to adulthood and they show the bft mutant eye phenotype. Adult ct^K/Y ; bft⁶/bft²⁴ males are never seen.

(Hardiman et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

mir-bft²⁴/mir-bft^Δ263a-G4 is rescued by Scer\GAL4^{mir-bft-Δ263a-G4}/mir-bft^UAS.DsRed2

(Hilgers et al., 2010)

Partially rescued by

mir-bft²⁴/mir-bft^Δ263a is partially rescued by mir-bft^UAS.DsRed2

(Hilgers et al., 2010)

Comments

Expression of bft^{Scer\UAS.T:Disc\RFP-DsRed2} under the control of Scer\GAL4^{bft-Δ263a-G4} rescues the loss of interommatidial bristles which is seen in bft^Δ263a-G4/bft²⁴ flies.

Leaky expression of bft^{Scer\UAS.T:Disc\RFP-DsRed2} in the absence of a Scer\GAL4 driver partially rescues the loss of interommatidial bristles which is seen in bft^Δ263a/bft²⁴ flies.

(Hilgers et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

bereft²⁴

(Nian et al., 2019, Hilgers et al., 2010)

bft²⁴

(Touré et al., 2025, Wu et al., 2019, Aw et al., 2017, Kim et al., 2017, Hilgers et al., 2010)

mir-bft²⁴

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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