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General Information
Symbol
Dmel\peloUASp.cXa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Xi
FlyBase ID
FBal0191293
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UASp-pelo, UAS-pelo
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASp regulatory sequences drive expression of pelo. The pelo sequence corresponds to the AT07625 clone.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expressing peloUASp.cXa under the control of Scer\GAL4VP16.nos.UTR fully rescues the male sterility and spermatogenesis defects (male germline stem cell number, individualization complex formation and spermatid nuclei elongation defects) observed in peloPB60/pelo1 transheterozygotes.

The near complete sterility (minimal number of laid eggs, very low hatching rate) of pelo1/peloPB60 transheterozygous females can be partially rescued by expression of peloScer\UAS.P\T.cXa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 in the mutant background. Expression under the Scer\GAL4nos.UTR.T:Hsim\VP16 driver rescues the spermatogenesis defects (no individualization complexes and waste bags) as well as the male sterility, which can also bes rescued by Scer\GAL4αTub84B.PL-driven expression.

Expression of peloScer\UAS.P\T.cXa under the control of Scer\GAL4da.PU suppresses the resistance of peloΔ homozygous mutants to the Drosophila C virus, rendering them sensitive to the infection.

The GSC loss phenotype in pelo1 females is partially rescued by leaky expression of the peloScer\UAS.P\T.cXa transgene without a driver; expression driven by Scer\GAL4C587 in the somatic cells of the germarium confers very limited extra rescue compared to that conferred by the transgene alone.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
peloScer\UAS.P\T.cXa
peloUASp.cXa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Xi
Secondary FlyBase IDs
    References (6)