Open Close
General Information
Symbol
Dmel\foxoBG01018
Species
D. melanogaster
Name
FlyBase ID
FBal0194180
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
BG01018
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A P{GT1} insertion roughly 130 nucleotides upstream of the transcriptional start site of the foxo gene.

Insertion components
P{GT1}foxoBG01018
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

foxoBG01018/foxo21 and foxoBG01018/foxo25 flies display a 4.8% improvement in medial survival following M.marinum infection in comparison to wild-type flies - 174 hours vs. 166 hours. The number of bacteria recorded in these flies is not significantly different from wild-type flies. However, the rate of glycogen loss is significantly slowed in infected foxoBG01018/foxo25 flies compared to wild-type flies, so that disease-induced wasting is reduced in the foxoBG01018/foxo25 mutants.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Suppressor of
Statement
Reference
NOT Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The ability of 0.5mM Psammaplysene A to suppress the eye degeneration phenotype caused by expression of Hsap\ARQ52.Scer\UAS under the control of Scer\GAL4GMR.PU (in the presence of dihydrotestosterone) is suppressed if the flies are also heterozygous for foxoBG01018.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)