FlyBase Allele Report: Dmel\foxo[BG01018]

General Information

Symbol

Dmel\foxo^BG01018

Species

D. melanogaster

Name

FlyBase ID

FBal0194180

Feature type

allele

Associated gene

Dmel\foxo

Associated Insertion(s)

P{GT1}foxo^BG01018

Carried in Construct

Also Known As

BG01018

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Dionne et al., 2006)

Mutagen

P-element activity

(Dionne et al., 2006)

Progenitor genotype

Associated Insertion(s)

P{GT1}foxo^BG01018

Cytology

Description

A P{GT1} insertion roughly 130 nucleotides upstream of the transcriptional start site of the foxo gene.

(Dionne et al., 2006)

Allele components

Component

Use(s)

Inserted element

P{GT1}

gene trap

polyA trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:14,056,857..14,056,857 [+]

(Slack et al., 2011, Dionne et al., 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response (with foxo²¹)

(Dionne et al., 2006)

abnormal immune response (with foxo²⁵)

(Dionne et al., 2006)

Phenotype Manifest In

Detailed Description

Statement

Reference

foxo^BG01018/foxo²¹ and foxo^BG01018/foxo²⁵ flies display a 4.8% improvement in medial survival following M.marinum infection in comparison to wild-type flies - 174 hours vs. 166 hours. The number of bacteria recorded in these flies is not significantly different from wild-type flies. However, the rate of glycogen loss is significantly slowed in infected foxo^BG01018/foxo²⁵ flies compared to wild-type flies, so that disease-induced wasting is reduced in the foxo^BG01018/foxo²⁵ mutants.

(Dionne et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

foxo^BG01018 is a non-enhancer of abnormal starvation stress response phenotype of BG02257^BG02257

(Rollmann et al., 2006)

foxo^BG01018 is a non-enhancer of abnormal starvation stress response phenotype of BG02514^BG02514

(Rollmann et al., 2006)

foxo^BG01018 is a non-enhancer of short lived phenotype of BG02514^BG02514

(Rollmann et al., 2006)

Suppressor of

Statement

Reference

foxo^BG01018 is a suppressor of long lived | female phenotype of BG02257^BG02257

(Rollmann et al., 2006)

foxo^BG01018 is a suppressor of long lived | male phenotype of BG02257^BG02257

(Rollmann et al., 2006)

NOT Suppressor of

Statement

Reference

foxo^BG01018 is a non-suppressor of abnormal starvation stress response phenotype of BG02257^BG02257

(Rollmann et al., 2006)

foxo^BG01018 is a non-suppressor of abnormal starvation stress response phenotype of BG02514^BG02514

(Rollmann et al., 2006)

foxo^BG01018 is a non-suppressor of short lived phenotype of BG02514^BG02514

(Rollmann et al., 2006)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The ability of 0.5mM Psammaplysene A to suppress the eye degeneration phenotype caused by expression of Hsap\AR^Q52.Scer\UAS under the control of Scer\GAL4^GMR.PU (in the presence of dihydrotestosterone) is suppressed if the flies are also heterozygous for foxo^BG01018.

(Mojsilovic-Petrovic et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

12530

w¹¹¹⁸; P{GT1}foxo^BG01018

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

BG01018

(Rollmann et al., 2006)

Foxo^BG01018

(Zhang et al., 2010)

foxo¹

(Rollmann et al., 2006)

foxo^BG01018

(Mojsilovic-Petrovic et al., 2009, Dionne et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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