FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\CrtcUAS.cWa
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General Information
Symbol
Dmel\CrtcUAS.cWa
Species
D. melanogaster
Name
FlyBase ID
FBal0256964
Feature type
allele
Associated gene
Dmel\Crtc
Associated Insertion(s)
Carried in Construct
P{UAS-TORC.W}
Also Known As
UAS-Crtc
Key Links
Transgenic product class
wild_type
(Wang et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wang et al., 2008)
Mutagen
in vitro construct
(Wang et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-TORC.W}
Cytology
Description

UASt regulatory sequences drive expression of Crtc coding sequences.

(Wang et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Crtc
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      CrtcUAS.cWa, Scer\GAL4GMR.PF has eye phenotype, enhanceable by AktGD1361, Scer\GAL4GMR.PF

      (Wang et al., 2008)
      Suppressed by
      Statement
      Reference

      CrtcUAS.cWa, Scer\GAL4GMR.PF has eye phenotype, suppressible by Df(1)N19

      (Wang et al., 2008)

      CrtcUAS.cWa, Scer\GAL4GMR.PF has eye phenotype, suppressible by CrebBS162

      (Wang et al., 2008)
      NOT suppressed by
      Statement
      Reference

      CrtcUAS.cWa, Scer\GAL4GMR.PF has eye phenotype, non-suppressible by foxo25/foxo21

      (Wang et al., 2008)
      Enhancer of
      Statement
      Reference

      CrtcUAS.cWa, Scer\GAL4GMR.PF is an enhancer of eye phenotype of Pp2B-14Dact.UAS, Scer\GAL4GMR.PF

      (Wang et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Df(1)N19 or CrebB-17AS162 background suppresses the rough eye phenotype found in TORCScer\UAS.cWa-expressing (under the control of Scer\GAL4GMR.PF) flies.

      Depletion of Akt1 through expression of Akt1GD1361 in TORCScer\UAS.cWa-expressing developing eyes (both lines under the control of Scer\GAL4GMR.PF) enhances the TORC-mediated rough eye phenotype.

      Over-expression of TORCScer\UAS.cWa strongly potentiates the effects of Pp2B-14Dact.Scer\UAS expression on eye morphology.

      TORCScer\UAS.cWa over-expressing flies (driven by Scer\GAL4GMR.PF) in which foxo is reduced or eliminated though a foxo25/foxo21 background still exhibit a rough eye phenotype.

      (Wang et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      CrtcUAS.cWa/Scer\GAL4AD.elav rescues Crtc25-3

      (Wang et al., 2008)
      Fails to rescue

      CrtcUAS.cWa/Scer\GAL4r4 fails to rescue Crtc25-3

      (Wang et al., 2008)
      Comments

      Pan-neuronal expression of TORCScer\UAS.cWa under the control of Scer\GAL4AD.elav.T:Zzzz\ZipEERRL,T:SV40\nls2 rescues both the starvation- and paraquat-sensitive phenotypes of TORC25-3 mutant flies. In keeping with this, total lipid levels are elevated in rescued flies. However, lipid levels are only partially restored.

      TORCScer\UAS.cWa expression in the fat body under the control of Scer\GAL4r4 does not rescue the starvation sensitivity seen in TORC25-3 mutant flies.

      (Wang et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      CrtcScer\UAS.cWa
      CrtcUAS.cWa
      TORCScer\UAS.cWa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)