FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Est-P
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General Information
Symbol
Dmel\Est-P
Species
D. melanogaster
Name
Esterase P
Annotation Symbol
CG17148
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000594
Gene Model Status
Current
Stock Availability
4 publicly available
Enzyme Name (EC)
carboxylesterase (3.1.1.1)
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

yEst-6, ΨEst-6, EstP, Est-7

Key Links
Genomic Location
Cytogenetic map
69A1-69A1
Sequence location
Recombination map
3-38
RefSeq locus
NT_037436 REGION:12190733..12192528
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (2 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables carboxylesterase activity
inferred from direct assay
(Dumancic et al., 1997)
enables serine hydrolase activity
inferred from high throughput direct assay
(Kumar et al., 2021)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the type-B carboxylesterase/lipase family. (P18167)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
carboxylesterase activity
a carboxylic ester + H2O = an alcohol + a carboxylate + H(+) (3.1.1.1)
RHEA 21164:
Summaries
Gene Group (FlyBase)
CARBOXYLESTERASES -
Carboxylesterases catalyze the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H(+).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Est-P for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry P18167)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Est-P-RA
FBtr0076004
NM_176323
1740
544
Additional Transcript Data and Comments
Reported size (kB)

1.92, 1.25 (northern blot)

(Collet et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Est-P-PA
FBpp0075736
61.1
544
6.79
P18167
NP_788501
AAF49945
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

544 (aa)

(Collet et al., 1990)
Comments
External Data
Subunit Structure (UniProtKB)

Monomer.

(UniProt, P18167)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Est-P using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.20

Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
organism
(Collet et al., 1990)
adult stage
(Collet et al., 1990)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Est-P in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 29 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Est-P
Transgenic constructs containing regulatory region of Est-P
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3L)Exel6116
(Ryder, 2004.4.26)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (20)
Hsap\CES1
6 of 14
Yes
No
Hsap\CES2
6 of 14
Yes
No
Hsap\CES3
6 of 14
Yes
Yes
Hsap\CES4A
6 of 14
Yes
No
Hsap\CES5A
6 of 14
Yes
No
Hsap\CEL
5 of 14
No
Yes
Hsap\ACHE
4 of 14
No
No
3  
Hsap\NLGN1
3 of 14
No
No
4  
Hsap\NLGN2
3 of 14
No
No
Hsap\NLGN3
3 of 14
No
No
2  
Hsap\NLGN4X
3 of 14
No
No
Hsap\AADAC
2 of 14
No
No
Hsap\AADACL2
2 of 14
No
No
Hsap\AADACL3
2 of 14
No
No
Hsap\AADACL4
2 of 14
No
No
Hsap\BCHE
2 of 14
No
No
3  
Hsap\CES1P1
2 of 14
No
Yes
Hsap\NCEH1
2 of 14
No
No
Hsap\NLGN4Y
2 of 14
No
No
Hsap\TG
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (39)
Rnor\Ces2j
7 of 14
Yes
No
Rnor\Ces1a
6 of 14
No
No
Rnor\Ces1f
6 of 14
No
No
Rnor\Ces2e
6 of 14
No
No
Rnor\Ces2g
6 of 14
No
No
Rnor\Ces2h
6 of 14
No
No
Rnor\Ces4a
6 of 14
No
No
Rnor\Ces5a
6 of 14
No
No
Rnor\LOC679149
6 of 14
No
No
Rnor\Cel
5 of 14
No
Yes
Rnor\Ces1c
5 of 14
No
No
Rnor\Ces1d
5 of 14
No
No
Rnor\Ces2a
5 of 14
No
No
Rnor\Ces2c
5 of 14
No
No
Rnor\Ces2i
5 of 14
No
No
Rnor\RGD1561236
5 of 14
No
No
Rnor\Ces1e
4 of 14
No
No
Rnor\Cesl1
3 of 14
No
No
Rnor\Ache
2 of 14
No
No
Rnor\Bche
2 of 14
No
No
Rnor\Ces2
2 of 14
No
Yes
Rnor\LOC688542
2 of 14
No
No
Rnor\Nlgn1
2 of 14
No
No
Rnor\Nlgn2
2 of 14
No
No
Rnor\Nlgn3
2 of 14
No
No
Rnor\Aadacl2
1 of 14
No
No
Rnor\Aadacl3
1 of 14
No
No
Rnor\Aadacl4
1 of 14
No
No
Rnor\Aadac
1 of 14
No
No
Rnor\LOC691196
1 of 14
No
No
Rnor\Nceh1
1 of 14
No
No
Rnor\RGD1308878
1 of 14
No
No
Rnor\RGD1559622
1 of 14
No
No
Rnor\RGD1559644
1 of 14
No
No
Rnor\RGD1560162
1 of 14
No
No
Rnor\RGD1560324
1 of 14
No
No
Rnor\RGD1561998
1 of 14
No
No
Rnor\RGD1563334
1 of 14
No
No
Rnor\Tg
1 of 14
No
No
Mus musculus (laboratory mouse) (39)
Mmus\Ces2a
7 of 14
Yes
Yes
Mmus\Ces1a
6 of 14
No
No
Mmus\Ces1b
6 of 14
No
No
Mmus\Ces1c
6 of 14
No
No
Mmus\Ces1d
6 of 14
No
No
Mmus\Ces1e
6 of 14
No
No
Mmus\Ces1f
6 of 14
No
No
Mmus\Ces1g
6 of 14
No
No
Mmus\Ces1h
6 of 14
No
No
Mmus\Ces2b
6 of 14
No
No
Mmus\Ces2c
6 of 14
No
No
Mmus\Ces2e
6 of 14
No
No
Mmus\Ces2f
6 of 14
No
No
Mmus\Ces2g
6 of 14
No
No
Mmus\Ces2h
6 of 14
No
No
Mmus\Ces3a
6 of 14
No
No
Mmus\Ces3b
6 of 14
No
No
Mmus\Ces4a
6 of 14
No
No
Mmus\Ces5a
5 of 14
No
No
Mmus\Cel
4 of 14
No
No
Mmus\Ache
3 of 14
No
No
Mmus\Nlgn1
3 of 14
No
No
Mmus\Nlgn2
3 of 14
No
No
Mmus\Nlgn3
3 of 14
No
No
Mmus\Bche
2 of 14
No
No
Mmus\Aadacl2fm1
1 of 14
No
No
Mmus\Aadacl2fm2
1 of 14
No
No
Mmus\Aadacl2fm3
1 of 14
No
No
Mmus\Aadacl2
1 of 14
No
No
Mmus\Aadacl3
1 of 14
No
No
Mmus\Aadacl4fm1
1 of 14
No
No
Mmus\Aadacl4fm2
1 of 14
No
No
Mmus\AAdacl4fm3
1 of 14
No
No
Mmus\Aadacl4fm4
1 of 14
No
No
Mmus\Aadacl4fm5
1 of 14
No
No
Mmus\Aadacl4
1 of 14
No
No
Mmus\Aadac
1 of 14
No
No
Mmus\Nceh1
1 of 14
No
No
Mmus\Tg
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (20)
Xtro\bche
3 of 13
Yes
No
Xtro\ces3.1
3 of 13
Yes
Yes
Xtro\aadacl3
2 of 13
No
Yes
Xtro\aadacl4
2 of 13
No
Yes
Xtro\aadac
2 of 13
No
Yes
Xtro\ache
2 of 13
No
No
Xtro\bchel
2 of 13
No
No
Xtro\cel.2
2 of 13
No
Yes
Xtro\nceh1
2 of 13
No
Yes
Xtro\acaa1
1 of 13
No
No
Xtro\angptl3
1 of 13
No
No
Xtro\dmd.3
1 of 13
No
No
Xtro\LOC100492444
1 of 13
No
Yes
Xtro\LOC100493994
1 of 13
No
No
Xtro\nlgn1
1 of 13
No
No
Xtro\nlgn3
1 of 13
No
No
Xtro\nlgn4x
1 of 13
No
No
Xtro\palm2akap2
1 of 13
No
Yes
Xtro\ptgr2
1 of 13
No
No
Xtro\unc93a.2
1 of 13
No
No
Danio rerio (Zebrafish) (23)
Drer\cel.2
5 of 14
Yes
Yes
Drer\ces3
5 of 14
Yes
No
Drer\cel.1
4 of 14
No
No
Drer\ces2a
4 of 14
No
No
Drer\ache
3 of 14
No
No
Drer\nlgn2a
3 of 14
No
No
Drer\nlgn2b
3 of 14
No
No
Drer\nlgn3b
3 of 14
No
No
Drer\nlgn4xa
3 of 14
No
No
Drer\ces2b
2 of 14
No
No
Drer\LOC100334697
2 of 14
No
No
Drer\nlgn1
2 of 14
No
No
Drer\nlgn3a
2 of 14
No
No
Drer\nlgn4xb
2 of 14
No
No
Drer\si:ch211-71n6.4
2 of 14
No
No
Drer\si:dkey-30c15.17
2 of 14
No
No
Drer\aadac
1 of 14
No
No
Drer\aadacl4
1 of 14
No
No
Drer\LOC797436
1 of 14
No
No
Drer\nceh1a
1 of 14
No
No
Drer\nceh1b.1
1 of 14
No
No
Drer\si:dkey-193c22.1
1 of 14
No
No
Drer\tg
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (48)
Cele\cest-19
6 of 14
Yes
Yes
Cele\cest-25
6 of 14
Yes
No
Cele\cest-26
6 of 14
Yes
No
Cele\cest-32
6 of 14
Yes
No
Cele\cest-35.1
6 of 14
Yes
No
Cele\cest-35.2
6 of 14
Yes
No
Cele\ges-1
6 of 14
Yes
No
Cele\cest-1.2
5 of 14
No
Yes
Cele\cest-2.3
5 of 14
No
Yes
Cele\cest-17
5 of 14
No
No
Cele\cest-27
5 of 14
No
No
Cele\cest-28
5 of 14
No
No
Cele\cest-30
5 of 14
No
No
Cele\cest-31
5 of 14
No
No
Cele\cest-33
5 of 14
No
No
Cele\cest-34
5 of 14
No
No
Cele\cest-1.1
4 of 14
No
Yes
Cele\cest-2.1
4 of 14
No
Yes
Cele\cest-5.2
4 of 14
No
Yes
Cele\cest-8
4 of 14
No
Yes
Cele\cest-9.1
4 of 14
No
Yes
Cele\cest-9.2
4 of 14
No
Yes
Cele\cest-10
4 of 14
No
Yes
Cele\cest-16
4 of 14
No
No
Cele\cest-24
4 of 14
No
No
Cele\ace-1
3 of 14
No
No
Cele\ace-3
3 of 14
No
No
Cele\ace-4
3 of 14
No
No
Cele\cest-2.2
3 of 14
No
Yes
Cele\cest-3
3 of 14
No
Yes
Cele\cest-4
3 of 14
No
Yes
Cele\cest-5.1
3 of 14
No
Yes
Cele\cest-6
3 of 14
No
Yes
Cele\cest-12
3 of 14
No
No
Cele\cest-13
3 of 14
No
Yes
Cele\ace-2
2 of 14
No
No
Cele\cest-7
2 of 14
No
Yes
Cele\cest-15
2 of 14
No
Yes
Cele\F16F9.4
2 of 14
No
No
Cele\glit-1
2 of 14
No
No
Cele\nceh-1
2 of 14
No
Yes
Cele\T09B9.1
2 of 14
No
No
Cele\trcs-1
2 of 14
No
No
Cele\B0238.13
1 of 14
No
No
Cele\F13H6.4
1 of 14
No
No
Cele\T28C12.5
1 of 14
No
No
Cele\Y71G12B.28
1 of 14
No
Yes
Cele\ZK994.1
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (48)
Agam\COEBE1D
12 of 12
Yes
Yes
Agam\COEBE2D
12 of 12
Yes
Yes
Agam\COEBE3D
11 of 12
No
Yes
Agam\COEBE4D
11 of 12
No
Yes
Agam\AgaP_AGAP005756
6 of 12
No
Yes
Agam\AgaP_AGAP006227
6 of 12
No
No
Agam\AgaP_AGAP006228
6 of 12
No
No
Agam\COEAE1A
6 of 12
No
Yes
Agam\AgaP_AGAP001722
5 of 12
No
No
Agam\AgaP_AGAP002391
5 of 12
No
No
Agam\AgaP_AGAP005758
5 of 12
No
No
Agam\AgaP_AGAP005834
5 of 12
No
No
Agam\AgaP_AGAP005837
5 of 12
No
No
Agam\AgaP_AGAP006723
5 of 12
No
No
Agam\AgaP_AGAP006724
5 of 12
No
No
Agam\AgaP_AGAP006726
5 of 12
No
No
Agam\AgaP_AGAP006727
5 of 12
No
No
Agam\AgaP_AGAP006728
5 of 12
No
No
Agam\COEAE2E
5 of 12
No
No
Agam\COEAE3H
5 of 12
No
No
Agam\COEAE6O
5 of 12
No
No
Agam\COEAE8O
5 of 12
No
No
Agam\COEJHE1F
5 of 12
No
No
Agam\COEJHE3F
5 of 12
No
No
Agam\COEJHE4F
5 of 12
No
No
Agam\AgaP_AGAP001101
4 of 12
No
No
Agam\AgaP_AGAP003570
3 of 12
No
No
Agam\AgaP_AGAP011507
3 of 12
No
Yes
Agam\AgaP_AGAP011509
3 of 12
No
Yes
Agam\AgaP_AGAP011575
3 of 12
No
Yes
Agam\AgaP_AGAP013509
3 of 12
No
No
Agam\ACES_ANOGA
2 of 12
No
No
Agam\AgaP_AGAP000466
2 of 12
No
No
Agam\AgaP_AGAP002090
2 of 12
No
No
Agam\AgaP_AGAP003115
2 of 12
No
No
Agam\AgaP_AGAP006956
2 of 12
No
No
Agam\AgaP_AGAP010390
2 of 12
No
No
Agam\AgaP_AGAP010911
2 of 12
No
No
Agam\AgaP_AGAP010917
2 of 12
No
No
Agam\AgaP_AGAP011365
2 of 12
No
No
Agam\AgaP_AGAP011366
2 of 12
No
No
Agam\AgaP_AGAP003568
1 of 12
No
No
Agam\AgaP_AGAP005644
1 of 12
No
No
Agam\AgaP_AGAP008190
1 of 12
No
No
Agam\AgaP_AGAP010912
1 of 12
No
No
Agam\AgaP_AGAP010913
1 of 12
No
No
Agam\AgaP_AGAP010914
1 of 12
No
No
Agam\AgaP_AGAP011916
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (23)
Atha\AT1G19190
2 of 13
Yes
No
Atha\AT1G49650
2 of 13
Yes
No
Atha\AT1G68620
2 of 13
Yes
No
Atha\AT2G45600
2 of 13
Yes
No
Atha\AT2G45610
2 of 13
Yes
No
Atha\AT3G27320
2 of 13
Yes
No
Atha\CXE5
2 of 13
Yes
No
Atha\CXE13
2 of 13
Yes
No
Atha\CXE16
2 of 13
Yes
No
Atha\CXE17
2 of 13
Yes
No
Atha\CXE18
2 of 13
Yes
No
Atha\CXE20
2 of 13
Yes
No
Atha\GID1A
2 of 13
Yes
No
Atha\GID1B
2 of 13
Yes
No
Atha\ICME-LIKE1
2 of 13
Yes
No
Atha\AT1G47480
1 of 13
No
No
Atha\AT1G49640
1 of 13
No
No
Atha\AT2G03550
1 of 13
No
No
Atha\AT5G06570
1 of 13
No
No
Atha\CXE12
1 of 13
No
No
Atha\GID1C
1 of 13
No
No
Atha\ICME-LIKE2
1 of 13
No
No
Atha\PCME
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\SAY1
1 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\SPCC417.12
5 of 12
Yes
No
Spom\SPAC8F11.08c
1 of 12
No
Yes
Spom\SPAC1039.03
1 of 12
No
No
Spom\SPAPB1A11.02
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Est-P. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (35)
Est-6
13 of 13
CG4757
10 of 13
α-Est8
9 of 13
CG3841
9 of 13
CG4382
9 of 13
Est17
9 of 13
Jhedup
9 of 13
Jhe
9 of 13
α-Est1
8 of 13
α-Est2
8 of 13
α-Est4
8 of 13
α-Est6
8 of 13
α-Est7
8 of 13
α-Est9
8 of 13
α-Est10
8 of 13
CG6414
8 of 13
clt
8 of 13
gas
8 of 13
α-Est3
7 of 13
α-Est5
7 of 13
Est-Q
7 of 13
CG5397
6 of 13
CG9287
5 of 13
Gli
5 of 13
Ace
4 of 13
CG9289
4 of 13
CG10339
4 of 13
Nlg1
4 of 13
Nlg4
3 of 13
CG12869
2 of 13
Nlg2
2 of 13
Nlg3
2 of 13
Nrt
2 of 13
CG30095
1 of 13
Glt
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    CEL; carboxyl ester lipase
    model of  maturity-onset diabetes of the young type 8
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CES1; carboxylesterase 1
    6 of 14
    114835
      CES2; carboxylesterase 2
      6 of 14
      605278
          CES3; carboxylesterase 3
          6 of 14
          605279
              CES4A; carboxylesterase 4A
              6 of 14
              621153
                  CES5A; carboxylesterase 5A
                  6 of 14
                  618678
                      CEL; carboxyl ester lipase
                      5 of 14
                      114840
                      ACHE; acetylcholinesterase (Yt blood group)
                      4 of 14
                      100740
                         
                        NLGN1; neuroligin 1
                        3 of 14
                        NEUROLIGIN 1; NLGN1
                           
                          NLGN2; neuroligin 2
                          3 of 14
                          606479
                              NLGN3; neuroligin 3
                              3 of 14
                              300336
                                 
                                NLGN4X; neuroligin 4 X-linked
                                3 of 14
                                300427
                                  Functional Complementation Data
                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                  Interactions
                                  Summary of Physical Interactions
                                  Interaction Browsers
                                  Summary of Genetic Interactions
                                  Interaction Browsers
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  Starting gene(s)
                                  Interaction type
                                  Interacting gene(s)
                                  Reference
                                  External Data
                                  Subunit Structure (UniProtKB)
                                  Monomer.
                                  (UniProt, P18167 )
                                  Linkouts
                                  DroID - A comprehensive database of gene and protein interactions.
                                  Pathways
                                  Signaling Pathways (FlyBase)
                                  Metabolic Pathways
                                  FlyBase
                                  External Links
                                  FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                                  KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                  Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                  External Data
                                  Linkouts
                                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                  Class of Gene
                                  Genomic Location and Detailed Mapping Data
                                  Chromosome (arm)
                                  3L
                                  Recombination map
                                  3-38
                                  Cytogenetic map
                                  69A1-69A1
                                  Sequence location
                                  FlyBase Computed Cytological Location
                                  Cytogenetic map
                                  Evidence for location
                                  69A1-69A1
                                  Limits computationally determined from genome sequence between P{PZ}rols08232&P{lacW}l(3)j2D3j2D3 and P{PZ}l(3)0508805088
                                  Experimentally Determined Cytological Location
                                  Cytogenetic map
                                  Notes
                                  References
                                  69A-69A
                                  (determined by in situ hybridisation)
                                  (Segarra et al., 1996)
                                  69A1-69A1
                                  (determined by in situ hybridisation)
                                  (Oakeshott et al., 1993)
                                  Experimentally Determined Recombination Data
                                  Location

                                  3-38

                                  (FlyBase, 2016)

                                  3-30.9

                                  (Comeron et al., 2012)

                                  3-35.9

                                  Left of (cM)
                                  Right of (cM)
                                  Notes
                                  Stocks and Reagents
                                  Stocks (4)
                                  Genomic Clones (13)
                                   

                                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                  cDNA Clones (2)
                                   

                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                  cDNA clones, fully sequenced
                                  BDGP DGC clones
                                  Other clones
                                  Drosophila Genomics Resource Center cDNA clones

                                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                  cDNA Clones, End Sequenced (ESTs)
                                  BDGP DGC clones
                                    Other clones
                                      RNAi and Array Information
                                      Linkouts
                                      DRSC - Results frm RNAi screens
                                      Antibody Information
                                      Laboratory Generated Antibodies
                                       
                                      Commercially Available Antibodies
                                       
                                      Cell Line Information
                                      Publicly Available Cell Lines
                                       
                                        Other Stable Cell Lines
                                         
                                          Other Comments

                                          The more recently acquired site of Est-6 activity, the anterior ejaculatory duct, is directed by distal sequences lying both 5' and 3' of the coding region. The 3' sequences appear to lie within the transcription unit of the adjacent Est-P gene.

                                          (Healy et al., 1996)

                                          Chromosome homologies of Muller's element D (J chromosome in the Paleartic species and XR chromosome arm in Nearctic species) and of element E (O chromosome in the Paleartic species and 2 chromosome in Nearctic species) have been confirmed by single copy probes in the species of the obscura group and in D.melanogaster.

                                          (Segarra et al., 1996)

                                          The sequences of the Dpse\Est-5A, Dpse\Est-5B and Dpse\Est-5C genes, and the D.melanogaster Est-6 and Est-P genes have been compared.

                                          (Brady and Richmond, 1992)

                                          The Est-6 and Est-P genes, which are arranged as a tandem repeat, have been cloned and sequenced.

                                          (Collet et al., 1990)
                                          Relationship to Other Genes
                                          Source for database merge of
                                          Additional comments
                                          Nomenclature History
                                          Source for database identify of

                                          Source for identity of: Est-P CG17148

                                          (Li, 1999.11)
                                          Nomenclature comments
                                          Etymology
                                          Synonyms and Secondary IDs (15)
                                          Reported As
                                          Symbol Synonym
                                          CG17148
                                          (Ni et al., 2010.12.1)
                                          EST-5
                                          (Bondinas et al., 2001)
                                          EST7
                                          (Dumancic et al., 1997)
                                          ESTP
                                          (Oakeshott et al., 1993)
                                          Est-5
                                          (Segarra et al., 1996)
                                          Est-7
                                          (Balakirev et al., 2005, Balakirev and Ayala, 2004, Balakirev and Ayala, 2003)
                                          Est-P
                                          (Torabi-Marashi et al., 2025, Kumar et al., 2021, Matthews et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Weake et al., 2008, Yi et al., 2008, Balakirev et al., 2005, Balakirev and Ayala, 2004, Bochdanovits and de Jong, 2004)
                                          Est7
                                          (Robin et al., 2009)
                                          EstP
                                          (Robin et al., 2009, Dumancic et al., 1997, Game and Oakeshott, 1990)
                                          est-P
                                          (Pen et al., 1990)
                                          yEst-6
                                          (Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 2002.7.5, Balakirev, 1999.5.13, Balakirev, 1999.5.13, Balakirev, 1999.5.13, Balakirev, 1999.5.13, Balakirev, 1999.5.13, Balakirev, 1999.5.13, Balakirev, 1999.5.13)
                                          yEst6
                                          (Morrell et al., 2006)
                                          ΨEst-6
                                          (Balakirev and Ayala, 2004, Balakirev and Ayala, 2003, Balakirev et al., 2003, Balakirev et al., 1999)
                                          ψEst-6
                                          (Balakirev et al., 2006, Balakirev et al., 2005, Balakirev and Ayala, 2003)
                                          Name Synonyms
                                          Esterase P
                                          Secondary FlyBase IDs
                                          • FBgn0017620
                                          Datasets (0)
                                          Study focus (0)
                                          Experimental Role
                                          Project
                                          Project Type
                                          Title
                                          Study result (0)
                                          Result
                                          Result Type
                                          Title
                                          External Crossreferences and Linkouts ( 125 )
                                          Sequence Crossreferences
                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                          Other crossreferences
                                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                          FlyMine - An integrated database for Drosophila genomics
                                          InterPro - A database of protein families, domains and functional sites
                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                          MARRVEL_MODEL - MARRVEL (model organism gene)
                                          Linkouts
                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                          DroID - A comprehensive database of gene and protein interactions.
                                          DRSC - Results frm RNAi screens
                                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                                          Flygut - An atlas of the Drosophila adult midgut
                                          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                          KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                          Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                          References (83)