FlyBase Gene Report: Dmel\Nlg3

General Information

Symbol

Dmel\Nlg3

Species

D. melanogaster

Name

Neuroligin 3

Annotation Symbol

CG34127

Feature Type

protein_coding_gene

FlyBase ID

FBgn0083963

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

Neuroligin 3 (Nlg3) encodes a synaptic adhesion molecule involved in synapse formation and synaptic transmission. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

dnlg3

Key Links

Genomic Location

Cytogenetic map

84D10-84D11

Sequence location

3R:7,570,281..7,639,434 [-]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:7570281..7639434

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables neurexin family protein binding

inferred from biological aspect of ancestor with PANTHER:PTN000168538

(GO Reference Genome Project, 2011-)

enables signaling receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000168538

(GO Reference Genome Project, 2011-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in neuromuscular junction development

inferred from mutant phenotype

(Xing et al., 2014)

involved_in synaptic vesicle endocytosis

inferred from mutant phenotype

(Xing et al., 2014)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

involved_in chemical synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN000168538

(GO Reference Genome Project, 2011-)

involved_in modulation of chemical synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN000168538

(GO Reference Genome Project, 2011-)

involved_in neuron cell-cell adhesion

inferred from biological aspect of ancestor with PANTHER:PTN000168538

(GO Reference Genome Project, 2011-)

involved_in postsynaptic membrane assembly

inferred from biological aspect of ancestor with PANTHER:PTN000168538

(GO Reference Genome Project, 2011-)

involved_in presynaptic membrane assembly

inferred from biological aspect of ancestor with PANTHER:PTN000168538

(GO Reference Genome Project, 2011-)

involved_in synaptic vesicle endocytosis

inferred from biological aspect of ancestor with PANTHER:PTN000168538

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in cell surface

inferred from biological aspect of ancestor with PANTHER:PTN000168538

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000168538

(GO Reference Genome Project, 2011-)

is_active_in postsynaptic membrane

inferred from biological aspect of ancestor with PANTHER:PTN002889381

(GO Reference Genome Project, 2011-)

is_active_in synapse

inferred from biological aspect of ancestor with PANTHER:PTN000168538

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Neuroligin 3 (Nlg3) encodes a synaptic adhesion molecule involved in synapse formation and synaptic transmission. [Date last reviewed: 2019-03-14]

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Nlg3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VIC6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.46

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Nlg3-RB

FBtr0301072

NM_001043220

5640

1159

Nlg3-RC

FBtr0333927

NM_169190

6650

1159

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Nlg3-PB

FBpp0290294

125.2

1159

8.30

FBpp0306055

125.2

1159

8.30

Q9VIC6

NP_731170

AAF54000

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1159 aa isoforms: Nlg3-PB, Nlg3-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VIC6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Nlg3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34127_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.49

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Nlg3 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Nlg3

View exonic expression by tissue for Dmel\Nlg3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40912/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0083963

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0083963

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0083963

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32465

Flygut - An atlas of the Drosophila adult midgut

FBgn0083963

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Nlg3

Transgenic constructs containing regulatory region of Nlg3

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Nlg3-Def1

(Yost et al., 2020)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^how-24B

Nlg3^UAS.cXa

lethal, with Scer\GAL4^insc-Mz1407

Nlg3^GD5568

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Nlg3^GD5568

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Nlg3^GD5568

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

Nlg3^GD2847

viable, with Scer\GAL4^pnr-MD237

Nlg3^GD2847

viable, with Scer\GAL4^tin.CΔ4

Nlg3^GD2847

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage

abnormal locomotor behavior | adult stage (with Nlg3^KO88)

Nlg3^KO127

abnormal locomotor behavior | adult stage (with Nlg3^KO127)

Nlg3^KO88

abnormal locomotor behavior | adult stage | recessive

Nlg3^KO127

abnormal locomotor behavior | third instar larval stage

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

Nlg3^GD5568

abnormal neuroanatomy | third instar larval stage

Nlg3^KO127

abnormal neuroanatomy | third instar larval stage, with Nlg3^KO127, Scer\GAL4^how-24B

abnormal neuroanatomy | third instar larval stage, with Nlg3^UAS.cXa, Scer\GAL4^how-24B

Nlg3^KO127

abnormal neuroanatomy | third instar larval stage, with Nlg3^Δ10.UAS, Scer\GAL4^how-24B

Nlg3^KO127

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^how-24B

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^Mhc.PU

Nlg3^UAS.cXa

abnormal neuroanatomy | third instar larval stage (with Nlg3^f00777)

abnormal neuroanatomy | third instar larval stage (with Nlg3^KO88)

Nlg3^f00777

abnormal neuroanatomy | third instar larval stage (with Nlg3^KO127)

Nlg3^f00777

abnormal neurophysiology | third instar larval stage

Nlg3^KO127

abnormal neurophysiology | third instar larval stage (with Nlg3^f00777)

Nlg3^KO88

abnormal neurophysiology | third instar larval stage (with Nlg3^KO88)

Nlg3^f00777

some die during larval stage, with Scer\GAL4^how-24B

Nlg3^UAS.cXa

some die during pupal stage, with Scer\GAL4^pnr-MD237

Nlg3^GD5568

visible, with Scer\GAL4^pnr-MD237

Nlg3^GD5568

Phenotype manifest in

Allele

embryonic/larval neuromuscular junction | third instar larval stage

Nlg3^KO127

embryonic/larval neuromuscular junction | third instar larval stage, with Nlg3^KO127, Scer\GAL4^how-24B

embryonic/larval neuromuscular junction | third instar larval stage, with Nlg3^UAS.cXa, Scer\GAL4^how-24B

Nlg3^KO127

embryonic/larval neuromuscular junction | third instar larval stage, with Nlg3^Δ10.UAS, Scer\GAL4^how-24B

Nlg3^KO127

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^how-24B

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^Mhc.PU

Nlg3^UAS.cXa

embryonic/larval neuromuscular junction | third instar larval stage (with Nlg3^f00777)

embryonic/larval neuromuscular junction | third instar larval stage (with Nlg3^KO88)

Nlg3^f00777

embryonic/larval neuromuscular junction | third instar larval stage (with Nlg3^KO127)

Nlg3^f00777

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

Nlg3^GD5568

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

Nlg3^GD5568

mesonotum, with Scer\GAL4^pnr-MD237

Nlg3^GD5568

NMJ bouton | increased number | third instar larval stage

Nlg3^KO127

NMJ bouton | third instar larval stage, with Nlg3^KO127, Scer\GAL4^how-24B

NMJ bouton | third instar larval stage, with Nlg3^UAS.cXa, Scer\GAL4^how-24B

Nlg3^KO127

NMJ bouton | third instar larval stage, with Nlg3^Δ10.UAS, Scer\GAL4^how-24B

Nlg3^KO127

NMJ bouton | third instar larval stage, with Scer\GAL4^how-24B

postsynaptic density (with Nlg3^f00777)

Nlg3^KO88

postsynaptic density (with Nlg3^KO88)

Nlg3^f00777

synaptic vesicle (with Nlg3^f00777)

Nlg3^KO88

synaptic vesicle (with Nlg3^KO88)

Nlg3^f00777

trichogen cell, with Scer\GAL4^pnr-MD237

Nlg3^GD5568

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\NLGN2

12 of 14

Yes

Hsap\NLGN1

11 of 14

Yes

Hsap\NLGN3

11 of 14

Yes

Hsap\NLGN4X

11 of 14

Yes

Hsap\NLGN4Y

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (24)

Rnor\Nlgn2

11 of 14

Yes

Rnor\Nlgn3

11 of 14

Yes

Rnor\Nlgn1

10 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (26)

Mmus\Nlgn2

12 of 14

Yes

Mmus\Nlgn3

11 of 14

Yes

Mmus\Nlgn1

10 of 14

Yes

Mmus\Nlgn4l

6 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\nlgn3

9 of 13

Yes

Xtro\nlgn4x

9 of 13

Yes

Xtro\nlgn1

8 of 13

Yes

Xtro\nlgn2

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\tg

1 of 13

Danio rerio (Zebrafish) (15)

Drer\nlgn2b

13 of 14

Yes

Drer\nlgn2a

12 of 14

Yes

Drer\nlgn1

11 of 14

Yes

Drer\nlgn3b

11 of 14

Yes

Drer\nlgn4xa

11 of 14

Yes

Drer\nlgn3a

10 of 14

Yes

Drer\nlgn4xb

10 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-193c22.1

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (43)

Cele\nlg-1

11 of 14

Yes

4 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\ZK994.1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (48)

Agam\AgaP_AGAP003568

12 of 12

Yes

Agam\AgaP_AGAP003115

5 of 12

Agam\AgaP_AGAP011916

5 of 12

Yes

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (3)

Atha\ICME-LIKE1

1 of 13

Yes

Atha\ICME-LIKE2

1 of 13

Yes

Atha\PCME

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\SPCC417.12

2 of 12

Yes

Spom\SPAC8F11.08c

1 of 12

Yes

Spom\SPAPB18E9.04c

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Nlg3. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (35)

Nlg4

8 of 13

Nlg2

7 of 13

Nlg1

6 of 13

Gli

5 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

gas

3 of 13

Jhe

3 of 13

Ace

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

clt

1 of 13

Glt

1 of 13

Nrt

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

autism spectrum disorder, susceptibility to, NLGN-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Nlg3^KO127

model of autism spectrum disorder

CEA with Nrx-1^Δ83

(Guangming et al., 2023)

CEA with Nlg2^KO70

(Guangming et al., 2023)

Nlg3^UAS.cYa

model of autism spectrum disorder

CEA

(Yost et al., 2020)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

12 of 14

11 of 14

AUTISM, SUSCEPTIBILITY TO, 20; AUTS20

NLGN3; neuroligin 3

11 of 14

300336

AUTISM, SUSCEPTIBILITY TO, X-LINKED 1; AUTSX1

NLGN4X; neuroligin 4 X-linked

11 of 14

300427

AUTISM, SUSCEPTIBILITY TO, X-LINKED 2; AUTSX2

NLGN4Y; neuroligin 4 Y-linked

10 of 14

400028

CEL; carboxyl ester lipase

3 of 14

114840

MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 8, WITH EXOCRINE DYSFUNCTION; MODY8

maturity-onset diabetes of the young type 8

CES1; carboxylesterase 1

3 of 14

114835

DRUG METABOLISM, ALTERED, CES1-RELATED

CES2; carboxylesterase 2

3 of 14

605278

CES5A; carboxylesterase 5A

3 of 14

618678

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0083963

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

84D10-84D11

Sequence location

3R:7,570,281..7,639,434 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

84D10-84D11

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-44.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

85630

w¹¹¹⁸; PBac{WH}Nlg3^f01797

82936

y¹ v¹; P{SAM.dCas9.GS05201}attP40

58509

y¹ w^*; Mi{MIC}Nlg3^MI08924

22322

y¹ w^67c23; P{EPgy2}Nlg3^EY13244

18367

w¹¹¹⁸; PBac{WH}Nlg3^f00777/TM6B, Tb¹

1062R-1

1062R-2

14597R-2

14597R-6

HMJ21950

y¹ v¹; P{TRiP.HMJ21950}attP40/CyO

VDRC

v100376

P{KK106100}VIE-260B

v102055

P{KK110531}VIE-260B

More stocks available...

Genomic Clones (48)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

IP18510

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0083963

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0083963

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Yost et al., 2020)

monoclonal

(Xing et al., 2014)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

(Claridge-Chang et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG1062 CG18291

(FlyBase Genome Annotators, 2006, FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG1062 and CG18291 merged as CG32465 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2006, FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Nlg3 CG34127

(Xing et al., 2014)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

CG1062

(Llamusi et al., 2013)

CG14597

CG18291

(Claridge-Chang et al., 2001)

CG32465

(Fukuoh et al., 2014, Ma et al., 2006, Stroschein-Stevenson et al., 2006, Ringrose et al., 2003)

CG34127

(Hosono et al., 2015, Ashwal-Fluss et al., 2014, Xing et al., 2014, Li et al., 2013, Hazelett et al., 2012, Izutsu et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Mozer and Sandstrom, 2012, Rodriguez et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

DNLG3

(Mozer and Sandstrom, 2012)

DNlg3

(Li et al., 2013)

Nlg-3

(Harris and Littleton, 2015)

Nlg3

(Smith et al., 2024, Corthals et al., 2023, Marcogliese et al., 2022, Salim et al., 2021, Mariano et al., 2020, Bellosta and Soldano, 2019, Ueoka et al., 2019, Li-Kroeger et al., 2018, Transgenic RNAi Project members, 2017-, Gene Disruption Project members, 2016-)

dnlg3

(Wu et al., 2018, Liu et al., 2017, Xing et al., 2014)

neuroligin

(Kamimura and Maeda, 2021)

nlg3

(Gunderson et al., 2021, Guangming et al., 2020, Yost et al., 2020)

Name Synonyms

Drosokinin receptor

(Pollock et al., 2003)

Neuroligin 3

neuroligin3

(Xing et al., 2014)

Secondary FlyBase IDs

FBan0032465
FBgn0037507
FBgn0037508
FBgn0037509
FBgn0052465

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 33 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40912

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

BF492337

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VIC6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VIC6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VIC6

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40912/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0083963

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0083963

FlyMine - An integrated database for Drosophila genomics

FBgn0083963

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34127

MARRVEL_MODEL - MARRVEL (model organism gene)

40912

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0083963

DroID - A comprehensive database of gene and protein interactions.

FBgn0083963

DRSC - Results frm RNAi screens

FBgn0083963

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34127_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0083963

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0083963

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32465

Flygut - An atlas of the Drosophila adult midgut

FBgn0083963

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0083963

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033028

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (68)

The following external sites may use different assemblies or annotations than FlyBase.

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