frs, fruhstart, DMZ60MEX
Gene model reviewed during 5.44
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
18 (kD observed); 10.5 (kD predicted)
Component of the Frs-CycA-Cdk1 complex composed of Z600, CycA and Cdk1. Interacts preferentially with CycA (via C-terminus) but is also able to interact (via C-terminus) with CycE (via C-terminus).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Z600 using the Feature Mapper tool.
Z600 transcripts are detected starting at embryonic cycle 13. Transcripts initially accumulate uniformly, but become concentrated in the dorsal and posterior regions during cellularization, and persist in the dorsal regions of the embryo during gastrulation and germ band extension. No signal is detected after germ band extension.
The 18 kD Z600 protein is detected at low levels in 0-2 hr embryos and at higher levels in 2-4 hr embryos. No expression is detected in older embryos or in unfertilized eggs. Immunolocalization experiments reveal that expression is found only in nuclear cycle 11-13 embryos, associated with condensed chromatin. Protein is not detected at later stages, despite the presence of Z600 transcript.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Z600 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Z600 frs
Z600 controls the cell cycle pause after precisely thirteen mitoses in embryos.
In embryos lacking Z600 function, cells in the ventral domain enter mitosis too early, causing a defective ventral furrow.
The pattern of Z600 protein expression during early embryogenesis has been determined.
Member of cluster of genes that includes Eip28/29 and gdl. Believed to play role in processes of early development.