DNApol-α50, DNA polymerase α, DNApol-alpha50, Dpri50, pol α
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Heterodimer of a catalytic subunit Prim1 and a regulatory subunit Prim2, also known as the DNA primase complex (PubMed:6403945, PubMed:6409898). Component of the alpha DNA polymerase complex (also known as the alpha DNA polymerase-primase complex) consisting of four subunits: the catalytic subunit PolA1, the regulatory subunit PolA2, and the primase complex subunits Prim1 and Prim2 respectively (PubMed:6773966, PubMed:6403945, PubMed:6409898). PolA1 associates with the DNA primase complex before association with PolA2 (PubMed:6409898).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Prim1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Prim1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Prim1 DNApol-α50
Source for merge of: DNApol-α50 anon-WO0140519.257
Source for merge of DNApol-α50 anon-WO0140519.257 was sequence comparison ( date:051113 ).
Subunits of DNA polymerase α and δ are purified from embryos and characterised.
The properties of the DNA polymerase α enzyme have been studied.
25bp DNA oligomer containing m4T is used in a gel extension assay to measure the efficiency of incorporation of dATP and dGTP opposite m4T using a DNA polymerase α-primase complex. The DNA polymerase α shows a clear preference for pairing with dGTP.