FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Fer2LCH
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General Information
Symbol
Dmel\Fer2LCH
Species
D. melanogaster
Name
Ferritin 2 light chain homologue
Annotation Symbol
CG1469
Feature Type
protein_coding_gene
FlyBase ID
FBgn0015221
Gene Model Status
Current
Stock Availability
30 publicly available
Gene Summary
Ferritin 2 light chain homologue (Fer2LCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer2LCH provides iron nucleation sites in the internal cavity of the complex required for iron mineralization and is essential for embryogenesis. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)neo63, l(3)neo60, l(3)00035, FerLCH

Key Links
Genomic Location
Cytogenetic map
99F2-99F2
Sequence location
Recombination map
3-100
RefSeq locus
NT_033777 REGION:30387804..30390584
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables ferrous iron binding
inferred from direct assay
(Georgieva et al., 1999)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ferric iron binding
inferred from biological aspect of ancestor with PANTHER:PTN000153092
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001519, InterPro:IPR008331
(InterPro Project Members, 2004-)
enables ferrous iron binding
inferred from biological aspect of ancestor with PANTHER:PTN000153092
(GO Reference Genome Project, 2011-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in detoxification of iron ion
inferred from mutant phenotype
(Tang and Zhou, 2013)
involved_in intracellular iron ion homeostasis
inferred from direct assay
(Georgieva et al., 1999)
involved_in iron ion import across plasma membrane
inferred from mutant phenotype
(Tang and Zhou, 2013)
involved_in response to fungus
inferred from high throughput expression pattern
(Levy et al., 2004)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in intracellular iron ion homeostasis
inferred from electronic annotation with InterPro:IPR001519
(InterPro Project Members, 2004-)
involved_in iron ion transport
inferred from electronic annotation with InterPro:IPR001519
(InterPro Project Members, 2004-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in extracellular region
inferred from high throughput direct assay
(Karlsson et al., 2004)
part_of ferritin complex
inferred from direct assay
(Georgieva et al., 1999)
located_in Golgi apparatus
inferred from direct assay
(Missirlis et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000153092
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ferritin family. (Q9VA83)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Ferritin 2 light chain homologue (Fer2LCH) encodes one of two subunits of the major iron storage complex, the ferritin molecule. In insects, ferritin is assembled from 12 Fer1HCH and 12 Fer2LCH subunits and can be found in the secretory pathway of cells and in hemolymph. The product of Fer2LCH provides iron nucleation sites in the internal cavity of the complex required for iron mineralization and is essential for embryogenesis. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
FERRITINS -
Ferritins (FER) function as main iron storage proteins and regulate iron homeostasis. Cytoplasmic ferritin is a heteropolymer of heavy and light chain subunits encoded by Fer1HCH and Fer2LCH, respectively. Mitochondrial ferritin exists as a homopolymer of Fer3HCH proteins. Heavy chain homologs (Fer1HCH and Fer3HCH) have ferroxidase activity, essential for the incorporation of iron into the ferritin shell. Light chain homologs (Fer2LCH) play a role in the nucleation of the ferritin iron cores. (Adapted from FBrf0190848 and PMID:20230873).
Protein Function (UniProtKB)
Stores iron in a soluble, non-toxic, readily available form (By similarity) (PubMed:23771129). Important for iron homeostasis (By similarity) (PubMed:23064556, PubMed:23771129). Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity) (PubMed:17603097, PubMed:23771129). Ferritin is composed of a heavy (H) chain which is responsible for the oxidation and uptake of ferrous iron, and a light (L) chain which facilitates the nucleation of the ferrihydrite iron core (PubMed:23771129). Required for dietary iron absorption in the midgut (PubMed:23064556). Involved in tissue iron detoxification by exporting excess iron (PubMed:23064556). Plays a role in the maintenance of circadian rhythms (PubMed:22885802). Required for embryo and larval development (PubMed:26192321).
(UniProt, Q9VA83)
Summary (Interactive Fly)

iron storage proteins; ferroxidase and iron core nucleation- combines three functions: iron storage, intercellular iron transport, and protection from iron-induced oxidative stress

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Fer2LCH for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VA83)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Fer2LCH-RA
FBtr0085622
NM_080063
1284
227
Fer2LCH-RB
FBtr0085623
NM_170483
1443
227
Fer2LCH-RC
FBtr0085624
NM_170484
1078
227
Fer2LCH-RD
FBtr0332168
NM_001276176
1091
227
Fer2LCH-RE
FBtr0332169
NM_001276177
1118
236
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Fer2LCH-PA
FBpp0084986
25.2
227
6.30
Q9VA83
NP_524802
AAF57038
Fer2LCH-PB
FBpp0084987
25.2
227
6.30
Q9VA83
NP_733362
AAN14228
Fer2LCH-PC
FBpp0084988
25.2
227
6.30
Q9VA83
NP_733363
AAN14229
Fer2LCH-PD
FBpp0304477
25.2
227
6.30
Q9VA83
NP_001263105
AGB96484
Fer2LCH-PE
FBpp0304478
26.2
236
6.51
A0A0B4KHF0
NP_001263106
AGB96485
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

227 aa isoforms: Fer2LCH-PA, Fer2LCH-PB, Fer2LCH-PC, Fer2LCH-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Oligomer of 12 light (L) chains and 12 heavy (H) chains; L and H chains are disulfide-linked (PubMed:9266686). The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble ferric iron core is deposited (PubMed:23771129).

(UniProt, Q9VA83)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fer2LCH using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.62

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4
embryo | ubiquitous
(Missirlis et al., 2007)
embryonic stage 4 -- 6
organism | ubiquitous

Comment: apically cleared

(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
crystal cell primordium

Comment: reported as crystal cell specific anlage

(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 11
mesoderm
(Missirlis et al., 2007)
embryonic/larval plasmatocyte of embryonic head
(Missirlis et al., 2007)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
procrystal cell
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 12 -- 14
fat body primordium
(Missirlis et al., 2007)
amnioserosa
(Missirlis et al., 2007)
embryonic stage 13 -- 16
embryonic/larval crystal cell
(Fisher et al., 2012)
embryonic/larval garland cell
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic/larval plasmatocyte
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 15 -- 17
embryonic/larval midgut
(Missirlis et al., 2007)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male & day 3 of adulthood
adult head
(Metzendorf and Lind, 2010)
adult thorax
(Metzendorf and Lind, 2010)
testis
(Metzendorf and Lind, 2010)
adult Malpighian tubule
(Metzendorf and Lind, 2010)
adult gut
(Metzendorf and Lind, 2010)
Additional Descriptive Data

Fer2LCH is enriched about two-fold in the gut and Malpighian tubules.

(Metzendorf and Lind, 2010)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
adult stage | female
adult hemolymph
(Zeng et al., 2016)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
located_in extracellular region
inferred from high throughput direct assay
(Karlsson et al., 2004)
part_of ferritin complex
inferred from direct assay
(Georgieva et al., 1999)
located_in Golgi apparatus
inferred from direct assay
(Missirlis et al., 2007)
Expression Deduced from Reporters
Reporter: P{GawB}Fer2LCHNP4763
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval iron accumulating cell
(Redhai et al., 2020)
Reporter: PBac{544.SVS-1}Fer2LCHCPTI100064
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
medulla
(Knowles-Barley, 2011.8.24)
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Fer2LCH in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 45 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Fer2LCH
Transgenic constructs containing regulatory region of Fer2LCH
Aberrations (Deficiencies and Duplications) ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4repo.PU
lethal | recessive
lethal - all die before end of first instar larval stage
partially lethal - majority die, with Scer\GAL4NP3084
partially lethal - majority die | nutrition conditional, with Scer\GAL4NP3084
partially lethal - majority live | nutrition conditional, with Scer\GAL4NP3084
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal circadian rhythm, with Scer\GAL4nrv2.PS
abnormal circadian rhythm, with Scer\GAL4repo
abnormal developmental rate | first instar larval stage
abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4elav-C155
abnormal locomotor rhythm, with Scer\GAL4cry.PE
abnormal locomotor rhythm, with Scer\GAL4cry.PZ
abnormal locomotor rhythm, with Scer\GAL4elav-C155
abnormal locomotor rhythm, with Scer\GAL4Mai179
abnormal locomotor rhythm, with Scer\GAL4tim.PE
decreased occurrence of cell division | larval stage
increased cell death | embryonic stage
some die during embryonic stage
some die during first instar larval stage
Phenotype manifest in
Allele
axon | embryonic stage
embryonic/larval cuticle | embryonic stage
embryonic/larval cuticle | embryonic stage | germline clone
embryonic brain
embryonic ganglion mother cell
germ band | germline clone
germ band | nutrition conditional
larval central nervous system | embryonic stage
larval ventral nerve cord | embryonic stage
neuroblast | embryonic stage
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\FTH1
3 of 14
Yes
No
Hsap\FTHL17
3 of 14
Yes
No
Hsap\FTL
3 of 14
Yes
No
2  
Hsap\FTMT
3 of 14
Yes
No
Hsap\FTH1P19
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (20)
Rnor\Fth1
3 of 14
Yes
No
Rnor\Fthl17e
3 of 14
Yes
No
Rnor\Ftl1
3 of 14
Yes
No
Rnor\Ftmt
3 of 14
Yes
No
Rnor\LOC680520
3 of 14
Yes
No
Rnor\LOC100360087
3 of 14
Yes
No
Rnor\RGD1561661
3 of 14
Yes
No
Rnor\Fthl17c
2 of 14
No
No
Rnor\Ftl1l1
2 of 14
No
No
Rnor\LOC691895
2 of 14
No
No
Rnor\LOC100359668
2 of 14
No
No
Rnor\LOC100362384
2 of 14
No
No
Rnor\LOC108352322
2 of 14
No
No
Rnor\RGD1560203
2 of 14
No
No
Rnor\RGD1560687
2 of 14
No
No
Rnor\RGD1563378
2 of 14
No
No
Rnor\RGD1566189
2 of 14
No
No
Rnor\Ripor2
2 of 14
No
No
Rnor\LOC102549852
1 of 14
No
No
Rnor\RGD1561106
1 of 14
No
Yes
Mus musculus (laboratory mouse) (12)
Mmus\Ftdc1
3 of 14
Yes
No
Mmus\Ftdc2
3 of 14
Yes
Yes
Mmus\Fth1
3 of 14
Yes
No
Mmus\Fthl17a
3 of 14
Yes
No
Mmus\Fthl17b
3 of 14
Yes
No
Mmus\Fthl17c
3 of 14
Yes
No
Mmus\Fthl17d
3 of 14
Yes
No
Mmus\Fthl17e
3 of 14
Yes
No
Mmus\Fthl17f
3 of 14
Yes
No
Mmus\Ftl1
3 of 14
Yes
No
Mmus\Ftmt
3 of 14
Yes
No
Mmus\Ftl2-ps
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\ftmt
2 of 13
Yes
No
Xtro\arhgap40
1 of 13
No
No
Xtro\MGC75752
1 of 13
No
No
Xtro\MGC79725
1 of 13
No
No
Xtro\tomm20
1 of 13
No
No
Xtro\vma21
1 of 13
No
No
Danio rerio (Zebrafish) (11)
Drer\fth1a
3 of 14
Yes
No
Drer\fth1b
3 of 14
Yes
No
Drer\fthl28
3 of 14
Yes
No
Drer\fthl30
3 of 14
Yes
No
Drer\fthl31
3 of 14
Yes
No
Drer\zgc:56095
3 of 14
Yes
No
Drer\zgc:172145
3 of 14
Yes
No
Drer\fthl27
2 of 14
No
No
Drer\LOC100006428
2 of 14
No
No
Drer\fthl29
1 of 14
No
No
Drer\LOC558816
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\ftn-1
3 of 14
Yes
No
Cele\ftn-2
3 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP002464
10 of 12
Yes
Yes
Agam\AgaP_AGAP002465
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (5)
Atha\FER1
3 of 13
Yes
No
Atha\FER2
3 of 13
Yes
No
Atha\FER3
3 of 13
Yes
No
Atha\FER4
3 of 13
Yes
No
Atha\AT3G61010
2 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (2)
Ecol\ftnA
3 of 11
Yes
No
Ecol\ftnB
2 of 11
No
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Fer2LCH. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (2)
Fer1HCH
3 of 13
Fer3HCH
3 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 2 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FTH1; ferritin heavy chain 1
    3 of 14
    134770
    FTHL17; ferritin heavy chain like 17
    3 of 14
    300308
        FTL; ferritin light chain
        3 of 14
        134790
         
        FTMT; ferritin mitochondrial
        3 of 14
        608847
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Fer2LCH - Adh
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Aldo
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Argk1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - CG10581
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - CG14207
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - CG16826
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - CG31343
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - CG32473
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - CG34205
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - CG4390
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - CG5500
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - CG5506
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - CG7203
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Cpr62Bc
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Cpr64Ac
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Cs1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Fer1HCH
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Gpdh1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Lsp2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Mhc
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Mlc1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Mlc2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Nplp2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Obp44a
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Obp56d
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - PPO1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - PPO2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Prm
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Scp1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Tm2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Tsf1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Vajk2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Yp1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Yp2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - Yp3
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - apolpp
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - p24-1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Fer2LCH - step
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Liu et al., 2015)
            Fer2LCH - up
            experimental knowledge based
            (Guruharsha et al., 2011)
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Fer2LCH
            enhanceable
            Fer1HCH
            (Kosmidis et al., 2011)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Chi
            suppressible
            Fer2LCH
            (Bronstein et al., 2010)
            Fer1HCH
            enhanceable
            Fer2LCH
            (Kosmidis et al., 2014, Kosmidis et al., 2011)
            fh
            suppressible
            Fer1HCH|Fer2LCH
            (Chen et al., 2016, Navarro et al., 2015)
            Kr
            enhanceable
            Fer2LCH
            (Carrera et al., 1998)
            Ssdp
            enhanceable
            Fer2LCH
            (Bronstein et al., 2010)
            External Data
            Subunit Structure (UniProtKB)
            Oligomer of 12 light (L) chains and 12 heavy (H) chains; L and H chains are disulfide-linked (PubMed:9266686). The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble ferric iron core is deposited (PubMed:23771129).
            (UniProt, Q9VA83 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-100
            Cytogenetic map
            99F2-99F2
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            99F2-99F2
            Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            99F1-99F1
            (Dunkov, 1999.4.22, Dunkov, 1999.4.22)
            99F1-99F2
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            99F1-99F2
            (Dunkov and Law, 1999.3.20)
            97F-97F
            (determined by in situ hybridisation)
            (Gonzalez-Reyes, 1995.8.1)
            65A5-65A6
            70A1--2 71B4--5 73A9--10 91F1--5 97E1--F11 99A1--11 99F1--4
            (BDGP Project Members, 1994-1999)
            99F-99F
            (determined by in situ hybridisation)
            (Berg and Spradling, 1991)
            99F-99F
            (determined by in situ hybridisation) 97E--F (determined by in situ hybridisation)
            (Cooley et al., 1988)
            S. Wasserman's group have refined the mapping of the P-element in Fer2LCHneo60.
            (Gonzalez-Reyes, 1995.8.1)
            Experimentally Determined Recombination Data
            Location

            3-100

            (FlyBase, 2016)

            3-98.3

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (30)
            Genomic Clones (11)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (91)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Ma et al., 2024, Tang and Zhou, 2013, Missirlis et al., 2006)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                Encodes the 28kD ferritin subunit.

                (Georgieva et al., 1995)
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: Fer2LCH l(3)00035

                (Spradling et al., 1999)

                Source for merge of: Fer2LCH l(3)neo60 l(3)neo63

                (Beaton, 1999.12.12)

                Source for merge of: Fer2LCH CG1469

                (Bayraktaroglu, 2000.4.12)

                Source for merge of: Fer2LCH anon- EST:ParkEST264

                (Bayraktaroglu, 2000.11.2)
                Additional comments
                Nomenclature History
                Source for database identify of
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (32)
                Reported As
                Symbol Synonym
                2LCH
                (Georgieva et al., 2002)
                CG1469
                (Çiçek et al., 2016, Rosa-Ferreira et al., 2015, Shanshan and Laixin, 2015, Laslo et al., 2013, Tang and Zhou, 2013, Mandilaras and Missirlis, 2012, Cammarato et al., 2011, Bronstein et al., 2010, Ni et al., 2010.12.1, Shibata et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Reumer et al., 2009, Rival et al., 2009, Puri et al., 2008, Molnar et al., 2006, Karlsson et al., 2004, Levy et al., 2004, Vierstraete et al., 2003)
                Fe2LCH
                (Lye et al., 2014)
                Fer-H
                Fer2
                (Chen et al., 2016)
                Fer2LC
                (Rival et al., 2009)
                Fer2LCH
                (Kong et al., 2025, Rommelaere et al., 2025, Soltani et al., 2025, Huang et al., 2024, Ma et al., 2024, Meyer et al., 2024, Vesala et al., 2024, Dutta et al., 2023, Pang et al., 2021, Yu et al., 2021, Hernandez-Gallardo and Missirlis, 2020, Jeon et al., 2020, Rust et al., 2020, Vásquez-Procopio et al., 2020, Zhao and Zhou, 2020, Meltzer et al., 2019, Xiao et al., 2019, Calap-Quintana et al., 2018, Monnier et al., 2018, Calap-Quintana et al., 2017, Yoon et al., 2017, Chen et al., 2016, Clandinin and Owens, 2016-, Hosamani et al., 2016, Rosas-Arellano et al., 2016, González-Morales et al., 2015, Liu et al., 2015, Navarro et al., 2015, Spratford and Kumar, 2015, Zwarts et al., 2015, DeSalvo et al., 2014, Kosmidis et al., 2014, Zhu et al., 2014, Gutiérrez et al., 2013, Laslo et al., 2013, Mandilaras et al., 2013, Tang and Zhou, 2013, Tang and Zhou, 2013, Japanese National Institute of Genetics, 2012.5.21, Mandilaras and Missirlis, 2012, Kosmidis et al., 2011, Rees et al., 2011, Arancio et al., 2010, Bronstein et al., 2010, Li, 2010, Metzendorf and Lind, 2010, Tiklova et al., 2010, Gruenewald et al., 2009, Metzendorf et al., 2009, Reumer et al., 2009, Tan et al., 2009, Christensen et al., 2008.4.15, FlyBase Curators, 2008-, Puri et al., 2008, Buszczak et al., 2007, Missirlis et al., 2007, Dunkov and Georgieva, 2006, Missirlis et al., 2006, Molnar et al., 2006, Yepiskoposyan et al., 2006, Levy et al., 2004)
                FerLCH
                (Titlow et al., 2023, Ott et al., 2015, Liu et al., 2011)
                LCH
                (Kosmidis et al., 2004)
                anon-EST:ParkEST264
                fer2
                (Tiklová et al., 2010)
                fer2lch
                (Mendes et al., 2009)
                l(3)00035
                (Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)
                l(3)07016
                (Carrera et al., 1998)
                l(3)j2A3
                l(3)neo60
                (Gonzalez-Reyes, 1995.8.1, BDGP Project Members, 1994-1999, Cooley et al., 1988)
                l(3)neo63
                (BDGP Project Members, 1994-1999, Berg and Spradling, 1991, Cooley et al., 1988)
                l(3)s2083
                Name Synonyms
                Ferritin
                (Lind and Soderhall, 1998)
                Ferritin 2 Light Chain Homologue
                (Mandilaras and Missirlis, 2012)
                Ferritin 2 light chain
                (Shibata et al., 2010)
                Ferritin 2 light chain homolog
                (Zeng et al., 2015)
                Ferritin 2 light chain homologue
                (Cammarato et al., 2011, Li, 2010, Reumer et al., 2009, Xun et al., 2008)
                Ferritin L
                (Mandilaras and Missirlis, 2012)
                Ferritin-Heavy
                Ferritin-Light
                (Georgieva et al., 1995)
                Ferritin2
                (Chen et al., 2022)
                ferritin
                (Sadraie and Missirlis, 2011)
                ferritin 2 light chain
                (Rival et al., 2009)
                ferritin LCH
                (Kremer et al., 2009)
                ferritin light chain
                (Liu et al., 2011)
                ferritin-2 light chain homolog
                (Zhu et al., 2014)
                Secondary FlyBase IDs
                • FBgn0010705
                • FBgn0011018
                • FBgn0011321
                • FBgn0011490
                • FBgn0011491
                • FBgn0026287
                • FBgn0039763
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 84 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (147)