FerHCH, ferritin, ferritin heavy chain, l(3)00451, Fer1
iron storage proteins; ferroxidase and iron core nucleation- combines three functions: iron storage, intercellular iron transport, and protection from iron-induced oxidative stress
Please see the JBrowse view of Dmel\Fer1HCH for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.55
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
Gene model reviewed during 6.61
The group(s) of polypeptides indicated below share identical sequence to each other.
Oligomer of 12 light (L) chains and 12 heavy (H) chains; L and H chains are disulfide-linked (PubMed:23771129, PubMed:9266686). The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble ferric iron core is deposited (PubMed:23771129).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fer1HCH using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Fer1HCH is enriched about two-fold in the gut and Malpighian tubules.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Fer1HCH in JBrowse
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Iron availability alters the distribution of different Fer1HCH RNA alternative splice variants.
Conserved ferritin PCR primers are used to isolate a cDNA clone that contains the complete coding sequence for a ferritin subunit. Additional 5' sequence obtained by RACE method reveals the presence of a putative iron regulatory element. The deduced amino acid sequence contains a signal sequence that closely resembles the sequence from A.aegypti ferritin.
Encodes the 25kD and 26kD ferritin subunits.
Source for merge of: Fer1HCH l(3)00451 l(3)j10B4
Source for merge of: Fer1HCH BEST:LD36673
