FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Swip-1
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General Information
Symbol
Dmel\Swip-1
Species
D. melanogaster
Name
Swiprosin-1
Annotation Symbol
CG10641
Feature Type
protein_coding_gene
FlyBase ID
FBgn0032731
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
Swiprosin-1 (Swip-1) encodes a calcium binding protein, expressed in fusion competent myoblasts and macrophages of the embryo. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
37B8-37B8
Sequence location
Recombination map
2-54
RefSeq locus
NT_033779 REGION:18977519..18987280
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables actin filament binding
inferred from direct assay
(Lehne et al., 2022)
enables calcium ion sensor activity
inferred from direct assay
(Lehne et al., 2022)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables actin filament binding
traceable author statement
(Lehne and Bogdan, 2023)
enables calcium ion binding
inferred from electronic annotation with InterPro:IPR002048, InterPro:IPR040365
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000989515
(GO Reference Genome Project, 2011-)
enables calcium ion sensor activity
inferred from sequence or structural similarity with UniProtKB:Q9BUP0
(Gene Ontology Curators, 2002-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in actin crosslink formation
inferred from direct assay
(Lehne et al., 2022)
involved_in mesoderm development
inferred from expression pattern
(Furlong et al., 2001)
acts_upstream_of puparial adhesion
inferred from mutant phenotype
(Lehne and Bogdan, 2023)
involved_in regulated exocytosis
inferred from mutant phenotype
(Lehne and Bogdan, 2023)
involved_in wound healing
inferred from mutant phenotype
(Lehne et al., 2022)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
is_active_in lamellipodium
inferred from direct assay
(Lehne et al., 2022)
located_in plasma membrane
inferred from direct assay
(Hornbruch-Freitag et al., 2011)
is_active_in secretory granule membrane
inferred from direct assay
(Lehne and Bogdan, 2023)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Swiprosin-1 (Swip-1) encodes a calcium binding protein, expressed in fusion competent myoblasts and macrophages of the embryo. [Date last reviewed: 2019-03-14]
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Swip-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VJ26)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Swip-1-RA
FBtr0081185
NM_136081
1628
217
Swip-1-RB
FBtr0340322
NM_001299150
1860
217
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Swip-1-PA
FBpp0080727
25.1
217
4.77
Q9VJ26
NP_609925
AAF53731
Swip-1-PB
FBpp0309283
25.1
217
4.77
Q9VJ26
NP_001286079
AHN54593
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

217 aa isoforms: Swip-1-PA, Swip-1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Swip-1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.19

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 7 -- 11
trunk mesoderm
(Hornbruch-Freitag et al., 2011)
embryonic stage 9 -- 10
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
embryonic stage 12
somatic trunk mesoderm
(Hornbruch-Freitag et al., 2011)
visceral trunk mesoderm
(Hornbruch-Freitag et al., 2011)
embryonic stage 13 -- 15
larval somatic muscle cell
(Hornbruch-Freitag et al., 2011)
embryonic stage 13 -- 16
dorsal pharyngeal muscle cell
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
larval somatic muscle cell
(Fisher et al., 2012)
larval visceral muscle cell
(Fisher et al., 2012)
embryonic stage 15 -- 16
larval visceral muscle cell
(Hornbruch-Freitag et al., 2011)
embryonic/larval pharynx
(Hornbruch-Freitag et al., 2011)
Additional Descriptive Data

Swip-1 transcripts are present in the invaginating mesoderm from embryonic stage 7. During germband retraction they are present in the somatic and visceral mesoderm. During myoblast fusion-relevant stages, transcripts are observed in the somatic mesoderm but not the visceral myoblasts. In later stages they are observed in the visceral muscle and the pharynx.

(Hornbruch-Freitag et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
visceral trunk mesoderm
(Hornbruch-Freitag et al., 2011)
embryonic stage 11 -- 12
trunk mesoderm
(Hornbruch-Freitag et al., 2011)
somatic trunk mesoderm
(Hornbruch-Freitag et al., 2011)
embryonic stage 12
embryonic/larval head mesoderm derived hemocyte
(Hornbruch-Freitag et al., 2011)
embryonic stage 13 -- 15
fusion competent cell
(Hornbruch-Freitag et al., 2011)
embryonic stage 13 -- 16
larval somatic muscle cell

Comment: foci

(Hornbruch-Freitag et al., 2011)
muscle attachment site of embryonic/larval pharynx
(Hornbruch-Freitag et al., 2011)
muscle attachment site
(Hornbruch-Freitag et al., 2011)
embryonic stage 13 -- 17
larval central nervous system
(Hornbruch-Freitag et al., 2011)
embryonic stage 16
embryonic/larval hemocyte
(Hornbruch-Freitag et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- pupal stage
organism
(Hornbruch-Freitag et al., 2011)
Additional Descriptive Data

Swip-1 is detected in somatic and visceral mesoderm during germband extension. At later stages, it is detected in many foci in the somatic mesoderm. Swip-1 is detected at the contact sites of individual muscles in the pharynx and is observed in the CNS from stage 13 on. At stage 16, Swip-1 protein accumulates at the ends of muscles towards their epidermal attachment sites. Swip-1 protein is also observed in hemocytes in the head region and in macrophage-like hemocytes. Swip-1 protein is observed in embryos, larvae and pupae on western blots.

(Hornbruch-Freitag et al., 2011)
Marker for
 
embryonic/larval plasmatocyte
(Rudolf et al., 2012)
Subcellular Localization
CV Term
Evidence
References
is_active_in lamellipodium
inferred from direct assay
(Lehne et al., 2022)
located_in plasma membrane
inferred from direct assay
(Hornbruch-Freitag et al., 2011)
is_active_in secretory granule membrane
inferred from direct assay
(Lehne and Bogdan, 2023)
Expression Deduced from Reporters
Reporter: PBac{806.LOX-SVS-2}Swip-1CPTI004094
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
ellipsoid body | faint | restricted
(Knowles-Barley, 2011.8.24)
fan-shaped body layer | subset

Comment: fan-shaped body, higher in top layer

(Knowles-Barley, 2011.8.24)
adult mushroom body
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Swip-1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Swip-1
Transgenic constructs containing regulatory region of Swip-1
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2L)Exel6042
(Ryder, 2004.4.26)
Df(2L)Exel7073
(Ryder, 2004.4.26)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (25)
Hsap\EFHD2
14 of 14
Yes
Yes
Hsap\EFHD1
13 of 14
No
Yes
Hsap\AIF1
1 of 14
No
Yes
Hsap\AIF1L
1 of 14
No
Yes
Hsap\CABP1
1 of 14
No
No
Hsap\CABP2
1 of 14
No
No
Hsap\CABP5
1 of 14
No
No
Hsap\CALM1
1 of 14
No
No
Hsap\CALM2
1 of 14
No
No
1  
Hsap\CALM3
1 of 14
No
No
1  
Hsap\CALML3
1 of 14
No
No
Hsap\CALML5
1 of 14
No
No
Hsap\CALML6
1 of 14
No
No
Hsap\CETN1
1 of 14
No
No
Hsap\CETN2
1 of 14
No
No
Hsap\GPD2
1 of 14
No
No
Hsap\GUCA1A
1 of 14
No
No
Hsap\LOC118142757
1 of 14
No
No
Hsap\MYL5
1 of 14
No
No
Hsap\MYL9
1 of 14
No
No
1  
Hsap\MYL12A
1 of 14
No
No
1  
Hsap\MYL12B
1 of 14
No
No
1  
Hsap\PLS1
1 of 14
No
No
Hsap\PLS3
1 of 14
No
No
1  
Hsap\TNNC2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (18)
Rnor\Efhd2
14 of 14
Yes
Yes
Rnor\Efhd1
13 of 14
No
Yes
Rnor\Aif1l
1 of 14
No
Yes
Rnor\Aif1
1 of 14
No
Yes
Rnor\Cabp1
1 of 14
No
Yes
Rnor\Cabp2
1 of 14
No
No
Rnor\Calm1
1 of 14
No
No
Rnor\Calm2
1 of 14
No
No
Rnor\Calm3
1 of 14
No
No
Rnor\Calml3
1 of 14
No
No
Rnor\Cetn1
1 of 14
No
No
Rnor\Cetn2
1 of 14
No
No
Rnor\Dgkb
1 of 14
No
No
Rnor\Myl9
1 of 14
No
No
Rnor\Myl12a
1 of 14
No
No
Rnor\Myl12b
1 of 14
No
No
Rnor\Pls3
1 of 14
No
No
Rnor\Tnnc2
1 of 14
No
No
Mus musculus (laboratory mouse) (21)
Mmus\Efhd2
14 of 14
Yes
Yes
Mmus\Efhd1
12 of 14
No
Yes
Mmus\Aif1l
1 of 14
No
Yes
Mmus\Aif1
1 of 14
No
Yes
Mmus\Cabp1
1 of 14
No
No
Mmus\Cabp2
1 of 14
No
No
Mmus\Calm1
1 of 14
No
No
Mmus\Calm2
1 of 14
No
No
Mmus\Calm3
1 of 14
No
No
Mmus\Calm4
1 of 14
No
No
Mmus\Calm5
1 of 14
No
No
Mmus\Calml3
1 of 14
No
No
Mmus\Cetn1
1 of 14
No
No
Mmus\Cetn2
1 of 14
No
No
Mmus\Cetn4
1 of 14
No
No
Mmus\Dgkb
1 of 14
No
No
Mmus\Efcab3
1 of 14
No
Yes
Mmus\Myl9
1 of 14
No
No
Mmus\Myl12b
1 of 14
No
No
Mmus\Pls3
1 of 14
No
No
Mmus\Tnnc2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\efhd2
11 of 13
Yes
Yes
Xtro\efhd1
9 of 13
No
Yes
Xtro\cacna1h
1 of 13
No
No
Xtro\cetn1
1 of 13
No
No
Xtro\myl9
1 of 13
No
No
Xtro\myl12b
1 of 13
No
No
Xtro\pls1
1 of 13
No
No
Xtro\rbm42
1 of 13
No
No
Xtro\tnfsf10l
1 of 13
No
No
Xtro\tnnc1
1 of 13
No
No
Xtro\tnnc2
1 of 13
No
No
Danio rerio (Zebrafish) (22)
Drer\efhd2
14 of 14
Yes
Yes
Drer\efhd1
13 of 14
No
Yes
Drer\aif1l
1 of 14
No
Yes
Drer\cabp1a
1 of 14
No
No
Drer\cabp2a
1 of 14
No
No
Drer\cabp2b
1 of 14
No
No
Drer\cabp5b
1 of 14
No
No
Drer\calm1a
1 of 14
No
No
Drer\calm1b
1 of 14
No
No
Drer\calm2a
1 of 14
No
No
Drer\calm2b
1 of 14
No
No
Drer\calm3a
1 of 14
No
No
Drer\calm3b
1 of 14
No
No
Drer\caln1
1 of 14
No
Yes
Drer\cetn2
1 of 14
No
No
Drer\cetn4
1 of 14
No
No
Drer\guca1e
1 of 14
No
No
Drer\myl9b
1 of 14
No
No
Drer\myl12.2
1 of 14
No
No
Drer\pdcd6
1 of 14
No
No
Drer\si:ch211-103a14.5
1 of 14
No
No
Drer\tnnc2.1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (13)
Cele\efhd-1
9 of 14
Yes
Yes
Cele\B0563.7
1 of 14
No
No
Cele\cal-1
1 of 14
No
No
Cele\cal-2
1 of 14
No
No
Cele\cal-4
1 of 14
No
No
Cele\cal-5
1 of 14
No
No
Cele\cal-8
1 of 14
No
No
Cele\cmd-1
1 of 14
No
No
Cele\E02A10.3
1 of 14
No
No
Cele\K03A1.4
1 of 14
No
No
Cele\mlc-1
1 of 14
No
No
Cele\mlc-4
1 of 14
No
No
Cele\tnc-2
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (8)
Agam\AgaP_AGAP009528
12 of 12
Yes
Yes
Agam\AgaP_AGAP001622
1 of 12
No
No
Agam\AgaP_AGAP002536
1 of 12
No
No
Agam\AgaP_AGAP006508
1 of 12
No
No
Agam\AgaP_AGAP006622
1 of 12
No
No
Agam\AgaP_AGAP009260
1 of 12
No
No
Agam\AgaP_AGAP009330
1 of 12
No
No
Agam\AgaP_AGAP010957
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (33)
Atha\AT1G05990
1 of 13
Yes
Yes
Atha\AT1G18210
1 of 13
Yes
No
Atha\AT1G18530
1 of 13
Yes
No
Atha\AT1G24620
1 of 13
Yes
No
Atha\AT1G32250
1 of 13
Yes
No
Atha\AT1G76640
1 of 13
Yes
No
Atha\AT2G41090
1 of 13
Yes
No
Atha\AT3G03000
1 of 13
Yes
No
Atha\AT3G03430
1 of 13
Yes
Yes
Atha\AT3G25600
1 of 13
Yes
No
Atha\AT3G59440
1 of 13
Yes
Yes
Atha\CAM1
1 of 13
Yes
No
Atha\CAM2
1 of 13
Yes
No
Atha\CAM3
1 of 13
Yes
No
Atha\CAM4
1 of 13
Yes
No
Atha\CAM5
1 of 13
Yes
No
Atha\CAM6
1 of 13
Yes
No
Atha\CAM7
1 of 13
Yes
No
Atha\CAM8
1 of 13
Yes
No
Atha\CDPK6
1 of 13
Yes
No
Atha\CEN2
1 of 13
Yes
No
Atha\CEN2
1 of 13
Yes
No
Atha\CML11
1 of 13
Yes
No
Atha\CML23
1 of 13
Yes
No
Atha\CML30
1 of 13
Yes
Yes
Atha\CML42
1 of 13
Yes
No
Atha\CPK2
1 of 13
Yes
No
Atha\CPK5
1 of 13
Yes
No
Atha\CPK6
1 of 13
Yes
No
Atha\CPK26
1 of 13
Yes
No
Atha\MSS3
1 of 13
Yes
Yes
Atha\TCH2
1 of 13
Yes
No
Atha\TCH3
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CMD1
1 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\cam1
1 of 12
Yes
No
Spom\SPCC830.06
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Swip-1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (14)
CG14861
5 of 13
Acam
1 of 13
azot
1 of 13
Cam
1 of 13
CG11638
1 of 13
CG17493
1 of 13
CG30378
1 of 13
CG31802
1 of 13
Dgk
1 of 13
Eip63F-1
1 of 13
TpnC4
1 of 13
TpnC41C
1 of 13
TpnC47D
1 of 13
TpnC73F
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    EFHD2; EF-hand domain family member D2
    14 of 14
    616450
        EFHD1; EF-hand domain family member D1
        13 of 14
        611617
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            Swip-1 - Act57B
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Arp2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Arp3
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Arpc1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Arpc2
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Arpc3A
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Arpc4
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Arpc5
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - CG12177
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - CG7049
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - CG8578
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Cam
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Elp4
            anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
            (Rhee et al., 2014)
            Swip-1 - Gmppb
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Myo61F
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Plod
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Rae1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Rh5
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Shawn
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - Tm1
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - cpa
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - cpb
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - dachs
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Kwon et al., 2013)
            Swip-1 - didum
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - tmod
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - zip
            experimental knowledge based
            (Guruharsha et al., 2011)
            Swip-1 - ιTry
            experimental knowledge based
            (Guruharsha et al., 2011)
            Summary of Genetic Interactions
            Interaction Browsers
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-54
            Cytogenetic map
            37B8-37B8
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            37B8-37B8
            Limits computationally determined from genome sequence between P{EP}CG10413EP2164 and P{lacW}l(2)37Dbk16106&P{lacW}Catsupk05424
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location

            2-54

            (FlyBase, 2016)

            2-53.6

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (12)
            Genomic Clones (22)
            cDNA Clones (61)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Lehne and Bogdan, 2023, Lehne et al., 2022, Hornbruch-Freitag et al., 2011)
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments
                Relationship to Other Genes
                Source for database merge of
                Additional comments
                Nomenclature History
                Source for database identify of

                Source for identity of: Swip-1 CG10641

                (Hornbruch-Freitag et al., 2011)
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (10)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 48 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (63)