FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\RhoGAP71E
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General Information
Symbol
Dmel\RhoGAP71E
Species
D. melanogaster
Name
Rho GTPase activating protein at 71E
Annotation Symbol
CG32149
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036518
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Summary
Rho GTPase activating protein at 71E (RhoGAP71E) encodes a Rho GTPase activating protein that is involved in the regulation of actin dynamics during epithelial morphogenesis. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)
All Summaries
Also Known As

C-GAP, l(3)j6B9, Cumberland-GAP

Key Links
Genomic Location
Cytogenetic map
71E1-71E2
Sequence location
Recombination map
3-43
RefSeq locus
NT_037436 REGION:15588860..15609125
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables GTPase activator activity
inferred from mutant phenotype
(Mason et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables GTPase activator activity
inferred from sequence or structural similarity with SGD:S000000957
(Gene Ontology Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000571769
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in apical constriction involved in gastrulation
inferred from mutant phenotype
(Mason et al., 2016)
involved_in imaginal disc-derived leg morphogenesis
inferred from mutant phenotype
(Greenberg and Hatini, 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in Rho protein signal transduction
inferred from sequence or structural similarity with SGD:S000000957
(Gene Ontology Curators, 2002-)
involved_in signal transduction
inferred from electronic annotation with InterPro:IPR000198
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Mason et al., 2016)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Rho GTPase activating protein at 71E (RhoGAP71E) encodes a Rho GTPase activating protein that is involved in the regulation of actin dynamics during epithelial morphogenesis. [Date last reviewed: 2019-08-01]
Gene Group (FlyBase)
RHO GTPASE ACTIVATING PROTEINS -
RhoGAPs are GTPase activating proteins for Rho family GTPases. (Adapted from PMID:15731001 and FBrf0158741).
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
7

Please see the JBrowse view of Dmel\RhoGAP71E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry B7Z058)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.45

Alternative translation stop created by use of multiphasic reading frames within coding region.

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
RhoGAP71E-RA
FBtr0075568
NM_140527
3071
606
RhoGAP71E-RB
FBtr0075567
NM_168630
2922
604
RhoGAP71E-RC
FBtr0075569
NM_168629
5379
896
RhoGAP71E-RD
FBtr0290065
NM_001144484
5854
906
RhoGAP71E-RE
FBtr0303510
NM_001202183
4934
598
RhoGAP71E-RF
FBtr0332092
NM_001274957
4498
301
RhoGAP71E-RG
FBtr0332093
NM_001274958
4053
454
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
RhoGAP71E-PA
FBpp0075321
66.4
606
8.39
Q9VUR5
NP_648784
AAF49610
RhoGAP71E-PB
FBpp0075320
66.4
604
8.51
Q8IQM3
NP_730061
AAN11778
RhoGAP71E-PC
FBpp0075322
98.5
896
8.71
Q9VUR6
NP_730060
AAF49609
RhoGAP71E-PD
FBpp0288504
100.9
906
7.09
B7Z058
NP_001137956
ACL83311
RhoGAP71E-PE
FBpp0292544
65.4
598
8.39
M9MRW2
NP_001189112
ADV37548
RhoGAP71E-PF
FBpp0304402
34.1
301
9.95
M9PFR0
NP_001261886
AGB94579
RhoGAP71E-PG
FBpp0304403
49.9
454
10.14
M9PFL1
NP_001261887
AGB94580
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RhoGAP71E using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.37

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 6
cephalic furrow
(Mason et al., 2016)
ventral furrow
(Mason et al., 2016)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
larval lateral VNC glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
prepupal stage P3
leg joint of tarsal segment
(Greenberg and Hatini, 2011)
Additional Descriptive Data

RhoGAP71E trancripts are maternally deposited and enriched in the cephalic and ventral furrows during gastrulation.

(Mason et al., 2016)

Expression in stage P3 pupal leg discs is restricted to presumptive tarsal joints.

(Greenberg and Hatini, 2011)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Mason et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RhoGAP71E in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of RhoGAP71E
Transgenic constructs containing regulatory region of RhoGAP71E
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3L)st-f13
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Inferred from location ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (32)
Hsap\ARHGAP20
5 of 14
Yes
Yes
Hsap\TAGAP
4 of 14
No
Yes
Hsap\ARAP1
1 of 14
No
No
Hsap\ARHGAP1
1 of 14
No
No
1  
Hsap\ARHGAP5
1 of 14
No
No
Hsap\ARHGAP8
1 of 14
No
No
Hsap\ARHGAP11A
1 of 14
No
No
1  
Hsap\ARHGAP12
1 of 14
No
No
Hsap\ARHGAP15
1 of 14
No
No
Hsap\ARHGAP18
1 of 14
No
No
Hsap\ARHGAP21
1 of 14
No
No
Hsap\ARHGAP23
1 of 14
No
No
Hsap\ARHGAP24
1 of 14
No
No
1  
Hsap\ARHGAP26
1 of 14
No
No
Hsap\ARHGAP27
1 of 14
No
No
Hsap\ARHGAP28
1 of 14
No
No
Hsap\ARHGAP29
1 of 14
No
No
Hsap\ARHGAP33
1 of 14
No
No
Hsap\ARHGAP35
1 of 14
No
No
Hsap\ARHGAP40
1 of 14
No
No
Hsap\CHN1
1 of 14
No
No
Hsap\DLC1
1 of 14
No
No
3  
Hsap\FAM13A
1 of 14
No
No
Hsap\GMIP
1 of 14
No
No
Hsap\MYO9A
1 of 14
No
No
Hsap\MYO9B
1 of 14
No
No
Hsap\RALBP1
1 of 14
No
No
Hsap\SH3BP1
1 of 14
No
No
Hsap\SRGAP1
1 of 14
No
No
Hsap\SRGAP3
1 of 14
No
No
Hsap\STARD8
1 of 14
No
No
2  
Hsap\STARD13
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (28)
Rnor\Arhgap20
4 of 14
Yes
Yes
Rnor\Tagap
4 of 14
Yes
Yes
Rnor\tGap1
4 of 14
Yes
Yes
Rnor\LOC365791
3 of 14
No
Yes
Rnor\RGD1306519
3 of 14
No
Yes
Rnor\RGD1563562
3 of 14
No
Yes
Rnor\Arap1
1 of 14
No
No
Rnor\Arhgap1
1 of 14
No
No
Rnor\Arhgap6
1 of 14
No
No
Rnor\Arhgap8
1 of 14
No
No
Rnor\Arhgap11a
1 of 14
No
No
Rnor\Arhgap12
1 of 14
No
No
Rnor\Arhgap15
1 of 14
No
No
Rnor\Arhgap17
1 of 14
No
No
Rnor\Arhgap21
1 of 14
No
No
Rnor\Arhgap23
1 of 14
No
No
Rnor\Arhgap27
1 of 14
No
No
Rnor\Arhgap28
1 of 14
No
No
Rnor\Arhgap33
1 of 14
No
No
Rnor\Arhgap35
1 of 14
No
No
Rnor\Arhgap40
1 of 14
No
No
Rnor\Chn1
1 of 14
No
No
Rnor\Dlc1
1 of 14
No
No
Rnor\Myo9a
1 of 14
No
No
Rnor\Myo9b
1 of 14
No
No
Rnor\Sh3bp1
1 of 14
No
No
Rnor\Srgap3
1 of 14
No
No
Rnor\Stard13
1 of 14
No
No
Mus musculus (laboratory mouse) (30)
Mmus\1700006A11Rik
5 of 14
Yes
Yes
Mmus\Arhgap20
5 of 14
Yes
Yes
Mmus\Gm1527
5 of 14
Yes
Yes
Mmus\Tagap
5 of 14
Yes
Yes
Mmus\Tagap1
3 of 14
No
Yes
Mmus\Arap1
1 of 14
No
No
Mmus\Arhgap1
1 of 14
No
No
Mmus\Arhgap4
1 of 14
No
No
Mmus\Arhgap8
1 of 14
No
No
Mmus\Arhgap11a
1 of 14
No
No
Mmus\Arhgap12
1 of 14
No
No
Mmus\Arhgap15
1 of 14
No
No
Mmus\Arhgap17
1 of 14
No
No
Mmus\Arhgap18
1 of 14
No
No
Mmus\Arhgap21
1 of 14
No
No
Mmus\Arhgap23
1 of 14
No
No
Mmus\Arhgap27
1 of 14
No
No
Mmus\Arhgap28
1 of 14
No
No
Mmus\Arhgap29
1 of 14
No
No
Mmus\Arhgap33
1 of 14
No
No
Mmus\Arhgap35
1 of 14
No
No
Mmus\Arhgap40
1 of 14
No
No
Mmus\Chn1
1 of 14
No
No
Mmus\Dlc1
1 of 14
No
No
Mmus\Gmip
1 of 14
No
No
Mmus\Myo9a
1 of 14
No
No
Mmus\Myo9b
1 of 14
No
No
Mmus\Sh3bp1
1 of 14
No
No
Mmus\Srgap3
1 of 14
No
No
Mmus\Stard13
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (21)
Xtro\arhgap20
3 of 13
Yes
No
Xtro\capn15
3 of 13
Yes
No
Xtro\LOC100486629
3 of 13
Yes
Yes
Xtro\tagap
3 of 13
Yes
Yes
Xtro\arhgap4
1 of 13
No
Yes
Xtro\arhgap11a.1
1 of 13
No
Yes
Xtro\arhgap18
1 of 13
No
No
Xtro\arhgap21
1 of 13
No
No
Xtro\arhgap26
1 of 13
No
No
Xtro\arhgap28
1 of 13
No
No
Xtro\arhgap29
1 of 13
No
No
Xtro\arhgap35
1 of 13
No
No
Xtro\arhgap40
1 of 13
No
No
Xtro\dlc1
1 of 13
No
No
Xtro\fam13b
1 of 13
No
No
Xtro\gjb2
1 of 13
No
Yes
Xtro\sh3bp1
1 of 13
No
No
Xtro\srgap1
1 of 13
No
Yes
Xtro\sys1
1 of 13
No
No
Xtro\upk3b
1 of 13
No
Yes
Xtro\XB5822256
1 of 13
No
Yes
Danio rerio (Zebrafish) (26)
Drer\arhgap20
4 of 14
Yes
Yes
Drer\tagapa
4 of 14
Yes
Yes
Drer\tagapb
3 of 14
No
Yes
Drer\arap1a
1 of 14
No
No
Drer\arhgap12a
1 of 14
No
No
Drer\arhgap12b
1 of 14
No
No
Drer\arhgap18
1 of 14
No
No
Drer\arhgap20b
1 of 14
No
Yes
Drer\arhgap21a
1 of 14
No
No
Drer\arhgap21b
1 of 14
No
No
Drer\arhgap23a
1 of 14
No
No
Drer\arhgap23b
1 of 14
No
No
Drer\arhgap35a
1 of 14
No
No
Drer\arhgap35b
1 of 14
No
No
Drer\chn1
1 of 14
No
No
Drer\chn2
1 of 14
No
No
Drer\fam13b
1 of 14
No
No
Drer\LOC100332329
1 of 14
No
Yes
Drer\myo9aa
1 of 14
No
No
Drer\myo9ab
1 of 14
No
No
Drer\myo9b
1 of 14
No
No
Drer\ralbp1
1 of 14
No
No
Drer\sh3bp1
1 of 14
No
No
Drer\si:dkey-219e20.2
1 of 14
No
Yes
Drer\stard13a
1 of 14
No
No
Drer\stard13b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\rga-9
11 of 14
Yes
Yes
Cele\rga-2
2 of 14
No
Yes
Cele\cyk-4
1 of 14
No
No
Cele\gei-1
1 of 14
No
No
Cele\hum-7
1 of 14
No
Yes
Cele\rga-1
1 of 14
No
No
Cele\rga-8
1 of 14
No
No
Cele\spv-1
1 of 14
No
No
Cele\tag-325
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (9)
Agam\AgaP_AGAP011111
8 of 12
Yes
Yes
Agam\AgaP_AGAP000126
1 of 12
No
No
Agam\AgaP_AGAP000865
1 of 12
No
No
Agam\AgaP_AGAP002415
1 of 12
No
No
Agam\AgaP_AGAP003026
1 of 12
No
No
Agam\AgaP_AGAP004000
1 of 12
No
No
Agam\AgaP_AGAP005279
1 of 12
No
No
Agam\AgaP_AGAP008833
1 of 12
No
No
Agam\AgaP_AGAP009730
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\rga1
1 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:RhoGAP71E. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
conu
1 of 13
cv-c
1 of 13
RhoGAP5A
1 of 13
RhoGAP16F
1 of 13
RhoGAP18B
1 of 13
RhoGAP68F
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    RhoGAP71Ej6B9
    ameliorates  Huntington's disease
    modeled by Hsap\HTT128Q.1-336.UAS
    (Al-Ramahi et al., 2018)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ARHGAP20; Rho GTPase activating protein 20
    5 of 14
    609568
        TAGAP; T cell activation RhoGTPase activating protein
        4 of 14
        609667
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Interaction Browsers
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            RhoGAP71E
            suppressible
            RhoGEF2
            (Rosa-Birriel et al., 2024)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map
            3-43
            Cytogenetic map
            71E1-71E2
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            71E1-71E2
            Limits computationally determined from genome sequence between P{EP}Tfb2EP572 and P{lacW}thj5C8&P{PZ}Mbs03802
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            71E1-71E2
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            71E1-71E2
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location

            3-43

            (FlyBase, 2016)

            3-37.3

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (18)
            Genomic Clones (28)
            cDNA Clones (177)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: CG7396 CG16980

                (Billuart et al., 2001)

                Source for merge of: RhoGAP71E BcDNA:LD07615

                (FlyBase, 1996-)
                Additional comments

                Annotations CG7396, CG16980 merged as CG32149 in release 3 of the genome annotation.

                (FlyBase Genome Annotators, 2002-2003)

                Source for merge of RhoGAP71E BcDNA:LD07615 was a shared cDNA ( date:030728 ).

                (FlyBase, 1996-)
                Nomenclature History
                Source for database identify of
                Nomenclature comments
                Etymology

                Named 'Cumberland GAP (C-GAP)' after the passage or gap in the Appalachian Mountains, because this gene is expressed in the embryonic furrows and because this name reflects the mutant phenotype of the ventral furrow.

                (Mason et al., 2016)
                Synonyms and Secondary IDs (15)
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 68 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                References (71)