FlyBase Gene Report: Dmel\Prx5

General Information

Symbol

Dmel\Prx5

Species

D. melanogaster

Name

Peroxiredoxin 5

Annotation Symbol

CG7217

Feature Type

protein_coding_gene

FlyBase ID

FBgn0038570

Gene Model Status

Current

Stock Availability

6 publicly available

Enzyme Name (EC)

thioredoxin-dependent peroxiredoxin (1.11.1.24)

Gene Summary

Peroxiredoxin 5 (Prx5) encodes an atypical member of the family of thiol-specific peroxidases that forms intramolecular disulfide bonds during the catalytic cycle. Its roles include antioxidant function, maintenance of cellular redox state, modulation of the immune-related signaling and protection against apoptosis. [Date last reviewed: 2018-11-15] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

dprx5, PRDX5

Key Links

Genomic Location

Cytogenetic map

90F4-90F4

Sequence location

3R:18,165,442..18,167,273 [-]

Recombination map

3-62

RefSeq locus

NT_033777 REGION:18165442..18167273

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables oxidoreductase activity

inferred from electronic annotation with InterPro:IPR013740

(InterPro Project Members, 2004-)

enables thioredoxin peroxidase activity

inferred from sequence or structural similarity with UniProtKB:P30044-2

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN001625584

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR037944

(InterPro Project Members, 2004-)

enables thioredoxin-dependent peroxiredoxin activity

inferred from sequence or structural similarity with UniProtKB:P99029

(Gene Ontology Curators, 2002-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in cell redox homeostasis

inferred from genetic interaction with FLYBASE:Prx3; FB:FBgn0038519

(Radyuk et al., 2010)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Radyuk et al., 2010)

involved_in hydrogen peroxide catabolic process

inferred from mutant phenotype

(Radyuk et al., 2010)

involved_in negative regulation of apoptotic process

inferred from mutant phenotype

(Radyuk et al., 2010)

inferred from genetic interaction with FLYBASE:Prx3; FB:FBgn0038519

(Radyuk et al., 2010)

involved_in negative regulation of innate immune response

inferred from mutant phenotype

(Radyuk et al., 2010)

involved_in response to oxidative stress

inferred from mutant phenotype

(Radyuk et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cell redox homeostasis

inferred from biological aspect of ancestor with PANTHER:PTN001625584

(GO Reference Genome Project, 2011-)

involved_in cellular response to oxidative stress

inferred from electronic annotation with InterPro:IPR037944

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN001625584

(GO Reference Genome Project, 2011-)

involved_in hydrogen peroxide catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN001625584

(GO Reference Genome Project, 2011-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Radyuk et al., 2009)

located_in mitochondrion

inferred from direct assay

(Radyuk et al., 2009)

located_in nucleus

inferred from direct assay

(Radyuk et al., 2009)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN001625584

(GO Reference Genome Project, 2011-)

is_active_in mitochondrial matrix

traceable author statement

(Radyuk et al., 2010)

is_active_in mitochondrion

inferred from biological aspect of ancestor with PANTHER:PTN000046537

(GO Reference Genome Project, 2011-)

is_active_in peroxisome

inferred from biological aspect of ancestor with PANTHER:PTN000046537

(GO Reference Genome Project, 2011-)

located_in peroxisome

inferred from sequence or structural similarity with UniProtKB:P30044

(Faust et al., 2012)

Gene Group (FlyBase)

PEROXIREDOXINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

thioredoxin peroxidase activity
RHEA 63528: thioredoxin-dependent peroxiredoxin activity

a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]- disulfide + H2O (1.11.1.24)

RHEA 62620:

Summaries

Gene Snapshot

Gene Group (FlyBase)

PEROXIREDOXINS -: Peroxiredoxins are a family of thiol-dependent antioxidant proteins that catalyze the reduction of hydrogen peroxide, peroxynitrite and a wide range of organic hydroperoxides (ROOH) to the corresponding alcohol (ROH) and water. These proteins function as peroxidases only when coupled to a sulfhydryl-reducing system such as thioredoxin or glutathione. Catalytic activity is dependent on the oxidation of a conserved cysteine residue at the active site. (Adapted from FBrf0139661, PMID:12517450.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Prx5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q960M4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Dicistronic transcript isoform(s) appear to be relatively rare, based on RNA-Seq and/or EST data.

Gene model reviewed during 5.47

Gene model reviewed during 5.54

Gene model reviewed during 6.61

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Prx5-RA

FBtr0100619

NM_142422

1449

190

Prx5-RB

FBtr0100620

NM_001032020

733

190

Prx5-RC

FBtr0482696

630

157

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Prx5-PA

FBpp0100079

19.9

190

8.95

FBpp0100080

19.9

190

8.95

FBpp0428616

16.3

157

6.51

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

190 aa isoforms: Prx5-PA, Prx5-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q960M4

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Prx5 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.27

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

hindgut anlage

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

dorsal pharyngeal muscle primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

longitudinal trunk visceral muscle primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

dorsal pharyngeal muscle cell

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic Malpighian tubule

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

gastric caecum

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

Comment: varying levels through development parallel ecdysone pulses

(Radyuk et al., 2009)

Additional Descriptive Data

Prx5 levels vary dramatically during development with the highest levels in embryos. Later, increases are seen in late third instar larvae, early pupariation, and late pupariation. The changes largely parallel pulses of ecdysone synthesis.

(Radyuk et al., 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Radyuk et al., 2009)

located_in mitochondrion

inferred from direct assay

(Radyuk et al., 2009)

located_in nucleus

inferred from direct assay

(Radyuk et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Prx5 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Prx5

View exonic expression by tissue for Dmel\Prx5

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038570

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3771951/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038570

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038570

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038570

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32920

Flygut - An atlas of the Drosophila adult midgut

FBgn0038570

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Prx5

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Prx5

Transgenic constructs containing regulatory region of Prx5

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)189

(Viquez et al., 2006)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during embryonic stage | parental effect

Prx5^EY02106

Other Phenotypes

Allele

abnormal immune response

Prx5^EY02106

abnormal immune response, with Prx5^EY02106, Scer\GAL4^Act.PU

Prx5^UAS.cRa

abnormal immune response, with Prx5^EY02106, Scer\GAL4^da.G32

Prx5^UAS.cRa

abnormal immune response, with Prx5^UAS.cRa, Scer\GAL4^Act.PU

Prx5^EY02106

abnormal immune response, with Prx5^UAS.cRa, Scer\GAL4^da.G32

Prx5^EY02106

abnormal stress response

Prx5^EY02106

chemical resistant, with Scer\GAL4^arm.PS

Prx5^UAS.cRa

chemical resistant, with Scer\GAL4^αTub84B.PL

Prx5^UAS.cRa

chemical sensitive

Prx5^EY02106

increased cell death

Prx5^EY02106

long lived, with Scer\GAL4^arm.PS

Prx5^UAS.cRa

long lived, with Scer\GAL4^αTub84B.PL

Prx5^UAS.cRa

short lived

Prx5^EY02106

some die during embryonic stage | parental effect

Prx5^EY02106

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\PRDX5

13 of 14

Yes

Hsap\PRDX3

1 of 14

Hsap\PRDX4

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Prdx5

13 of 14

Yes

Rnor\LOC100362981

1 of 14

Yes

Rnor\Prdx3

1 of 14

Mus musculus (laboratory mouse) (2)

Mmus\Prdx5

13 of 14

Yes

Mmus\Prdx3

1 of 14

Xenopus tropicalis (Western clawed frog) (2)

Xtro\prdx5

7 of 13

Yes

Xtro\prdx6

1 of 13

Danio rerio (Zebrafish) (4)

Drer\prdx5

12 of 14

Yes

Drer\prdx3

1 of 14

Drer\prdx4

1 of 14

Drer\prdx6

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\prdx-6

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP001325

11 of 12

Yes

Agam\TPX2

1 of 12

Arabidopsis thaliana (thale-cress) (6)

Atha\AT1G60740

12 of 13

Yes

Atha\TPX1

12 of 13

Yes

Atha\TPX2

12 of 13

Yes

Atha\AT3G52960

10 of 13

Yes

Atha\PRXIIF

6 of 13

Yes

Atha\AT1G65990

4 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\AHP1

11 of 13

Yes

Scer\DOT5

1 of 13

Yes

Scer\PRX1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPCC330.06c

12 of 12

Yes

Escherichia coli (enterobacterium) (2)

Ecol\ahpC

1 of 11

Yes

Ecol\bcp

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Prx5. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

Prx6a

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PRDX5; peroxiredoxin 5

13 of 14

606583

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Prx5 - Urm1

anti tag coimmunoprecipitation, western blot

(Khoshnood et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Prx5

enhanceable

Prx3

(Radyuk et al., 2010)

Prx5|Prx3

suppressible

Trxr1

(Radyuk et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Prx3

enhanceable

Prx5

(Radyuk et al., 2010)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0038570

MIST (protein-protein) - An integrated Molecular Interaction Database

3771951

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Peroxisome

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_dicistronic_mRNA

(Michalak et al., 2008, FlyBase Genome Annotators, 2002-2003)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-62

Cytogenetic map

90F4-90F4

Sequence location

3R:18,165,442..18,167,273 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

90F4-90F4

Limits computationally determined from genome sequence between P{EP}cpo^EP3679 and P{EP}Dlc90F^EP3634

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-62

(FlyBase, 2016)

3-61.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

43461

w^*; P{GSV1}Prx5^EP-M106 CG7215^EP-M106

64998

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05872}attP40

81396

y¹ sc^* v¹ sev²¹; P{SAM.dCas9.GS03940}attP40

15852

y¹ w^67c23; P{EPgy2}Prx5^EY02106 CG7215^EY02106

7217R-3

v110117

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (257)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD45324

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0038570

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0038570

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Radyuk et al., 2010)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-unspecified : Stable S2 cell lines containing Tag:V5- and Tag:polyHis-tagged Prx5 were generated.
(Radyuk et al., 2009)

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

The CG7215 and Prx5 genes form a dicistronic operon. Analysis suggests that while the upstream CG7215 gene can be expressed from both mono- and dicistronic mRNAs, the downstream Prx5 gene is likely to be translated predominantly from its monocistronic transcripts.

(Michalak et al., 2008)

FlyBase curator comment: Correspondence with author Orr revealed that 'dprx5' = 'CG7217'.

(Orr et al., 2008)

Dicistronic annotation CG32920 split out into separate annotations for each open reading frame, CG7215 and CG7217, in release 4.2 of the genome annotation.

(FlyBase Genome Annotators, 2005)

One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG7215 and Prx5.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Prx5 CG7217

(Michalak et al., 2008)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG 32920

(Viquez et al., 2006)

CG 7217

(Viquez et al., 2006)

CG32920

(Yoshigi et al., 2013, Toledano-Katchalski et al., 2007, Giot et al., 2003)

CG7217

(Murari et al., 2022, Baron et al., 2016, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Laslo et al., 2013, Faust et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Cammarato et al., 2011, Robinson et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Manh et al., 2005)

PRDX5

(Anderson-Baron and Simmonds, 2018, Baron et al., 2016)

Prx5

(Tsakiri et al., 2025, Nozawa et al., 2023, Ostalé et al., 2021, Pridie et al., 2020, Shaposhnikov et al., 2020, Klichko et al., 2019, Anderson-Baron and Simmonds, 2018, Stapper and Jahn, 2018, Transgenic RNAi Project members, 2017-, Khoshnood et al., 2016, Deivasigamani et al., 2014, Mukherjee et al., 2014, Wang et al., 2014, de Celis et al., 2013.9.11, Yoshigi et al., 2013, Faust et al., 2012, Boyd et al., 2011)

dPRDX5

(Murari et al., 2022)

dPrx5

(Bradshaw, 2019, Detienne et al., 2018, Odnokoz et al., 2017, Radyuk et al., 2010, Radyuk et al., 2010, Michalak et al., 2008)

dPrxV

(Ahn et al., 2012)

dprx5

(Odnokoz et al., 2023, Klichko et al., 2019, Radyuk et al., 2010, Radyuk et al., 2010, Radyuk et al., 2009, Orr et al., 2008)

prx5

(Monnier et al., 2012)

Name Synonyms

CG7217

Peroxiredoxin 5

(Anderson-Baron and Simmonds, 2018, Khoshnood et al., 2016, Radyuk et al., 2010)

Peroxiredoxin V

(Ahn et al., 2012)

peroxiredoxin 5

(Laslo et al., 2013, Radyuk et al., 2010, Radyuk et al., 2010, Michalak et al., 2008, Orr et al., 2008)

Secondary FlyBase IDs

FBgn0052920
FBtr0083620
FBpp0083040
FBtr0083621
FBpp0083041
FBtr0083622
FBpp0083042

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3771951

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q960M4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q960M4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q960M4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0038570

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3771951/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0038570

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0038570

FlyMine - An integrated database for Drosophila genomics

FBgn0038570

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7217

MARRVEL_MODEL - MARRVEL (model organism gene)

3771951

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0038570

DroID - A comprehensive database of gene and protein interactions.

FBgn0038570

DRSC - Results frm RNAi screens

FBgn0038570

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0038570

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0038570

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32920

Flygut - An atlas of the Drosophila adult midgut

FBgn0038570

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0038570

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007642

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Peroxisome

MIST (protein-protein) - An integrated Molecular Interaction Database

3771951

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (71)

The following external sites may use different assemblies or annotations than FlyBase.

2.27

Report Sections