FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Mpv17
Open Close
General Information
Symbol
Dmel\Mpv17
Species
D. melanogaster
Name
Mitochondrial inner membrane protein MPV17
Annotation Symbol
CG11077
Feature Type
protein_coding_gene
FlyBase ID
FBgn0039930
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (PubMed:37810222). Can translocate uridine, but not orotate, across a lipid membrane (PubMed:37810222). Involved in maintenance of mitochondrial ultrastructure (PubMed:37810222). May be involved in mitochondrial DNA (mtDNA) maintenance but does not appear to be directly involved in mitochondrial deoxynucleoside triphosphate (dNTP) pool homeostasis (PubMed:37810222). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (PubMed:36587049). (UniProt, Q9V492)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

dMpv17

Key Links
Genomic Location
Cytogenetic map
102F6-102F6
Sequence location
Recombination map
4-0
RefSeq locus
NC_004353 REGION:1028675..1029361
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables monoatomic ion channel activity
inferred from direct assay
(Corrà et al., 2023)
enables uridine transmembrane transporter activity
inferred from direct assay
(Corrà et al., 2023)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000137626
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:P39210
(Kodani et al., 2022)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
acts_upstream_of mitochondrion organization
inferred from mutant phenotype
(Kodani et al., 2022)
involved_in monoatomic ion transmembrane transport
inferred from direct assay
(Corrà et al., 2023)
involved_in uridine transmembrane transport
inferred from direct assay
(Corrà et al., 2023)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
is_active_in mitochondrial inner membrane
inferred from direct assay
(Corrà et al., 2023)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000745045
(GO Reference Genome Project, 2011-)
located_in membrane
inferred from electronic annotation with InterPro:IPR007248
(InterPro Project Members, 2004-)
located_in mitochondrial inner membrane
inferred from sequence or structural similarity with UniProtKB:P39210
(Kodani et al., 2022)
inferred from sequence or structural similarity with UniProtKB:P39210
(Gene Ontology Curators, 2002-)
is_active_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN000884390
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the peroxisomal membrane protein PXMP2/4 family. (Q9V492)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
MPV17/PMP22 PUTATIVE MITOCHONDRIAL CHANNEL FAMILY -
The Mpv17/PMP22 (Mitochondrial inner membrane protein MPV17/Peroxisomal membrane protein 22) is family of putative pore/channel-forming proteins. This family is not well-characterised, but members generally are thought to act a non-selective ion channels/pores with a slight preference for cations.(Adapted from PMID:11590176, PMID:25861990, FBrf0257754 and FBrf0255401.)
Protein Function (UniProtKB)
Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (PubMed:37810222). Can translocate uridine, but not orotate, across a lipid membrane (PubMed:37810222). Involved in maintenance of mitochondrial ultrastructure (PubMed:37810222). May be involved in mitochondrial DNA (mtDNA) maintenance but does not appear to be directly involved in mitochondrial deoxynucleoside triphosphate (dNTP) pool homeostasis (PubMed:37810222). May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (PubMed:36587049).
(UniProt, Q9V492)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Mpv17 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9V492)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Mpv17-RA
FBtr0089222
NM_143687
687
168
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Mpv17-PA
FBpp0088286
19.5
168
10.22
Q9V492
NP_651944
AAF59393
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Part of a larger complex that may be a homohexamer.

(UniProt, Q9V492)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mpv17 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.52

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval garland cell
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
is_active_in mitochondrial inner membrane
inferred from direct assay
(Corrà et al., 2023)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Mpv17 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Mpv17
Transgenic constructs containing regulatory region of Mpv17
Aberrations (Deficiencies and Duplications) ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (4)
Hsap\MPV17
12 of 14
Yes
Yes
1  
Hsap\MPV17L2
4 of 14
No
No
Hsap\PXMP2
4 of 14
No
No
Hsap\MPV17L
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Mpv17
12 of 14
Yes
Yes
Rnor\Mpv17l2
4 of 14
No
No
Rnor\Pxmp2
4 of 14
No
No
Rnor\Mpv17l
2 of 14
No
No
Mus musculus (laboratory mouse) (4)
Mmus\Mpv17
12 of 14
Yes
Yes
Mmus\Mpv17l2
4 of 14
No
No
Mmus\Pxmp2
3 of 14
No
No
Mmus\Mpv17l
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\LOC100497159
2 of 13
Yes
No
Xtro\mpv17l2
2 of 13
Yes
No
Xtro\mpv17
2 of 13
Yes
Yes
Xtro\42Sp50
1 of 13
No
No
Xtro\mpv17l
1 of 13
No
No
Xtro\pxmp2
1 of 13
No
No
Danio rerio (Zebrafish) (5)
Drer\mpv17
12 of 14
Yes
Yes
Drer\mpv17l2
4 of 14
No
No
Drer\pxmp2
4 of 14
No
No
Drer\mpv17l
1 of 14
No
No
Drer\si:ch211-120k19.1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\T18D3.9
13 of 14
Yes
Yes
Cele\ZK470.1
4 of 14
No
No
Cele\ZK470.14
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (9)
Agam\AgaP_AGAP001778
11 of 12
Yes
Yes
Agam\AgaP_AGAP001403
3 of 12
No
No
Agam\AgaP_AGAP006040
3 of 12
No
No
Agam\AgaP_AGAP010066
3 of 12
No
No
Agam\AgaP_AGAP012390
3 of 12
No
No
Agam\AgaP_AGAP012415
3 of 12
No
No
Agam\AgaP_AGAP012621
3 of 12
No
No
Agam\AgaP_AGAP012622
3 of 12
No
No
Agam\AgaP_AGAP004046
2 of 12
No
No
Arabidopsis thaliana (thale-cress) (11)
Atha\AT5G19750
9 of 13
Yes
Yes
Atha\AT2G14860
5 of 13
No
No
Atha\AT2G42770
5 of 13
No
Yes
Atha\AT3G24570
5 of 13
No
Yes
Atha\AT4G33905
5 of 13
No
No
Atha\AT5G43140
5 of 13
No
No
Atha\PMP22
5 of 13
No
No
Atha\AT1G52870
4 of 13
No
Yes
Atha\AT4G03410
4 of 13
No
No
Atha\AT4G14305
2 of 13
No
Yes
Atha\AT4G14301
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\SYM1
8 of 13
Yes
Yes
Scer\YOR292C
5 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC4G9.14
8 of 12
Yes
Yes
Spom\SPAC3G6.05
6 of 12
No
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Mpv17. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (9)
CG1662
6 of 13
CG32262
6 of 13
CG5906
5 of 13
CG7970
5 of 13
CG14777
5 of 13
CG14778
5 of 13
CG32263
5 of 13
plh
5 of 13
CG12355
3 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 3 )
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MPV17; mitochondrial inner membrane protein MPV17
12 of 14
MITOCHONDRIAL INNER MEMBRANE PROTEIN MPV17; MPV17
 
MPV17L2; MPV17 mitochondrial inner membrane protein like 2
4 of 14
616133
      PXMP2; peroxisomal membrane protein 2
      4 of 14
      617399
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Interaction Browsers
          Summary of Genetic Interactions
          Interaction Browsers
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Subunit Structure (UniProtKB)
          Part of a larger complex that may be a homohexamer.
          (UniProt, Q9V492 )
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Linkouts
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          4
          Recombination map
          4-0
          Cytogenetic map
          102F6-102F6
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          102F6-102F6
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          4-0

          (FlyBase, 2016)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (14)
          Genomic Clones (10)
           

          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

          cDNA Clones (39)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments
              Relationship to Other Genes
              Source for database merge of
              Additional comments
              Nomenclature History
              Source for database identify of

              Source for identity of: Mpv17 CG11077

              (Kodani et al., 2022)
              Nomenclature comments
              Etymology

              Named 'Mpv17' after the vertebrate ortholog.

              (Kodani et al., 2022)
              Synonyms and Secondary IDs (6)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 32 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              References (43)