FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Lerp
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General Information
Symbol
Dmel\Lerp
Species
D. melanogaster
Name
lysosomal enzyme receptor protein
Annotation Symbol
CG31072
Feature Type
protein_coding_gene
FlyBase ID
FBgn0051072
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
lysosomal enzyme receptor protein (Lerp) encodes a protein involved in lysosome function and autophagy. [Date last reviewed: 2018-11-15] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
97D2-97D3
Sequence location
Recombination map
3-92
RefSeq locus
NT_033777 REGION:26842462..26863130
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (14 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with FLYBASE:Gga; FB:FBgn0030141
(Dennes et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables D-mannose binding
inferred from electronic annotation with InterPro:IPR000479
(InterPro Project Members, 2004-)
enables insulin-like growth factor binding
inferred from biological aspect of ancestor with PANTHER:PTN000824900
(GO Reference Genome Project, 2011-)
enables signaling receptor activity
inferred from electronic annotation with InterPro:IPR000479
(InterPro Project Members, 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in lysosomal transport
inferred from direct assay
(Dennes et al., 2005)
involved_in positive regulation of autophagy
inferred from mutant phenotype
(Hasanagic et al., 2015)
involved_in post-Golgi vesicle-mediated transport
inferred from direct assay
(Dennes et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in lysosomal transport
inferred from electronic annotation with InterPro:IPR000479
(InterPro Project Members, 2004-)
involved_in protein targeting to lysosome
inferred from biological aspect of ancestor with PANTHER:PTN000824899
(GO Reference Genome Project, 2011-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in clathrin-coated vesicle
inferred from direct assay
(Hirst et al., 2009)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Kametaka et al., 2010)
located_in trans-Golgi network
inferred from direct assay
(Kametaka et al., 2010)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred by curator from GO:0007041
(Dennes et al., 2005)
is_active_in late endosome
inferred from biological aspect of ancestor with PANTHER:PTN000386468
(GO Reference Genome Project, 2011-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000824900
(GO Reference Genome Project, 2011-)
is_active_in trans-Golgi network
inferred from biological aspect of ancestor with PANTHER:PTN004467936
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
lysosomal enzyme receptor protein (Lerp) encodes a protein involved in lysosome function and autophagy. [Date last reviewed: 2018-11-15]
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Lerp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4KH68)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Lerp-RA
FBtr0085099
NM_170289
3478
886
Lerp-RB
FBtr0085097
NM_170288
3457
887
Lerp-RD
FBtr0300939
NM_170290
3571
917
Lerp-RE
FBtr0334310
NM_001276067
3535
918
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Lerp-PA
FBpp0099603
97.2
886
6.26
Q8IMR0
NP_733168
AAN14088
Lerp-PB
FBpp0084467
97.3
887
6.26
Q8IMR1
NP_733167
AAN14087
Lerp-PD
FBpp0290161
100.0
917
6.35
B7Z0Q8
NP_733169
AAN14089
Lerp-PE
FBpp0306425
100.1
918
6.35
A0A0B4KH68
NP_001262996
AGB96376
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lerp using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.42

Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in clathrin-coated vesicle
inferred from direct assay
(Hirst et al., 2009)
located_in perinuclear region of cytoplasm
inferred from direct assay
(Kametaka et al., 2010)
located_in trans-Golgi network
inferred from direct assay
(Kametaka et al., 2010)
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.1}LerpMI09611-TG4.1
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted
(Lee et al., 2018)
neuron | subset of adult pars intercerebralis
(Lee et al., 2018)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Lerp in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Lerp
Transgenic constructs containing regulatory region of Lerp
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\IGF2R
9 of 14
Yes
Yes
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Igf2r
9 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Igf2r
9 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\igf2r
5 of 13
Yes
Yes
Xtro\palmd
1 of 13
No
Yes
Danio rerio (Zebrafish) (1)
Drer\igf2r
9 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP000998
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\MRL1
2 of 13
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC530.09c
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Lerp. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    IGF2R; insulin like growth factor 2 receptor
    model of  hepatocellular carcinoma
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    LerpGD306
    exacerbates  tauopathy
    modeled by Hsap\MAPTR406W.UAS
    (Butzlaff et al., 2015)
    LerpKK107813
    exacerbates  Alzheimer's disease
    modeled by PsnRNAi.UAS.3
    (Kang et al., 2024)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    IGF2R; insulin like growth factor 2 receptor
    9 of 14
    147280
     
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Lerp - Gga
    pull down, western blot
    (Dennes et al., 2005)
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    bchs
    enhanceable
    Lerp
    (Hasanagic et al., 2015)
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-92
    Cytogenetic map
    97D2-97D3
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    97D2-97D3
    Limits computationally determined from genome sequence between P{lacW}scribj7B3 and P{lacW}His2AvL1602
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-92

    (FlyBase, 2016)

    3-88.9

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (12)
    Genomic Clones (27)
    cDNA Clones (13)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Hasanagic et al., 2015, Kowalewski-Nimmerfall et al., 2014, Eissenberg et al., 2011)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            Area matching Drosophila EST AA247082. Probable intron in gene represented by EST AA247082.

            (Davies, 2001.3.15)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: Lerp anon-WO0118547.383

            (FlyBase, 1996-)

            Source for merge of: CG6390 CG6396 CG14256 CG14255

            (FlyBase Genome Annotators, 2002-2003)
            Additional comments

            One of the introns of Lerp has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the Lerp intron is mir-1012.

            (Ruby et al., 2007)

            Annotations CG6390, CG6396, CG14256 and CG14255 merged as CG31072 in release 3 of the genome annotation.

            (FlyBase Genome Annotators, 2002-2003)

            Source for merge of Lerp anon-WO0118547.383 was sequence comparison ( date:051113 ).

            (FlyBase, 1996-)
            Nomenclature History
            Source for database identify of
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (11)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 57 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            MIST (genetic) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (67)