FlyBase Gene Report: Dmel\Cubn

General Information

Symbol

Dmel\Cubn

Species

D. melanogaster

Name

Cubilin

Annotation Symbol

CG32702

Feature Type

protein_coding_gene

FlyBase ID

FBgn0052702

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Required in the nephrocyte for normal uptake of proteins and elimination of toxins, and for maintenance of endocytic trafficking structures. May function together with Amnionless. (UniProt, Q9W332)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

dCubilin

Key Links

Genomic Location

Cytogenetic map

8E7-8E10

Sequence location

X:9,558,665..9,571,308 [-]

Recombination map

1-28

RefSeq locus

NC_004354 REGION:9558665..9571308

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables cargo receptor activity

inferred from direct assay

(Atienza-Manuel et al., 2021)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097

(InterPro Project Members, 2004-)

enables cargo receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002344811

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in clathrin-dependent endocytosis

inferred from mutant phenotype

(Atienza-Manuel et al., 2021)

involved_in nephrocyte filtration

inferred from mutant phenotype

(Zhang et al., 2013)

involved_in renal protein absorption

inferred from mutant phenotype

(Atienza-Manuel et al., 2021, Zhang et al., 2013)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of receptor complex

inferred from physical interaction with FLYBASE:Amnionless; FB:FBgn0025686,FLYBASE:Cubn2; FB:FBgn0259140

(Atienza-Manuel et al., 2021)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

Required in the nephrocyte for normal uptake of proteins and elimination of toxins, and for maintenance of endocytic trafficking structures. May function together with Amnionless.

(UniProt, Q9W332)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cubn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W332)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cubn-RB

FBtr0273437

NM_167193

11349

3750

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cubn-PB

FBpp0271945

418.2

3750

5.32

Q9W332

NP_727348

AAF46505

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W332

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cubn using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cubn_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.35

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

larval pericardial cell

(Zhang et al., 2013)

larval stage

larval pericardial cell

(Zhang et al., 2013)

embryonic/larval garland cell

(Zhang et al., 2013)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

spermatozoon

(Wasbrough et al., 2010)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of receptor complex

inferred from physical interaction with FLYBASE:Amnionless; FB:FBgn0025686,FLYBASE:Cubn2; FB:FBgn0259140

(Atienza-Manuel et al., 2021)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cubn in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cubn

View exonic expression by tissue for Dmel\Cubn

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

326235/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052702

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052702

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052702

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32702

Flygut - An atlas of the Drosophila adult midgut

FBgn0052702

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cubn

Transgenic constructs containing regulatory region of Cubn

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 19 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Cubn^B2

viable, with Scer\GAL4^Mef2.PR

Cubn^GD6458

viable, with Scer\GAL4^pnr-MD237

Cubn^GD6458

viable, with Scer\GAL4^tin.CΔ4

Cubn^GD6458

viable, with Scer\GAL4^Ugt36A1.PK

Cubn^GD6458

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage, with Scer\GAL4^Ugt36A1.PK

chemical sensitive, with Scer\GAL4^Ugt36A1.PK

Cubn^GD6458

increased speed of aging, with Scer\GAL4^Ugt36A1.PK

short lived, with Scer\GAL4^Ugt36A1.PK

Phenotype manifest in

Allele

adult brain, with Scer\GAL4^Ugt36A1.PK

adult pericardial cell, with Scer\GAL4^Ugt36A1.PK

indirect flight muscle cell, with Scer\GAL4^Ugt36A1.PK

larval pericardial cell, with Scer\GAL4^Ugt36A1.PK

Cubn^GD6458

nephrocyte | larval stage

Cubn^B2

nephrocyte | larval stage, with Scer\GAL4^sns.PU

Cubn^JF03118

nephrocyte diaphragm | larval stage

Cubn^B2

nephrocyte diaphragm | larval stage, with Scer\GAL4^sns.PU

Cubn^JF03118

nucleus | larval stage

Cubn^B2

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (60)

Hsap\CUBN

12 of 14

Yes

Hsap\CDCP2

2 of 14

Yes

Hsap\MFRP

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DCBLD1

1 of 14

Yes

Hsap\DCBLD2

1 of 14

Yes

Hsap\DMBT1

1 of 14

Hsap\EDIL3

1 of 14

Hsap\EGFL6

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\JAG1

1 of 14

Hsap\KLRG1

1 of 14

Yes

Hsap\KREMEN2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\NRP2

1 of 14

Yes

Hsap\PCOLCE2

1 of 14

Hsap\PCOLCE

1 of 14

Yes

Hsap\PDGFC

1 of 14

Hsap\PDGFD

1 of 14

Hsap\PROS1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (36)

Rnor\Cubn

11 of 14

Yes

Rnor\Cdcp2

2 of 14

Yes

Rnor\Mfrp

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Dcbld2

1 of 14

Yes

Rnor\Dmbt1

1 of 14

Yes

Rnor\Edil3

1 of 14

Yes

Rnor\Egfl6

1 of 14

Yes

Rnor\Egfl7

1 of 14

Rnor\Egfl8

1 of 14

Rnor\F8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\LOC100911413

1 of 14

Rnor\Lrp12

1 of 14

Rnor\Masp2

1 of 14

Yes

Rnor\Megf6

1 of 14

Rnor\Mfge8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Nrp2

1 of 14

Yes

Rnor\Pcolce

1 of 14

Yes

Rnor\Pdgfc

1 of 14

Rnor\Pdgfd

1 of 14

Rnor\Pros1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (42)

Mmus\Cubn

11 of 14

Yes

Mmus\Cdcp2

2 of 14

Yes

Mmus\Cuzd1

2 of 14

Yes

Mmus\Dmbt1

2 of 14

Yes

Mmus\Mfrp

2 of 14

Yes

Mmus\Bmp1

1 of 14

Mmus\C1qtnf5

1 of 14

Yes

Mmus\Cd163

1 of 14

Yes

Mmus\Cdcp3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Edil3

1 of 14

Yes

Mmus\Egfem1

1 of 14

Mmus\Egfl6

1 of 14

Yes

Mmus\Egfl7

1 of 14

Mmus\Egfl8

1 of 14

Mmus\F5

1 of 14

Yes

Mmus\F8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Nrp2

1 of 14

Yes

Mmus\Pcolce

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (38)

Xtro\cubn

11 of 13

Yes

Xtro\cdcp2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\edil3

1 of 13

Xtro\efcab7

1 of 13

Yes

Xtro\egfl6

1 of 13

Yes

Xtro\fat1

1 of 13

Xtro\gprin3

1 of 13

Yes

Xtro\hmcn1

1 of 13

Xtro\jag1

1 of 13

Xtro\krt8.1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ovch2

1 of 13

Xtro\pamr1

1 of 13

Xtro\pcnp

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (54)

Drer\cubn

11 of 14

Yes

Drer\cdcp2

2 of 14

Yes

Drer\mfrp

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\csmd2

1 of 14

Drer\csmd3a

1 of 14

Drer\cuzd1.1

1 of 14

Yes

Drer\cuzd1.2

1 of 14

Drer\edil3a

1 of 14

Yes

Drer\edil3b

1 of 14

Yes

Drer\egfl6

1 of 14

Yes

Drer\egfl7

1 of 14

Drer\f5

1 of 14

Yes

Drer\f8

1 of 14

Yes

Drer\gas6

1 of 14

Yes

Drer\LOC560447

1 of 14

Drer\LOC101885457

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\mfge8b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\nrp2a

1 of 14

Yes

Drer\nrp2b

1 of 14

Yes

Drer\oit3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\pear1

1 of 14

Drer\pros1

1 of 14

Yes

Drer\si:ch211-194g2.4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (37)

Cele\cubn-1

12 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Cele\clec-3

1 of 14

Yes

Cele\clec-4

1 of 14

Cele\clec-5

1 of 14

Yes

Cele\clec-6

1 of 14

Yes

Cele\clec-7

1 of 14

Cele\clec-8

1 of 14

Yes

Cele\clec-9

1 of 14

Cele\clec-10

1 of 14

Yes

Cele\clec-11

1 of 14

Yes

Cele\clec-12

1 of 14

Yes

Cele\clec-13

1 of 14

Yes

Cele\clec-15

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\clec-55

1 of 14

Yes

Cele\clec-56

1 of 14

Yes

Cele\clec-57

1 of 14

Yes

Cele\clec-78

1 of 14

Cele\clec-227

1 of 14

Yes

Cele\clec-264

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\sol-1

1 of 14

Cele\W02G9.4

1 of 14

Yes

Cele\Y64G10A.7

1 of 14

Anopheles gambiae (African malaria mosquito) (15)

Agam\AgaP_AGAP005526

11 of 12

Yes

Agam\AgaP_AGAP001415

2 of 12

Agam\CTL5

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (5)

Atha\VSR3

1 of 13

Yes

Atha\VSR4

1 of 13

Yes

Atha\VSR5

1 of 13

Yes

Atha\VSR6

1 of 13

Yes

Atha\VSR7

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\RMD6

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cubn. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (27)

Cubn2

11 of 13

CG34370

2 of 13

CG42613

2 of 13

tld

2 of 13

tok

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

crb

1 of 13

Delta

1 of 13

mgl

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

uif

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

kidney disease (postulated), CUBN-related

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Cubn^GD6458

model of kidney disease

CEA

(Zhang et al., 2013)

Cubn^JF03118

model of kidney disease

CEA

(Xi et al., 2024)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CUBN; cubilin

model of megaloblastic anemia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CUBN; cubilin

12 of 14

602997

megaloblastic anemia

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Cubn - Amnionless

anti tag coimmunoprecipitation, anti tag western blot

(Atienza-Manuel et al., 2021)

Cubn - Cubn2

anti tag coimmunoprecipitation, anti tag western blot

(Atienza-Manuel et al., 2021)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cubn

suppressible

G6pd

(Xi et al., 2024)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0052702

MIST (protein-protein) - An integrated Molecular Interaction Database

326235

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-28

Cytogenetic map

8E7-8E10

Sequence location

X:9,558,665..9,571,308 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

8E7-8E10

Limits computationally determined from genome sequence between P{EP}EP1450&P{EP}EP1356 and P{EP}EP912^EP912

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-28

(FlyBase, 2016)

1-30.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

28702

y¹ v¹; P{TRiP.JF03118}attP2

51736

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03167}attP2

NIG-Fly

HMJ23087

y¹ v¹; P{TRiP.HMJ23087}attP40/CyO

HMS03167

y¹ sc^* v¹ sev²¹; P{TRiP.HMS03167}attP2/TM3, Sb¹

VDRC

v14613

w¹¹¹⁸; P{GD6458}v14613

v14614

w¹¹¹⁸; P{GD6458}v14614

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0052702

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0052702

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Annotation CG2996 split in release 3 of the genome annotation. Release 3 annotation CG32699 contains sequences corresponding to release 2 annotation CG15318 and parts of release 2 annotation CG2996. Release 3 annotation CG32702 contains sequences corresponding to parts of release 2 annotation CG2996.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Cubn CG32702

(Zhang et al., 2013)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG2996

(BDGP Project Members, 2000-)

CG32702

(National Institute of Genetics Fly Stocks, 2023-, Hosono et al., 2015, Zhang et al., 2013, Zhang et al., 2013, Zhang et al., 2013, Mandilaras and Missirlis, 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Wasbrough et al., 2010, Perkins et al., 2009, Prokupek et al., 2008, Tao et al., 2007)

CT7882

(Hynes and Zhao, 2000)

Cubn

(Spitz et al., 2025, Meyer et al., 2024, Huang et al., 2023, Lai and Vogan, 2023, van de Leemput et al., 2022, Atienza-Manuel et al., 2021, Fu et al., 2017, Hermle et al., 2017)

cubilin

(Selma-Soriano et al., 2020)

dCubn

(Zhang et al., 2013)

tok-like

(Hynes and Zhao, 2000)

Name Synonyms

Cubilin

(Jog et al., 2025, Koehler and Huber, 2023, Hermle et al., 2017, Zhang et al., 2013)

Cubilin ortholog

TMPRSS6 iron sensing

(Mandilaras and Missirlis, 2012)

dCubilin

(Feng et al., 2021, Zhang et al., 2013)

Secondary FlyBase IDs

FBgn0030138

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

326235

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W332

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W332

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W332

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

326235/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0052702

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0052702

FlyMine - An integrated database for Drosophila genomics

FBgn0052702

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG32702

MARRVEL_MODEL - MARRVEL (model organism gene)

326235

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0052702

DroID - A comprehensive database of gene and protein interactions.

FBgn0052702

DRSC - Results frm RNAi screens

FBgn0052702

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cubn_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0052702

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0052702

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG32702

Flygut - An atlas of the Drosophila adult midgut

FBgn0052702

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

MIST (protein-protein) - An integrated Molecular Interaction Database

326235

References (48)

The following external sites may use different assemblies or annotations than FlyBase.

-1.35

Report Sections