FlyBase Gene Report: Dmel\Rbp

General Information

Symbol

Dmel\Rbp

Species

D. melanogaster

Name

RIM-binding protein

Annotation Symbol

CG43073

Feature Type

protein_coding_gene

FlyBase ID

FBgn0262483

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Summary

RIM-binding protein (Rbp) encodes an active zone protein involved in neuromuscular synaptic transmission and presynaptic active zone organization. [Date last reviewed: 2019-09-19] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

DRBP, rim-bp, RimBP

Key Links

Genomic Location

Cytogenetic map

88F3-88F4

Sequence location

3R:15,374,635..15,402,543 [+]

Recombination map

3-57

RefSeq locus

NT_033777 REGION:15374635..15402543

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in cytoskeletal matrix organization at active zone

inferred from mutant phenotype

(Liu et al., 2011)

involved_in neuromuscular synaptic transmission

inferred from mutant phenotype

(Liu et al., 2011)

involved_in presynaptic active zone organization

inferred from genetic interaction with FLYBASE:brp; FB:FBgn0259246

(Böhme et al., 2016)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in neuromuscular synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN002306629

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytoskeleton of presynaptic active zone

inferred from direct assay

(Liu et al., 2011)

is_active_in neuromuscular junction

inferred from direct assay

(Liu et al., 2011)

is_active_in presynaptic active zone cytoplasmic component

inferred from direct assay

(Liu et al., 2011)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

RIM-binding protein (Rbp) encodes an active zone protein involved in neuromuscular synaptic transmission and presynaptic active zone organization. [Date last reviewed: 2019-09-19]

Summary (Interactive Fly)

presynaptic scaffolding protein - neuromuscular junction - essential for the integrity of the synaptic active zone scaffold and for exocytotic neurotransmitter release

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Rbp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4JDC9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.46

Alternative translation stop created by use of multiphasic reading frames within coding region.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 6.05

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Rbp-RF

FBtr0304826

NM_001202298

8410

1844

Rbp-RG

FBtr0304827

NM_001202297

5797

1817

Rbp-RI

FBtr0333832

NM_001275672

6581

1799

Rbp-RJ

FBtr0333833

NM_001275673

6118

1763

Rbp-RK

FBtr0433493

NM_169652

8251

1748

Rbp-RL

FBtr0433494

NM_169654

6405

1487

Rbp-RM

FBtr0433495

NM_001316579

8302

1765

Rbp-RN

FBtr0433496

NM_001170149

5848

1791

Rbp-RO

FBtr0433497

NM_169653

5654

1473

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Rbp-PF

FBpp0293366

194.0

1844

6.74

FBpp0293367

191.4

1817

6.74

FBpp0305966

189.0

1799

6.47

FBpp0305967

185.2

1763

6.45

FBpp0390599

183.6

1748

6.38

FBpp0390600

156.1

1487

6.12

FBpp0390601

185.1

1765

6.33

FBpp0390602

188.0

1791

6.43

FBpp0390603

154.9

1473

6.15

Q86BS0

NP_732029

AAF55194

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rbp using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.69

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

embryonic/larval neuromuscular junction

• presynaptic active zone

(Liu et al., 2011)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoskeleton of presynaptic active zone

inferred from direct assay

(Liu et al., 2011)

is_active_in neuromuscular junction

inferred from direct assay

(Liu et al., 2011)

is_active_in presynaptic active zone cytoplasmic component

inferred from direct assay

(Liu et al., 2011)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Rbp in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Rbp

View exonic expression by tissue for Dmel\Rbp

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262483

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41880/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262483

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262483

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 23 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Rbp

Transgenic constructs containing regulatory region of Rbp

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel6174

(Ryder, 2004.4.26)

Df(3R)S201

(Liu et al., 2011)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(3R)Exel6174)

Rbp^{MI06739-TG4.0}

lethal (with Df(3R)S201)

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Rbp^GD5161

partially lethal - majority die (with Df(3R)S201)

Rbp^MB02027

viable, with Scer\GAL4^Mef2.PR

Rbp^GD17369

viable, with Scer\GAL4^pnr-MD237

Rbp^GD17369

Other Phenotypes

Allele

abnormal locomotor behavior | larval stage

abnormal locomotor behavior | larval stage (with Df(3R)S201)

Rbp^MB02027

abnormal neurophysiology

Rbp^MB02027

abnormal neurophysiology | larval stage

some die during pupal stage, with Scer\GAL4^pnr-MD237

Rbp^GD5161

visible, with Scer\GAL4^Bx-MS1096

Rbp^UAS.Tag:HA

Phenotype manifest in

Allele

cytoskeleton of presynaptic active zone

Rbp^STOP1

cytoskeleton of presynaptic active zone (with Df(3R)S201)

Rbp^MB02027

embryonic/larval neuromuscular junction | larval stage

synaptic vesicle

Rbp^STOP1

wing, with Scer\GAL4^Bx-MS1096

Rbp^UAS.Tag:HA

wing vein | ectopic, with Scer\GAL4^Bx-MS1096

Rbp^UAS.Tag:HA

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (20)

Hsap\RIMBP2

12 of 14

Yes

Hsap\TSPOAP1

9 of 14

Yes

Hsap\RIMBP3B

4 of 14

Yes

Hsap\RIMBP3C

4 of 14

Yes

Hsap\RIMBP3

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (16)

Rnor\Rimbp2

11 of 14

Yes

Rnor\Tspoap1

9 of 14

Yes

Rnor\Rimbp3

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (16)

Mmus\Rimbp2

11 of 14

Yes

Mmus\Tspoap1

9 of 14

Yes

Mmus\Rimbp3

4 of 14

Yes

Mmus\Cd2ap

1 of 14

Mmus\Dnmbp

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (10)

Xtro\rimbp2

6 of 13

Yes

Xtro\tspoap1

5 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (20)

Drer\rimbp2a

11 of 14

Yes

Drer\rimbp2b

10 of 14

Yes

Drer\si:ch211-105f12.2

7 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\rimb-1

11 of 14

Yes

Cele\itsn-1

1 of 14

Cele\nck-1

1 of 14

Cele\pqn-63

1 of 14

Yes

Cele\T04C9.1

1 of 14

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP003735

6 of 12

Yes

Agam\AgaP_AGAP013187

2 of 12

Yes

Agam\AgaP_AGAP004211

1 of 12

Agam\AgaP_AGAP007717

1 of 12

Agam\AgaP_AGAP009037

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPBC119.05c

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Rbp. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

Dap160

1 of 13

dock

1 of 13

nwk

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

TSPOAP1; TSPO associated protein 1

model of dystonia 22, adult-onset

IEA

(FlyBase, 2019-)

model of dystonia 22, juvenile-onset

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Rbp^MB02027

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Bernstein et al., 2016)

modeled by Hsap\MAPT^V337M.UAS

(Bernstein et al., 2016)

modeled by Hsap\MAPT^R406W.UAS

(Bernstein et al., 2016)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RIMBP2; RIMS binding protein 2

12 of 14

611602

TSPOAP1; TSPO associated protein 1

9 of 14

610764

RIMBP3B; RIMS binding protein 3B

4 of 14

612700

RIMBP3C; RIMS binding protein 3C

4 of 14

612701

RIMBP3; RIMS binding protein 3

4 of 14

612699

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Rbp - Aplip1

two hybrid, x-ray crystallography, isothermal titration calorimetry, predetermined participant

(Petzoldt et al., 2020, Siebert et al., 2015)

Rbp - Fife

two hybrid

(Petzoldt et al., 2020)

Rbp - Rim

isothermal titration calorimetry, predetermined participant, two hybrid

(Petzoldt et al., 2020, Siebert et al., 2015, Liu et al., 2011)

Rbp - brp

two hybrid, anti bait coimmunoprecipitation, western blot, protein cross-linking with a bifunctional reagent, Identification by mass spectrometry

(Petzoldt et al., 2020)

Rbp - cac

two hybrid, isothermal titration calorimetry, predetermined participant, x-ray crystallography

(Petzoldt et al., 2020, Siebert et al., 2015, Liu et al., 2011)

Rbp - unc-13

two hybrid

(Petzoldt et al., 2020, Böhme et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0262483

MIST (protein-protein) - An integrated Molecular Interaction Database

41880

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Pregnenolone biosynthesis

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012, Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-57

Cytogenetic map

88F3-88F4

Sequence location

3R:15,374,635..15,402,543 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

88F3-88F4

Limits computationally determined from genome sequence between P{lacW}MRG15^j6A3 and P{PZ}l(3)06536⁰⁶⁵³⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-57

(FlyBase, 2016)

3-56.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

29312

y¹ v¹; P{TRiP.JF02471}attP2

54828

y¹ v¹; P{TRiP.HMJ21547}attP40

32814

y¹ w^*; Mi{MIC}Rbp^MI02015

23409

w¹¹¹⁸; Mi{ET1}Rbp^MB02027/TM6C, Sb¹

32739

y¹ w^*; Mi{MIC}h-cup^MI01164 Rbp^MI01164

83489

y¹ sc^* v¹ sev²¹; P{TKO.GS04193}attP40

40746

y¹ w^*; Mi{MIC}Rbp^MI02820/TM3, Sb¹ Ser¹

67469

y¹ w^*; Mi{Trojan-GAL4.0}Rbp^{MI06739-TG4.0}/TM3, Sb¹ Ser¹

NIG-Fly

14867R-3

P{NIG.14867R}3

HMJ21547

y¹ v¹; P{TRiP.HMJ21547}attP40/CyO

VDRC

v49176

w¹¹¹⁸; P{GD17369}v49176

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (17)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0262483

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0262483

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Petzoldt et al., 2020, Böhme et al., 2016, Depner et al., 2014, Liu et al., 2011)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG5143 CG5152

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: CG31302 CG14867

(FlyBase Genome Annotators, 2010)

Additional comments

Annotations CG31302 and CG14867 merged as CG43073 in release 5.31 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Annotations CG5143 and CG5152 merged as CG31302 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Rbp CG43073

(Liu et al., 2011)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG14867

(Sun et al., 2017, Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21)

CG31302

(Smibert et al., 2012, Friedman et al., 2011, Perkins et al., 2009, Friedman and Perrimon, 2006)

CG43073

(Ugrankar et al., 2015, Rodriguez et al., 2012, Friedman et al., 2011, Liu et al., 2011, FlyBase Genome Annotators, 2010, Ni et al., 2010.12.1)

CG5143

(Boutros et al., 2004)

CG5152

DRBP

(Bai and Suzuki, 2020, Shearin et al., 2018, Sugie et al., 2018, Harris and Littleton, 2015, Sugie et al., 2015, Matkovic et al., 2013)

RBP

(Huang et al., 2020, Gupta et al., 2016, Siebert et al., 2015)

RIM-BP

(Turrel et al., 2022, Götz et al., 2021)

Rbp

(Crane et al., 2025, Cypranowska et al., 2025, Hofbauer et al., 2024, Corthals et al., 2023, Goel and Dickman, 2021, Michki et al., 2021, Xie et al., 2021, Yeates and Frank, 2021, Kurmangaliyev et al., 2020, Böhme et al., 2019, Lee et al., 2018, Ortega et al., 2018, Transgenic RNAi Project members, 2017-, Bernstein et al., 2016, Böhme et al., 2016, Gene Disruption Project members, 2016-, Liu et al., 2011)

RimBP

(Ghelani et al., 2023, Piao and Sigrist, 2021)

dRIM-BP

(Szikora et al., 2021)

drbp

(Liu et al., 2011)

rbp

(Wentzel et al., 2018, Muller et al., 2015)

rim-bp

(Chou et al., 2020, Petzoldt et al., 2020, Driller et al., 2019)

Name Synonyms

RIM-binding protein

(Muller et al., 2015)

Rab3-interacting molecule (RIM)-binding protein

(Liu et al., 2011)

Secondary FlyBase IDs

FBgn0051302
FBgn0038335
FBgn0038336
FBgn0038333

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 81 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41880

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

CZ490023

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4JDC9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4JDC9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0262483

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41880/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0262483

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0262483

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43073

MARRVEL_MODEL - MARRVEL (model organism gene)

41880

PDB - An information portal to biological macromolecular structures

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0262483

DroID - A comprehensive database of gene and protein interactions.

FBgn0262483

DRSC - Results frm RNAi screens

FBgn0262483

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0262483

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033471

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

41880

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Pregnenolone biosynthesis

References (85)

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