FlyBase Gene Report: Dmel\M7BP

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\M7BP using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.96

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

colocalizes_with actin cytoskeleton

inferred from direct assay

(Liu et al., 2021)

located_in cytosol

inferred from direct assay

(Liu et al., 2021)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\M7BP in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\M7BP

View exonic expression by tissue for Dmel\M7BP

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35698/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263077

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027604

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263077

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30494

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of M7BP

Transgenic constructs containing regulatory region of M7BP

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)Exel6053

(Ryder, 2004.4.26)

Df(2R)Exel7092

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

M7BP^GD5485

viable, with Scer\GAL4^Mef2.PR

M7BP^GD5485

viable, with Scer\GAL4^pnr-MD237

M7BP^GD5485

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (5)

Hsap\DMP1

1 of 14

Yes

Hsap\IBSP

1 of 14

Yes

Hsap\LEO1

1 of 14

Yes

Hsap\MUCL3

1 of 14

Yes

Hsap\RP1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Dmp1

1 of 14

Yes

Rnor\Ibsp

1 of 14

Yes

Rnor\Leo1

1 of 14

Yes

Rnor\Rp1

1 of 14

Yes

Mus musculus (laboratory mouse) (4)

Mmus\Dmp1

1 of 14

Yes

Mmus\Ibsp

1 of 14

Yes

Mmus\Leo1

1 of 14

Yes

Mmus\Rp1

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (2)

Drer\gpatch3

1 of 14

Yes

Drer\leo1

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\T24E12.10

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP005840

4 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP007562

1 of 12

Arabidopsis thaliana (thale-cress) (5)

Atha\AT3G05900

1 of 13

Yes

Atha\AT3G56410

1 of 13

Yes

Atha\AT5G40450

1 of 13

Yes

Atha\G2484-1

1 of 13

Yes

Atha\SYD

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\AIP5

1 of 13

Yes

Scer\CHS5

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\pic1

1 of 12

Yes

Spom\sec16

1 of 12

Yes

Spom\SPAC1A6.07

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:M7BP. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (10)

1 of 13

1 of 13

1 of 13

1 of 13

Dtg

1 of 13

Lmpt

1 of 13

Muc18B

1 of 13

Su(var)2-HP2

1 of 13

tnc

1 of 13

zormin

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

M7BP - egl

anti tag coimmunoprecipitation, quantitative reverse transcription pcr, full identification by DNA sequencing

(Vazquez-Pianzola et al., 2017)

protein-protein

Physical Interaction

Assay

References

M7BP - InR

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

M7BP - ck

pull down, western blot, bio-layer interferometry, two hybrid

(Liu et al., 2021)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263077

MIST (protein-protein) - An integrated Molecular Interaction Database

35698

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

(FlyBase Genome Annotators, 2011)

protein_coding_gene

(FlyBase Genome Annotators, 2011)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-57

Cytogenetic map

43E5-43E7

Sequence location

2R:7,623,242..7,651,787 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

43E5-43E7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-57

(FlyBase, 2016)

2-56.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

28423

y¹ w^*; P{EP}M7BP^G19466

32813

y¹ w^*; Mi{MIC}M7BP^MI02009

38086

y¹ w^*; Mi{MIC}M7BP^MI05034

59361

y¹ w^*; Mi{MIC}M7BP^MI13810

33349

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00217}attP2

41926

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02323}attP2

11695

2088R-1

HMS00217

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00217}attP2

HMS02323

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02323}attP2

VDRC

v104153

P{KK105457}VIE-260B

v108330

P{KK106651}VIE-260B

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (77)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI15208

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0263077

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Liu et al., 2021)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

(Claridge-Chang et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG30492 BcDNA:HL07907

(FlyBase, 1996-)

Additional comments

One of the alternative 5' leading exons of CG30492 has been split out into its own separate annotation (CG43341) in release 5.36 of the genome annotation. The remainder of CG30492 has been merged with CG30494 to produce CG43340 in release 5.36 of the genome annotation.

(FlyBase Genome Annotators, 2011)

Annotation CG2088 split into CG30492 and CG30494 ( BcDNA:GH02712 ) in release 3 of the genome annotation. In addition, release 3 annotation CG30492 contains sequences corresponding to release 2 annotations CG17984 and CG2080.

(FlyBase Genome Annotators, 2002-2003)

Comments: Source for merge of CG30492 BcDNA:HL07907 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: M7BP CG43340

(Liu et al., 2021)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

BcDNA:GH02712

(Giot et al., 2003)

BcDNA:HL07907

CG17983

CG17984

CG2080

(Stanyon et al., 2004)

CG2088

(Claridge-Chang et al., 2001)

CG30492

(Ashwal-Fluss et al., 2014, Carreira et al., 2011, Friedman et al., 2011, Kong et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Park and Song, 2008)

CG30494

(Chen et al., 2012, Zhang et al., 2010, Keleman et al., 2009.8.5, Wijnen et al., 2006)

CG43340

(Ko et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Liu et al., 2021, Vazquez-Pianzola et al., 2017, Kavi et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1)

CT6764

(Ceriani et al., 2002)

M7BP

(Liu et al., 2021)

Name Synonyms

Myosin-7a binding protein

myosin-7a binding protein

(Liu et al., 2021)

Secondary FlyBase IDs

FBgn0050492
FBan0030492
FBgn0263045
FBgn0027604
FBgn0050494
FBgn0033197
FBgn0033198
FBgn0040781
FBgn0063175

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 83 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35698

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4K7U0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4K7U0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35698/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263077

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263077

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43340

MARRVEL_MODEL - MARRVEL (model organism gene)

35698

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0263077

DroID - A comprehensive database of gene and protein interactions.

FBgn0263077

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027604

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0263077

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG30494

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014626

MIST (protein-protein) - An integrated Molecular Interaction Database

35698

References (45)

The following external sites may use different assemblies or annotations than FlyBase.

-0.96

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