FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Ntl
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General Information
Symbol
Dmel\Ntl
Species
D. melanogaster
Name
Neurotransmitter transporter-like
Annotation Symbol
CG7075
Feature Type
protein_coding_gene
FlyBase ID
FBgn0267326
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
Neurotransmitter transporter-like (Ntl) encodes a glycine transporter of the SLC6 class, closely related to neurotransmitter transporters and other amino acid transporters. Ntl expression is testes-specific and its mutants are male-sterile, producing sperm with a significant reduction in glycylated tubulin. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
28C1-28C1
Sequence location
Recombination map
2-28
RefSeq locus
NT_033779 REGION:7710880..7713991
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables glycine transmembrane transporter activity
inferred from mutant phenotype
(Chatterjee et al., 2011)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables amino acid:sodium symporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000907238
(GO Reference Genome Project, 2011-)
enables glycine transmembrane transporter activity
inferred from sequence or structural similarity with UniProtKB:Q9Y345
(Chatterjee et al., 2011)
enables L-proline transmembrane transporter activity
inferred from sequence model
(Thimgan et al., 2006)
enables neurotransmitter transmembrane transporter activity
inferred from sequence or structural similarity with FLYBASE:DAT; FB:FBgn0034136
(Romero-Calderon et al., 2007)
Biological Process (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in flagellated sperm motility
inferred from mutant phenotype
(Chatterjee et al., 2011)
involved_in glycine import across plasma membrane
inferred from mutant phenotype
(Chatterjee et al., 2011)
involved_in positive regulation of protein polyglycylation
inferred from mutant phenotype
(Chatterjee et al., 2011)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in glycine import across plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000907238
(GO Reference Genome Project, 2011-)
involved_in neurotransmitter transport
inferred from sequence or structural similarity with FLYBASE:DAT; FB:FBgn0034136
(Romero-Calderon et al., 2007)
involved_in proline transport
inferred from sequence model
(Thimgan et al., 2006)
involved_in sodium ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000177662
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in membrane
inferred from sequence model
(Thimgan et al., 2006)
inferred from electronic annotation with InterPro:IPR000175
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000177662
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Neurotransmitter transporter-like (Ntl) encodes a glycine transporter of the SLC6 class, closely related to neurotransmitter transporters and other amino acid transporters. Ntl expression is testes-specific and its mutants are male-sterile, producing sperm with a significant reduction in glycylated tubulin. [Date last reviewed: 2019-03-21]
Gene Group (FlyBase)
SLC6 FAMILY OF SODIUM/CHLORIDE-DEPENDENT NEUROTRANSMITTER TRANSPORTERS -
Solute carrier family 6 (SLC6) members are Na+/Cl--dependent transporters of extracellular neurotransmitters, amino acids and osmolytes across the plasma membrane into the cytosol. (Adapted from FBrf0193583).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Ntl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VLY6)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ntl-RA
FBtr0079478
NM_135291
2069
590
Ntl-RB
FBtr0079479
NM_164765
1860
542
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Ntl-PA
FBpp0079102
67.2
590
8.44
Q9VLY6
NP_609135
AAF52543
Ntl-PB
FBpp0079103
61.6
542
7.66
Q8IPH3
NP_723303
AAN10641
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ntl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.60

Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult thorax

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)
adult abdomen

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ntl in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ntl
Transgenic constructs containing regulatory region of Ntl
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 12 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (19)
Hsap\SLC6A9
7 of 14
Yes
Yes
Hsap\SLC6A7
6 of 14
No
Yes
Hsap\SLC6A5
5 of 14
No
No
1  
Hsap\SLC6A14
5 of 14
No
No
Hsap\SLC6A1
3 of 14
No
No
5  
Hsap\SLC6A2
3 of 14
No
No
Hsap\SLC6A3
3 of 14
No
No
24  
Hsap\SLC6A6
3 of 14
No
No
Hsap\SLC6A8
3 of 14
No
No
Hsap\SLC6A11
3 of 14
No
No
Hsap\SLC6A12
3 of 14
No
No
1  
Hsap\SLC6A13
3 of 14
No
No
Hsap\SLC6A15
3 of 14
No
No
Hsap\SLC6A16
3 of 14
No
Yes
Hsap\SLC6A17
3 of 14
No
No
Hsap\SLC6A4
2 of 14
No
No
3  
Hsap\SLC6A18
2 of 14
No
No
Hsap\SLC6A19
2 of 14
No
No
1  
Hsap\SLC6A20
2 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (20)
Rnor\Slc6a9
7 of 14
Yes
Yes
Rnor\Slc6a7
6 of 14
No
Yes
Rnor\Slc6a5
5 of 14
No
No
Rnor\Slc6a14
5 of 14
No
No
Rnor\Slc6a1
3 of 14
No
No
Rnor\Slc6a2
3 of 14
No
No
Rnor\Slc6a3
3 of 14
No
No
Rnor\Slc6a6
3 of 14
No
No
Rnor\Slc6a11
3 of 14
No
No
Rnor\Slc6a12
3 of 14
No
No
Rnor\Slc6a13
3 of 14
No
No
Rnor\RGD1562492
2 of 14
No
No
Rnor\Slc6a4
2 of 14
No
No
Rnor\Slc6a8
2 of 14
No
No
Rnor\Slc6a17
2 of 14
No
No
Rnor\Slc6a18
2 of 14
No
No
Rnor\Slc6a19
2 of 14
No
No
Rnor\Slc6a20
2 of 14
No
No
Rnor\Slc6a15
1 of 14
No
No
Rnor\Slc6a16
1 of 14
No
No
Mus musculus (laboratory mouse) (21)
Mmus\Slc6a9
7 of 14
Yes
Yes
Mmus\Slc6a7
6 of 14
No
Yes
Mmus\Slc6a14
5 of 14
No
Yes
Mmus\Slc6a5
4 of 14
No
No
Mmus\Slc6a1
3 of 14
No
No
Mmus\Slc6a2
3 of 14
No
No
Mmus\Slc6a3
3 of 14
No
No
Mmus\Slc6a4
3 of 14
No
No
Mmus\Slc6a6
3 of 14
No
No
Mmus\Slc6a8
3 of 14
No
No
Mmus\Slc6a11
3 of 14
No
No
Mmus\Slc6a12
3 of 14
No
No
Mmus\Slc6a13
3 of 14
No
No
Mmus\Slc6a15
2 of 14
No
No
Mmus\Slc6a16
2 of 14
No
Yes
Mmus\Slc6a18
2 of 14
No
No
Mmus\Slc6a19
2 of 14
No
No
Mmus\Slc6a20a
2 of 14
No
No
Mmus\Slc6a20b
2 of 14
No
No
Mmus\Slc6a17
1 of 14
No
No
Mmus\Slc6a21
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (26)
Xtro\slc6a9
6 of 13
Yes
Yes
Xtro\slc6a8
3 of 13
No
No
Xtro\slc6a14.2
3 of 13
No
Yes
Xtro\LOC100497766
2 of 13
No
No
Xtro\lyl1
2 of 13
No
No
Xtro\slc6a4l
2 of 13
No
No
Xtro\slc6a5
2 of 13
No
No
Xtro\slc6a6
2 of 13
No
No
Xtro\slc6a7
2 of 13
No
No
Xtro\slc6a8l
2 of 13
No
No
Xtro\slc6a15
2 of 13
No
No
Xtro\slc6a17
2 of 13
No
No
Xtro\cdc37
1 of 13
No
No
Xtro\cflar
1 of 13
No
Yes
Xtro\LOC100490052
1 of 13
No
Yes
Xtro\myog
1 of 13
No
No
Xtro\slc6a1
1 of 13
No
No
Xtro\slc6a2
1 of 13
No
No
Xtro\slc6a3
1 of 13
No
No
Xtro\slc6a4
1 of 13
No
No
Xtro\slc6a12
1 of 13
No
No
Xtro\slc6a13
1 of 13
No
No
Xtro\slc6a14.1
1 of 13
No
Yes
Xtro\tnip1
1 of 13
No
No
Xtro\XB5944457
1 of 13
No
No
Xtro\zmiz2
1 of 13
No
No
Danio rerio (Zebrafish) (35)
Drer\slc6a9
7 of 14
Yes
Yes
Drer\slc6a7
6 of 14
No
Yes
Drer\slc6a5
5 of 14
No
No
Drer\slc6a14
5 of 14
No
Yes
Drer\si:ch211-117c9.5
3 of 14
No
No
Drer\si:ch211-132b12.1
3 of 14
No
No
Drer\si:ch211-132b12.2
3 of 14
No
No
Drer\si:ch211-132b12.3
3 of 14
No
No
Drer\slc6a1b
3 of 14
No
No
Drer\slc6a1l
3 of 14
No
No
Drer\slc6a3
3 of 14
No
No
Drer\slc6a4a
3 of 14
No
No
Drer\slc6a4b
3 of 14
No
No
Drer\slc6a8
3 of 14
No
No
Drer\slc6a11a
3 of 14
No
No
Drer\slc6a13
3 of 14
No
No
Drer\slc6a22.1
3 of 14
No
No
Drer\slc6a22.2
3 of 14
No
No
Drer\zgc:158427
3 of 14
No
No
Drer\si:ch211-132b12.6
2 of 14
No
No
Drer\si:ch211-225b11.1
2 of 14
No
No
Drer\si:ch211-283g2.1
2 of 14
No
No
Drer\slc6a1a
2 of 14
No
No
Drer\slc6a2
2 of 14
No
No
Drer\slc6a6a
2 of 14
No
No
Drer\slc6a6b
2 of 14
No
No
Drer\slc6a11b
2 of 14
No
No
Drer\slc6a16a
2 of 14
No
No
Drer\slc6a19a.1
2 of 14
No
No
Drer\slc6a19a.2
2 of 14
No
No
Drer\slc6a19b
2 of 14
No
No
Drer\slc6a15
1 of 14
No
No
Drer\slc6a16b
1 of 14
No
No
Drer\slc6a17
1 of 14
No
No
Drer\slc6a18
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (15)
Cele\snf-2
4 of 14
Yes
No
Cele\snf-7
4 of 14
Yes
No
Cele\snf-9
4 of 14
Yes
No
Cele\dat-1
3 of 14
No
No
Cele\F56F4.3
3 of 14
No
Yes
Cele\mod-5
3 of 14
No
No
Cele\snf-3
3 of 14
No
No
Cele\snf-5
3 of 14
No
No
Cele\snf-6
3 of 14
No
Yes
Cele\snf-10
3 of 14
No
Yes
Cele\snf-11
3 of 14
No
No
Cele\snf-12
3 of 14
No
No
Cele\Y43D4A.1
3 of 14
No
Yes
Cele\snf-1
2 of 14
No
No
Cele\snf-8
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (22)
Agam\AgaP_AGAP008467
11 of 12
Yes
Yes
Agam\AgaP_AGAP010481
4 of 12
No
No
Agam\AgaP_AGAP010860
4 of 12
No
No
Agam\AgaP_AGAP010861
4 of 12
No
Yes
Agam\AgaP_AGAP007367
3 of 12
No
No
Agam\AgaP_AGAP009768
3 of 12
No
No
Agam\AgaP_AGAP010621
3 of 12
No
No
Agam\AgaP_AGAP010857
3 of 12
No
No
Agam\AgaP_AGAP010865
3 of 12
No
No
Agam\AgaP_AGAP000493
2 of 12
No
Yes
Agam\AgaP_AGAP000637
2 of 12
No
No
Agam\AgaP_AGAP004932
2 of 12
No
No
Agam\AgaP_AGAP008940
2 of 12
No
No
Agam\AgaP_AGAP010858
2 of 12
No
No
Agam\AgaP_AGAP010859
2 of 12
No
Yes
Agam\AgaP_AGAP011279
2 of 12
No
No
Agam\AgaP_AGAP012565
2 of 12
No
Yes
Agam\AgaP_AGAP012626
2 of 12
No
No
Agam\AgaP_AGAP000494
1 of 12
No
Yes
Agam\AgaP_AGAP001194
1 of 12
No
No
Agam\AgaP_AGAP010862
1 of 12
No
No
Agam\AgaP_AGAP012290
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Ntl. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (21)
CG1698
5 of 13
CG4476
5 of 13
CG8850
5 of 13
CG13796
5 of 13
CG15279
5 of 13
DAT
5 of 13
Gat
5 of 13
GlyT
5 of 13
ine
5 of 13
List
5 of 13
NAAT1
5 of 13
SerT
5 of 13
CG13793
4 of 13
CG13794
4 of 13
CG13795
4 of 13
CG31904
4 of 13
CG33296
4 of 13
CG43066
4 of 13
blot
3 of 13
CG10804
3 of 13
bdg
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC6A9; solute carrier family 6 member 9
    7 of 14
    601019
      SLC6A7; solute carrier family 6 member 7
      6 of 14
      606205
          SLC6A5; solute carrier family 6 member 5
          5 of 14
          604159
           
          SLC6A14; solute carrier family 6 member 14
          5 of 14
          300444
              SLC6A1; solute carrier family 6 member 1
              3 of 14
              SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, GABA), MEMBER 1; SLC6A1
               
              SLC6A2; solute carrier family 6 member 2
              3 of 14
              163970
              SLC6A3; solute carrier family 6 member 3
              3 of 14
              SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, DOPAMINE), MEMBER 3; SLC6A3
               
              SLC6A6; solute carrier family 6 member 6
              3 of 14
              186854
                SLC6A8; solute carrier family 6 member 8
                3 of 14
                300036
                SLC6A11; solute carrier family 6 member 11
                3 of 14
                607952
                    SLC6A12; solute carrier family 6 member 12
                    3 of 14
                    603080
                         
                        SLC6A13; solute carrier family 6 member 13
                        3 of 14
                        615097
                            SLC6A15; solute carrier family 6 member 15
                            3 of 14
                            607971
                                SLC6A16; solute carrier family 6 member 16
                                3 of 14
                                607972
                                    SLC6A17; solute carrier family 6 member 17
                                    3 of 14
                                    610299
                                    Functional Complementation Data
                                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                    Interactions
                                    Summary of Physical Interactions
                                    Interaction Browsers
                                    Summary of Genetic Interactions
                                    Interaction Browsers
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    Starting gene(s)
                                    Interaction type
                                    Interacting gene(s)
                                    Reference
                                    External Data
                                    Linkouts
                                    DroID - A comprehensive database of gene and protein interactions.
                                    Pathways
                                    Signaling Pathways (FlyBase)
                                    Metabolic Pathways
                                    FlyBase
                                    External Links
                                    External Data
                                    Linkouts
                                    Class of Gene
                                    Genomic Location and Detailed Mapping Data
                                    Chromosome (arm)
                                    2L
                                    Recombination map
                                    2-28
                                    Cytogenetic map
                                    28C1-28C1
                                    Sequence location
                                    FlyBase Computed Cytological Location
                                    Cytogenetic map
                                    Evidence for location
                                    28C1-28C1
                                    Limits computationally determined from genome sequence between P{EP}EP2419EP2419&P{EP}EP575 and P{PZ}l(2)rL220rL220
                                    Experimentally Determined Cytological Location
                                    Cytogenetic map
                                    Notes
                                    References
                                    Experimentally Determined Recombination Data
                                    Location

                                    2-28

                                    (FlyBase, 2016)

                                    2-25.0

                                    (Comeron et al., 2012)

                                    2-[24]

                                    Left of (cM)
                                    Right of (cM)
                                    Notes
                                    Stocks and Reagents
                                    Stocks (9)
                                    Genomic Clones (13)
                                     

                                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                    cDNA Clones (16)
                                     

                                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                    cDNA clones, fully sequenced
                                    BDGP DGC clones
                                    Other clones
                                    Drosophila Genomics Resource Center cDNA clones

                                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                    cDNA Clones, End Sequenced (ESTs)
                                    BDGP DGC clones
                                      Other clones
                                      RNAi and Array Information
                                      Linkouts
                                      Antibody Information
                                      Laboratory Generated Antibodies
                                       
                                      Commercially Available Antibodies
                                       
                                      Cell Line Information
                                      Publicly Available Cell Lines
                                       
                                        Other Stable Cell Lines
                                         
                                          Other Comments

                                          In Ntl mutant males, early stages of sperm development appear normal, but formation or unfurling of the nebenkern seems to be defective. During sperm individualization, actin investment cones form and move normally, but mitochondrial dynamics appear abnormal, with little or no "leading whorls" of mitochondrial material ahead of the actin cones.

                                          (Rollins et al., 2007)

                                          Promoter analysis of Mp suggests that the tRNA:Y1:28C coding region, that is located 300bp 5' from the Mp transcription start site, and/or the tRNA:Y1:28C leader sequences and the first 129 amino acids of the Mp coding region are required for the correct expression of Mp.

                                          (Kubli et al., 1991)
                                          Relationship to Other Genes
                                          Source for database merge of

                                          Source for merge of: Ntl Mp

                                          (FlyBase, 1992-)
                                          Additional comments

                                          Text of the sole reference (FBrf0066372) previously associated with 'Mp', together with the text of FBrf0129229, indicate that the unannotated 'Mp' gene corresponds to 'Ntl'.

                                          (FlyBase, 1992-)
                                          Nomenclature History
                                          Source for database identify of

                                          Source for identity of: Ntl CG7075

                                          (Rollins et al., 2007)
                                          Nomenclature comments
                                          Etymology
                                          Synonyms and Secondary IDs (7)
                                          Datasets (0)
                                          Study focus (0)
                                          Experimental Role
                                          Project
                                          Project Type
                                          Title
                                          Study result (0)
                                          Result
                                          Result Type
                                          Title
                                          External Crossreferences and Linkouts ( 32 )
                                          Sequence Crossreferences
                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                          Other crossreferences
                                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                          InterPro - A database of protein families, domains and functional sites
                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                          MARRVEL_MODEL - MARRVEL (model organism gene)
                                          Linkouts
                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                          DroID - A comprehensive database of gene and protein interactions.
                                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                          References (46)