Human Disease Model Report: alcohol, response to, stress-response genes

General Information

Name

alcohol, response to, stress-response genes

FlyBase ID

FBhh0000697

Disease Ontology Term

alcohol use disorder

Parent Disease

alcohol use disorder, susceptibility to (fly models overview)

OMIM

Overview

A number of the genes involved in behavioral alcohol responses in flies, affecting ethanol sensitivity and/or tolerance, are also implicated in response to environmental stress. These include hang, Jwa, and Tspo.

[updated Jan. 2018 by FlyBase; FBrf0222196]

Disease Summary Information

Parent Disease Summary: alcohol use disorder, susceptibility to (fly models overview)

Symptoms and phenotype

Alcoholism can be defined as persistence of excessive drinking over a long period of time despite adverse health effects and disruption of social relations (Morozova et al., 2014; pubmed:24395673).

(FlyBase Curators, 2013-)

The 2013 Diagnostic and Statistical Manual of Mental Disorders (DSM) combined the two former categorizations of abnormal alcohol use (alcohol abuse and alcohol dependence) into one diagnosis: alcohol use disorder. The severity of an individual's AUD is broken into classifications: mild, moderate, or severe. "Alcoholism" is a non-medical term often used to describe a severe form of alcohol use disorder. (https://www.therecoveryvillage.com/recovery-blog/alcoholism-alcohol-use-disorder-whats-difference/)

(FlyBase Curators, 2013-)

Excessive alcohol consumption is associated with increased risk of different types of cancer, higher cardiovascular disease mortality, birth defects, liver diseases, and neuropsychiatric disorders (Morozova et al., 2014; pubmed:24395673).

(FlyBase Curators, 2013-)

Alcoholism is a multifactorial, genetically influenced disorder. [from MIM:103780; 2017.12.19]

(OMIM, 2013-)

Specific Disease Summary: alcohol, response to, stress-response genes

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Genetics

Cellular phenotype and pathology

Molecular information

External links

Disease synonyms

AUD susceptibility, stress-response genes

Search term: alcohol use disorder

Related Diseases

Related human health report(s)

alcohol use disorder, susceptibility to (fly models overview)

Related Specific Diseases

OMIM phenotypic series

Disease

Associated Human gene(s)

Drosophila model

Human transgene in Drosophila

Ortholog Information

Human gene(s) in FlyBase

Other mammalian ortholog(s) used

D. melanogaster Gene Information (3)

Dmel\hang

Gene Snapshot

hangover (hang) encodes a nuclear zinc finger protein that is expressed in adult fly brain neurons. Lack of hang produces a reduction of Fas2 expression. Its roles include life span, bouton growth at the neuromuscular junction and regulation of cellular stress in response to ethanol, heat and paraquat. [Date last reviewed: 2019-03-07]

Molecular function (GO)

Cellular component (GO)

nucleus

Gene Groups / Pathways

ZF-C2H2

Comments on ortholog(s)

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Jwa

Gene Snapshot

Contributions welcome

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Dmel\Tspo

Gene Snapshot

Translocator protein (Tspo) encodes a protein localized in the outer mitochondrial membrane that is thought to be involved in various pathways, including steroid and heme biosynthesis, apoptosis, protein import, cell proliferation and differentiation and also has been proposed to participate in the formation of the mitochondrial permeability transition pore. [Date last reviewed: 2019-03-14]

Molecular function (GO)

Cellular component (GO)

Gene Groups / Pathways

Comments on ortholog(s)

Orthologs and Alignments from DRSC

DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans

H. sapiens (Human)

Other Genes Used: Viral, Bacterial, Synthetic (0)

Summary of Physical Interactions (59 groups)

hang

protein-protein

Interacting group

Assay

References

hang - MBD-R2

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry, molecular sieving

(Lenz et al., 2025)

hang - mof

anti tag coimmunoprecipitation, Identification by mass spectrometry, western blot, molecular sieving

(Lenz et al., 2025)

hang - Myc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

hang - nsl1

anti tag coimmunoprecipitation, western blot, Identification by mass spectrometry, molecular sieving

(Lenz et al., 2025)

hang - Rcd5

molecular sieving, western blot, anti tag coimmunoprecipitation, Identification by mass spectrometry

(Lenz et al., 2025)

hang - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

hang - ttk

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

RNA-protein

Interacting group

Assay

References

hang - G6pd

pull down, quantitative reverse transcription pcr

(Ruppert et al., 2017)

hang - Pde4

pull down, quantitative reverse transcription pcr

(Ruppert et al., 2017)

Jwa

protein-protein

Interacting group

Assay

References

Jwa - ATPsynδ

experimental knowledge based

(Guruharsha et al., 2011)

Jwa - ATPsynG

experimental knowledge based

(Guruharsha et al., 2011)

Jwa - ATPsynO

experimental knowledge based

(Guruharsha et al., 2011)

Jwa - CG7101

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Jwa - grp

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Jwa - Rer1

experimental knowledge based

(Guruharsha et al., 2011)

Jwa - snx

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Tspo

protein-protein

Interacting group

Assay

References

Tspo - Aprt

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Arf1

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Arl8

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - bbc

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - CCT6

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - CG1416

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - CG2070

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - CG13220

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - CG15098

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - CG32638

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Chc

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - COX4

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Gcs2β

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Ipo9

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Kr-h2

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - l(1)G0320

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Ldh

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Mcad

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Mec2

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - mt:CoII

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Ost1

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Ost48

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Ostc

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - ox

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Pdhb

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - porin

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Pp2A-29B

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Rab1

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Rab5

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Rab6

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Rab8

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Rap1

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Rdh1

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Rer1

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - ScsβA

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - ScsβG

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Sec13

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - SERCA

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - strat

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Tapδ

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - Tecr

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - UQCR-C2

experimental knowledge based

(Guruharsha et al., 2011)

Tspo - wal

experimental knowledge based

(Guruharsha et al., 2011)

Alleles Reported to Model Human Disease (Disease Ontology) (5 alleles)

hang

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

hang^AE10

model of alcohol use disorder

CEA

(Scholz et al., 2005)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

hang^AE10

model of alcohol use disorder

is exacerbated by Tbh^nM18

(Scholz et al., 2005)

Jwa

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Jwa^UAS.anti

model of alcohol use disorder

CEA

(Li et al., 2008)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Tspo

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Tspo^EY00814

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Lin et al., 2014)

Tspo^RNAi.UAS.cUa

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Lin et al., 2014)

Tspo^UAS.cRa

ameliorates Friedreich ataxia 1

modeled by fh^GAAs

(Jullian et al., 2024)

Alleles Representing Disease-Implicated Variants

Genetic Tools, Stocks and Reagents

Sources of Stocks

Contact lab of origin for a reagent not available from a public stock center.

Bloomington Stock Center Disease Page

Related mammalian, viral, bacterial, or synthetic transgenes

Allele

Transgene

Publicly Available Stocks

Selected Drosophila transgenes

Allele

Transgene

Publicly Available Stocks

RNAi constructs available

Allele

Transgene

Publicly Available Stocks

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05558}attP40

Jwa^GD1763

P{GD1763}

w¹¹¹⁸; P{GD1763}v6375

w¹¹¹⁸; P{GD12787}v23000

y¹ sc^* v¹ sev²¹; P{TRiP.GLV21039}attP2

y¹ sc^* v¹ sev²¹; P{TRiP.GL01300}attP40

hang^HMC04985

P{TRiP.HMC04985}

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04985}attP40

Selected Drosophila classical alleles

Allele

Allele class

Mutagen

Publicly Available Stocks

Tspo^EY00814

amorphic allele - molecular evidence

P-element activity

y¹ w^67c23; P{EPgy2}Tspo^EY00814

hang^AE10

References (15)

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