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Citation
Pool, A.H., Kvello, P., Mann, K., Cheung, S.K., Gordon, M.D., Wang, L., Scott, K. (2014). Four GABAergic interneurons impose feeding restraint in Drosophila.  Neuron 83(1): 164--177.
FlyBase ID
FBrf0225542
Publication Type
Research paper
Abstract

Feeding is dynamically regulated by the palatability of the food source and the physiological needs of the animal. How consumption is controlled by external sensory cues and internal metabolic state remains under intense investigation. Here, we identify four GABAergic interneurons in the Drosophila brain that establish a central feeding threshold which is required to inhibit consumption. Inactivation of these cells results in indiscriminate and excessive intake of all compounds, independent of taste quality or nutritional state. Conversely, acute activation of these neurons suppresses consumption of water and nutrients. The output from these neurons is required to gate activity in motor neurons that control meal initiation and consumption. Thus, our study reveals a layer of inhibitory control in feeding circuits that is required to suppress a latent state of unrestricted and nonselective consumption.

PubMed ID
PubMed Central ID
PMC4092013 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Alleles (29)
    Genes (16)
    Natural transposons (1)
    Insertions (10)
    Experimental Tools (2)
    Transgenic Constructs (23)
    Transcripts (9)