FB2025_01 , released February 20, 2025
Allele: Dmel\miGD11624
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General Information
Symbol
Dmel\miGD11624
Species
D. melanogaster
Name
FlyBase ID
FBal0204653
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing miGD11624 under the control of either Scer\GAL4sca.PU or Scer\GAL4pnr.PU show a reduction in the size of the thoracic macrochaetae compared to controls.

Adults expressing miGD11624 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in viable flies or early pupal lethality.

Expression under the control of Scer\GAL4pnr-MD237 results in loss of bristles on the notum in 0% or 20-30% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 20-30%, 60-70% or 100% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression of miGD11624 under the control of Scer\GAL4ptc-559.1 results in small salivary gland cells with small nuclei.

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

Scer\GAL4sca.PU, miGD11624 has visible phenotype, suppressible by CycEAR95/CycE[+]

Scer\GAL4pnr.PU, miGD11624 has visible phenotype, suppressible by CycEAR95/CycE[+]

Scer\GAL4sca.PU, miGD11624 has visible phenotype, suppressible by Cul4[+]/Cul46AP

Scer\GAL4sca.PU, miGD11624 has visible phenotype, suppressible by Cul4[+]/Cul4G1-3

Scer\GAL4sca.PU, miGD11624 has visible phenotype, suppressible by l(2)dtlc02261/l(2)dtl[+]

Scer\GAL4pnr.PU, miGD11624 has visible phenotype, suppressible by Cul4[+]/Cul4G1-3

Scer\GAL4pnr.PU, miGD11624 has visible phenotype, suppressible by l(2)dtlc02261/l(2)dtl[+]

NOT suppressed by
Statement
Reference

Scer\GAL4sca.PU, miGD11624 has visible phenotype, non-suppressible by Df(2R)cn9/+

Scer\GAL4sca.PU, miGD11624 has visible phenotype, non-suppressible by Df(2R)H3E1/+

Scer\GAL4sca.PU, miGD11624 has visible phenotype, non-suppressible by Cul4[+]/Cul4KG02900

Other
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

Scer\GAL4sca.PU, miGD11624 has macrochaeta phenotype, suppressible by CycEAR95/CycE[+]

Scer\GAL4pnr.PU, miGD11624 has macrochaeta phenotype, suppressible by CycEAR95/CycE[+]

Scer\GAL4sca.PU, miGD11624 has macrochaeta phenotype, suppressible by Cul4[+]/Cul46AP

Scer\GAL4sca.PU, miGD11624 has macrochaeta phenotype, suppressible by Cul4[+]/Cul4G1-3

Scer\GAL4sca.PU, miGD11624 has macrochaeta phenotype, suppressible by l(2)dtlc02261/l(2)dtl[+]

Scer\GAL4pnr.PU, miGD11624 has macrochaeta phenotype, suppressible by Cul4[+]/Cul4G1-3

Scer\GAL4pnr.PU, miGD11624 has macrochaeta phenotype, suppressible by l(2)dtlc02261/l(2)dtl[+]

NOT suppressed by
Statement
Reference

Scer\GAL4sca.PU, miGD11624 has macrochaeta phenotype, non-suppressible by Cul4[+]/Cul4KG02900

Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of miGD11624 and thScer\UAS.cHa under the control of Scer\GAL4en-e16E increases the number of cells in G2/M phase in the posterior compartment of wing imaginal discs beyond the modest increase seen when thScer\UAS.cHa alone is expressed.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Linkouts
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG5360GD11624
miGD11624
Name Synonyms
Secondary FlyBase IDs
    References (7)