FlyBase Allele Report: Dmel\Vps35[E42]

General Information

Symbol

Dmel\Vps35^E42

Species

D. melanogaster

Name

FlyBase ID

FBal0221801

Feature type

allele

Associated gene

Dmel\Vps35

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Port et al., 2008)

Progenitor genotype

P{EPgy2}Vps35^EY14200

(Port et al., 2008)

Cytology

Description

Imprecise excision of the progenitor insertion resulting in a 642bp deletion that removes part of the Vps35 transcription unit.

(Port et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:22,186,070..22,186,711 [+]

Comment:

642 bp deletion resulting from the imprecise excision of P{EPgy2}Vps35^EY14200

(Port et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Parkinson's disease

CEA with Vps35^MH20

(Malik et al., 2015)

CEA with park²⁵

(Malik et al., 2015)

DOES NOT model Parkinson's disease

CEA with Pink1^B9

(Malik et al., 2015)

model of brain cancer

CEA

(Li et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of brain cancer

is ameliorated by Delta^DN.UAS

(Li et al., 2018)

is ameliorated by Delta^DN.UAS

(Li et al., 2018)

is ameliorated by Delta^HMS01309

(Li et al., 2018)

is ameliorated by Hrs^UAS.cLa

(Li et al., 2018)

is ameliorated by N^GD14477

(Li et al., 2018)

is ameliorated by Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

is ameliorated by Psn^{527.D447A.UAS}

(Li et al., 2018)

is ameliorated by Rab5^S43N.UAS

(Li et al., 2018)

is ameliorated by Rab7^Q67L.UAS

(Li et al., 2018)

is ameliorated by Rab9^{Q71L.UASp.YFP}

(Li et al., 2018)

is ameliorated by Su(dx)^UAS.cCa

(Li et al., 2018)

is ameliorated by kuz^DN.UAS

(Li et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Parkinson's disease-related phenotypes are observed in Vps35^E42 park²⁵ double heterozygotes. No Parkinson's disease-related phenotypes are observed in Vps35^E42 Pink1^B9 double heterozygotes.

(Malik et al., 2015)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

intermediate neuronal progenitor | larval stage | increased number

(Li et al., 2018)

larval brain | larval stage

(Li et al., 2018)

larval neuroblast | larval stage | increased number

(Li et al., 2018)

late endosome | larval stage

(Li et al., 2018)

multivesicular body | larval stage

(Li et al., 2018)

NMJ bouton | increased number (with Vps35^MH20)

(Malik et al., 2015)

NMJ bouton | increased number | larval stage (with Df(2R)Exel6078)

(Walsh et al., 2021)

subsynaptic reticulum | larval stage (with Df(2R)Exel6078)

(Walsh et al., 2021)

synaptic vesicle | increased number | larval stage (with Df(2R)Exel6078)

(Walsh et al., 2021)

Detailed Description

Statement

Reference

Vps35^E42 mutant larvae exhibit supernumerary neuroblasts in the brain, which form tumors; transplantation of tumor tissue into the abdomen of host flies can results in large tumors that often metastasize to distant organs; the supernumerary neuroblasts do not show apparent defects in either cell polarity or asymmetric cell division (as assessed by the localization of Mira, aPKC and Numb during metaphase). Vps35^E42 mutant INPs/ectopic neuroblasts display dramatically enlarged Rab7-positive late endosomes/MVBs; there are no apparent defects in lysosomes (GFP-LAMP1-positive), recycling endosome (Rab11-positive), Golgi (GFP-Golgi-positive) or mitochondria (mito-GFP-positive).

(Li et al., 2018)

Vps35^MH20/Vps35^E42 mutants show supernumerary boutons and a dramatic reduction in larval locomotion.

Flies expressing Vps35^Scer\UAS.cMa under the control of Scer\GAL4^da.PU in a Vps35^MH20/Vps35^E42 mutant background show similar climbing ability to controls.

Flies expressing Vps35^{Scer\UAS.D650N} under the control of Scer\GAL4^da.PU in a Vps35^MH20/Vps35^E42 mutant background show climbing defects.

Flies expressing Vps35^{Scer\UAS.L800M} under the control of Scer\GAL4^da.PU in a Vps35^MH20/Vps35^E42 mutant background show similar climbing ability to controls.

Flies expressing Vps35^{Scer\UAS.R550W} under the control of Scer\GAL4^da.PU in a Vps35^MH20/Vps35^E42 mutant background show climbing defects.

(Malik et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/wg^HMS00794

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/wg^HMS00794

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Rab5^UASp.YFP/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Rab5^UASp.YFP/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab5^UASp.YFP

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab5^UASp.YFP

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Rab5^{Q88L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Rab5^{Q88L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Egfr^DN.UAS.cBa

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^pnt-14-94/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^pnt-14-94/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Rab7^{T22N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Egfr^DN.UAS.cBa

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Rab7^{T22N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab7^{T22N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab7^{T22N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Rab11^{S25N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Rab11^{S25N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab11^{S25N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab11^{S25N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Med^JF02218

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Hrs^HMS00841

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Hrs^HMS00841

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Hrs^HMS00841/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Med^JF02218

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Hrs^HMS00841/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Suppressed by

Statement

Reference

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Rab9^{Q71L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^pnt-14-94/Rab7^Q67L.UAS

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab7^Q67L.UAS

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Hrs^UAS.cLa/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^pnt-14-94/Rab5^S43N.UAS

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab5^S43N.UAS

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab9^{Q71L.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/N^GD14477

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Delta^HMS01309/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Delta^HMS01309/Scer\GAL4^GMR9D11

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by kuz^DN.UAS/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by kuz^DN.UAS/Scer\GAL4^GMR9D11

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Psn^{527.D447A.UAS}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/ptc^{1130X.UAS.YFP}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Delta^HMS01309

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Rab9^{Q71L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^pnt-14-94/Rab7^Q67L.UAS

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab7^Q67L.UAS

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Hrs^UAS.cLa/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^pnt-14-94/Rab5^S43N.UAS

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab5^S43N.UAS

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab9^{Q71L.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Hsap\VPS35^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Hsap\VPS35^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has neoplasia | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Hsap\VPS35^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/N^GD14477

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Delta^HMS01309/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Delta^HMS01309/Scer\GAL4^GMR9D11

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by kuz^DN.UAS/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by kuz^DN.UAS/Scer\GAL4^GMR9D11

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Psn^{527.D447A.UAS}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/ptc^{1130X.UAS.YFP}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Delta^HMS01309

(Li et al., 2018)

Vps35^E42 has abnormal size | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/N^GD14477

(Li et al., 2018)

Vps35^MH20/Vps35^E42 has abnormal locomotor behavior | larval stage phenotype, suppressible by Scer\GAL4^da.PU/Hsap\VPS35^UAS.cMa

(Malik et al., 2015)

Vps35^MH20/Vps35^E42 has abnormal locomotor behavior | larval stage phenotype, suppressible | partially by Scer\GAL4^da.PU/Hsap\VPS35^D620N.UAS

(Malik et al., 2015)

Vps35^MH20/Vps35^E42 has abnormal locomotor behavior | larval stage phenotype, suppressible | partially by Scer\GAL4^da.PU/Hsap\VPS35^R524W.UAS

(Malik et al., 2015)

Vps35^MH20/Vps35^E42 has abnormal locomotor behavior | larval stage phenotype, suppressible | partially by Scer\GAL4^da.PU/Hsap\VPS35^L774M.UAS

(Malik et al., 2015)

NOT suppressed by

Statement

Reference

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab5^UASp.YFP

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Rab5^{Q88L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^pnt-14-94/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Rab7^{T22N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab7^{T22N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Rab11^{S25N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab11^{S25N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Hrs^HMS00841

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Hrs^HMS00841/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/wg^HMS00794

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Egfr^DN.UAS.cBa

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Med^JF02218

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Rab5^UASp.YFP/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab5^UASp.YFP

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Rab5^{Q88L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^pnt-14-94/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Rab7^{T22N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab7^{T22N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Rab11^{S25N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab11^{S25N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/wg^HMS00794

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Hrs^HMS00841

(Li et al., 2018)

Vps35^E42 has abnormal neuroanatomy | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Hrs^HMS00841/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Egfr^DN.UAS.cBa

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Med^JF02218

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has increased cell number | larval stage phenotype, non-suppressible by Rab5^UASp.YFP/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^MH20/Vps35^E42 has lethal phenotype, non-suppressible by Scer\GAL4^da.PU/Hsap\VPS35^UAS.cMa

(Malik et al., 2015)

Vps35^MH20/Vps35^E42 has lethal phenotype, non-suppressible by Scer\GAL4^da.PU/Hsap\VPS35^D620N.UAS

(Malik et al., 2015)

Vps35^MH20/Vps35^E42 has lethal phenotype, non-suppressible by Scer\GAL4^da.PU/Hsap\VPS35^R524W.UAS

(Malik et al., 2015)

Vps35^MH20/Vps35^E42 has lethal phenotype, non-suppressible by Scer\GAL4^da.PU/Hsap\VPS35^L774M.UAS

(Malik et al., 2015)

Other

Statement

Reference

Vps35^E42, park[+]/park²⁵ has abnormal oxidative stress response phenotype

(Malik et al., 2015)

Vps35^E42, park[+]/park²⁵ has abnormal locomotor behavior | adult stage | progressive phenotype

(Malik et al., 2015)

Hsap\VPS35^UAS.cMa, Scer\GAL4^da.PU, Vps35^MH20/Vps35^E42 has majority die during pupal stage phenotype

(Malik et al., 2015)

Hsap\VPS35^D620N.UAS, Scer\GAL4^da.PU, Vps35^MH20/Vps35^E42 has majority die during pupal stage phenotype

(Malik et al., 2015)

Hsap\VPS35^R524W.UAS, Scer\GAL4^da.PU, Vps35^MH20/Vps35^E42 has majority die during pupal stage phenotype

(Malik et al., 2015)

Hsap\VPS35^L774M.UAS, Scer\GAL4^da.PU, Vps35^MH20/Vps35^E42 has majority die during pupal stage phenotype

(Malik et al., 2015)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Med^JF02218

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/wg^HMS00794

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Rab5^UASp.YFP/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Rab5^UASp.YFP/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab5^UASp.YFP

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab5^UASp.YFP

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Rab5^{Q88L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Rab5^{Q88L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^pnt-14-94/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^pnt-14-94/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Rab7^{T22N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Rab7^{T22N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab7^{T22N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab7^{T22N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Rab11^{S25N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Egfr^DN.UAS.cBa

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Rab11^{S25N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab11^{S25N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Rab11^{S25N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Egfr^DN.UAS.cBa

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Hrs^HMS00841

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Hrs^HMS00841

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Hrs^HMS00841/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Hrs^HMS00841/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage | increased number phenotype, non-enhanceable by Scer\GAL4^insc-Mz1407/Med^JF02218

(Li et al., 2018)

Suppressed by

Statement

Reference

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Hsap\VPS35^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Hsap\VPS35^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/N^GD14477

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Delta^HMS01309/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Delta^HMS01309/Scer\GAL4^GMR9D11

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by kuz^DN.UAS/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by kuz^DN.UAS/Scer\GAL4^GMR9D11

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Psn^{527.D447A.UAS}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/ptc^{1130X.UAS.YFP}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Delta^HMS01309

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^pnt-14-94/Rab5^S43N.UAS

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab5^S43N.UAS

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab9^{Q71L.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Rab9^{Q71L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^pnt-14-94/Rab7^Q67L.UAS

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab7^Q67L.UAS

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Hrs^UAS.cLa/Scer\GAL4^pnt-14-94

(Li et al., 2018)

FBal0278258:, Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Scer\GAL4^insc-Mz1407

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/N^GD14477

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Delta^HMS01309/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Delta^HMS01309/Scer\GAL4^GMR9D11

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by kuz^DN.UAS/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by kuz^DN.UAS/Scer\GAL4^GMR9D11

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Psn^{527.D447A.UAS}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/wg^HMS00794

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/ptc^{1130X.UAS.YFP}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Delta^HMS01309

(Li et al., 2018)

Vps35^E42 has endosome | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/N^GD14477

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^pnt-14-94/Rab5^S43N.UAS

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Rab9^{Q71L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab9^{Q71L.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^pnt-14-94/Rab7^Q67L.UAS

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab7^Q67L.UAS

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Hrs^UAS.cLa/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab5^S43N.UAS

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab5^S43N.UAS

(Li et al., 2018)

Vps35^E42 has endosome | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab5^S43N.UAS

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab9^{CA.UAS.Tag:HA}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab9^{CA.UAS.Tag:HA}

(Li et al., 2018)

Vps35^E42 has endosome | increased number | larval stage phenotype, suppressible by Scer\GAL4^insc-Mz1407/Rab9^{CA.UAS.Tag:HA}

(Li et al., 2018)

NOT suppressed by

Statement

Reference

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/wg^HMS00794

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Egfr^DN.UAS.cBa

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Med^JF02218

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Egfr^DN.UAS.cBa

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Med^JF02218

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Rab5^UASp.YFP/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab5^UASp.YFP

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Rab5^{Q88L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^pnt-14-94/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Rab7^{T22N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab7^{T22N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Rab11^{S25N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab11^{S25N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Rab5^UASp.YFP/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab5^UASp.YFP

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Rab5^{Q88L.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^pnt-14-94/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab9^{S26N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Rab7^{T22N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab7^{T22N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Rab11^{S25N.UASp.YFP}/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Rab11^{S25N.UASp.YFP}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Nedd4^{UAS.cLa.Tag:MYC}/Su(dx)^UAS.cCa

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Hrs^HMS00841

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Hrs^HMS00841

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has larval neuroblast | increased number | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Hrs^HMS00841/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Ndfip^UAS.Tag:FLAG/Hrs^HMS00840

(Li et al., 2018)

Vps35^E42 has larval brain | larval stage phenotype, non-suppressible by Scer\GAL4^insc-Mz1407/Su(dx)^UAS.cCa/Hrs^HMS00841/Ndfip^UAS.Tag:FLAG

(Li et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Vps35^E42 park²⁵ double heterozygotes show an age-dependent reduction in climbing ability. No phenotypes are observed in either heterozygote alone.

Vps35^E42 park²⁵ double heterozygotes show increased sensitivity to the oxidative stressor paraquat compared with either heterozygote alone, similar to that seen in park²⁵ homozygotes.

Vps35^E42 Pink1^B9 double heterozygotes do not exhibit climbing defects.

(Malik et al., 2015)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\VPS35^Scer\UAS.cMa under the control of Scer\GAL4^da.PU at 25[o] fails to suppress the phenotypes seen in Vps35^MH20/Vps35^E42 mutant flies. Expressing Hsap\VPS35^Scer\UAS.cMa at 29[o]C rescues mutant viability to the late pupal stage, but adults fail to eclose.

Expression of Hsap\VPS35^Scer\UAS.cMa under the control of Scer\GAL4^da.PU suppresses the larval locomotion defects seen in Vps35^MH20/Vps35^E42 mutants.

Expression of Hsap\VPS35^Scer\UAS.cMa under the control of Scer\GAL4^da.PU at 29[o] suppresses the NMJ phenotypes seen in Vps35^MH20/Vps35^E42 mutant larvae.

Expression of Hsap\VPS35^{D620N.Scer\UAS} under the control of Scer\GAL4^da.PU at 25[o] fails to suppress the phenotypes seen in Vps35^MH20/Vps35^E42 mutant flies. Expressing Hsap\VPS35^{D620N.Scer\UAS} at 29[o]C rescues mutant viability to the late pupal stage, but adults fail to eclose.

Expression of Hsap\VPS35^{D620N.Scer\UAS} under the control of Scer\GAL4^da.PU partially suppresses the larval locomotion defects seen in Vps35^MH20/Vps35^E42 mutants.

Expression of Hsap\VPS35^{D620N.Scer\UAS} under the control of Scer\GAL4^da.PU at 29[o] suppresses the NMJ phenotypes seen in Vps35^MH20/Vps35^E42 mutant larvae.

Expression of Hsap\VPS35^{R524W.Scer\UAS} under the control of Scer\GAL4^da.PU at 25[o] fails to suppress the phenotypes seen in Vps35^MH20/Vps35^E42 mutant flies. Expressing Hsap\VPS35^{R524W.Scer\UAS} at 29[o]C rescues mutant viability to the late pupal stage, but adults fail to eclose.

Expression of Hsap\VPS35^{R524W.Scer\UAS} under the control of Scer\GAL4^da.PU partially suppresses the larval locomotion defects seen in Vps35^MH20/Vps35^E42 mutants.

Expression of Hsap\VPS35^{R524W.Scer\UAS} under the control of Scer\GAL4^da.PU at 29[o] suppresses the NMJ phenotypes seen in Vps35^MH20/Vps35^E42 mutant larvae.

Expression of Hsap\VPS35^{L774M.Scer\UAS} under the control of Scer\GAL4^da.PU at 25[o] fails to suppress the phenotypes seen in Vps35^MH20/Vps35^E42 mutant flies. Expressing Hsap\VPS35^{L774M.Scer\UAS} at 29[o]C rescues mutant viability to the late pupal stage, but adults fail to eclose.

Expression of Hsap\VPS35^{L774M.Scer\UAS} under the control of Scer\GAL4^da.PU partially suppresses the larval locomotion defects seen in Vps35^MH20/Vps35^E42 mutants.

Expression of Hsap\VPS35^{L774M.Scer\UAS} under the control of Scer\GAL4^da.PU at 29[o] suppresses the NMJ phenotypes seen in Vps35^MH20/Vps35^E42 mutant larvae.

(Malik et al., 2015)

Complementation and Rescue Data

Rescued by

Vps35^E42 is rescued by Scer\GAL4^insc-Mz1407/Vps35^UAS.Tag:FLAG

(Li et al., 2018)

Vps35^E42 is rescued by Vps35^UAS.Tag:FLAG/Scer\GAL4^pnt-14-94

(Li et al., 2018)

Vps35^MH20/Vps35^E42 is rescued by Scer\GAL4^da.PU/Vps35^UAS.cMa

(Malik et al., 2015)

Partially rescued by

Vps35^E42 is partially rescued by Vps35^UAS.Tag:FLAG/Scer\GAL4^GMR9D11

(Li et al., 2018)

Vps35^MH20/Vps35^E42 is partially rescued by Scer\GAL4^da.PU/Vps35^UAS.D650N

(Malik et al., 2015)

Vps35^MH20/Vps35^E42 is partially rescued by Scer\GAL4^da.PU/Vps35^UAS.R550W

(Malik et al., 2015)

Vps35^MH20/Vps35^E42 is partially rescued by Vps35^UAS.L800M/Scer\GAL4^da.PU

(Malik et al., 2015)

Not rescued by

Vps35^E42 is not rescued by Vps35^UAS.Tag:FLAG/Scer\GAL4^ase.neuro

(Li et al., 2018)

Comments

The neuroblast brain tumor phenotype of Vps35^E42 larvae is fully or partially rescued by the Scer\GAL4^GMR9D11-driven expression of Vps35^UAS.Tag:FLAG, depending on the Scer\GAL4^GMR9D11 insertion.

(Li et al., 2018)

Expression of Vps35^Scer\UAS.cMa under the control of Scer\GAL4^da.PU at 25[o] fails to rescue the phenotypes seen in Vps35^MH20/Vps35^E42 mutant flies. Expressing Vps35^Scer\UAS.cMa at 29[o]C prevents the appearance of melanotic masses and fully rescues the developmental lethality, with progeny appearing in expected proportions.

Expression of Vps35^Scer\UAS.cMa under the control of Scer\GAL4^da.PU at 29[o] rescues the NMJ phenotypes seen in Vps35^MH20/Vps35^E42 mutant larvae.

Expression of Vps35^Scer\UAS.cMa under the control of Scer\GAL4^da.PU rescues the larval locomotion defects seen in Vps35^MH20/Vps35^E42 mutants.

Expression of Vps35^{Scer\UAS.D650N} under the control of Scer\GAL4^da.PU at 25[o] fails to rescue the phenotypes seen in Vps35^MH20/Vps35^E42 mutant flies. Expressing Vps35^{Scer\UAS.D650N} at 29[o]C prevents the appearance of melanotic masses and fully rescues the developmental lethality, with progeny appearing in expected proportions.

Expression of Vps35^{Scer\UAS.D650N} under the control of Scer\GAL4^da.PU at 29[o] rescues the NMJ phenotypes seen in Vps35^MH20/Vps35^E42 mutant larvae.

Expression of Vps35^{Scer\UAS.D650N} under the control of Scer\GAL4^da.PU partially rescues the larval locomotion defects seen in Vps35^MH20/Vps35^E42 mutants.

Expression of Vps35^{Scer\UAS.L800M} under the control of Scer\GAL4^da.PU at 25[o] fails to rescue the phenotypes seen in Vps35^MH20/Vps35^E42 mutant flies. Expressing Vps35^{Scer\UAS.L800M} at 29[o]C prevents the appearance of melanotic masses and fully rescues the developmental lethality, with progeny appearing in expected proportions.

Expression of Vps35^{Scer\UAS.L800M} under the control of Scer\GAL4^da.PU at 29[o] rescues the NMJ phenotypes seen in Vps35^MH20/Vps35^E42 mutant larvae.

Expression of Vps35^{Scer\UAS.L800M} under the control of Scer\GAL4^da.PU partially rescues the larval locomotion defects seen in Vps35^MH20/Vps35^E42 mutants.

Expression of Vps35^{Scer\UAS.R550W} under the control of Scer\GAL4^da.PU at 25[o] fails to rescue the phenotypes seen in Vps35^MH20/Vps35^E42 mutant flies. Expressing Vps35^{Scer\UAS.R550W} at 29[o]C prevents the appearance of melanotic masses and fully rescues the developmental lethality, with progeny appearing in expected proportions.

Expression of Vps35^{Scer\UAS.R550W} under the control of Scer\GAL4^da.PU at 29[o] rescues the NMJ phenotypes seen in Vps35^MH20/Vps35^E42 mutant larvae.

Expression of Vps35^{Scer\UAS.R550W} under the control of Scer\GAL4^da.PU partially rescues the larval locomotion defects seen in Vps35^MH20/Vps35^E42 mutants.

(Malik et al., 2015)

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Mutant

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Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dvps35^E42

(Port et al., 2008)

Vps35^E42

(Malik et al., 2015)

Vps35^e42

(Walsh et al., 2021)

vps35^E42

(Li et al., 2018, Lee and Fischer, 2012)

Name Synonyms

Secondary FlyBase IDs

References (5)

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