Reference Report

Reference
Citation	Andrews, H.K., Giagtzoglou, N., Yamamoto, S., Schulze, K.L., Bellen, H.J. (2009). Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila. EMBO Rep. 10(6): 636--641. (Export to RIS)
FlyBase ID	FBrf0208172
Publication Type	Research paper
PubMed ID	19444309
PubMed Abstract	The adult Drosophila external sensory organ (ESO), comprising the hair, socket, neuron, sheath and glia cells, arises through the asymmetric division of sensory organ precursor cells (SOPs). In a mosaic screen designed to identify new components in ESO development, we isolated mutations in sequoia, which encodes a putative zinc-finger transcription factor that has previously been shown to have a role in dendritogenesis. Here, we show that adult clones mutant for seq exhibit a loss of hair cells and a gain of socket cells. We propose that the seq mutant phenotype arises, in part, owing to the loss of several crucial transcription factors known to be important in peripheral nervous system development such as D-Pax2, Prospero and Hamlet. Thus, Sequoia is a new upstream regulator of genes that orchestrates cell fate specification during development of the adult ESO lineage.
DOI	10.1038/embor.2009.66
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO Rep.
Title	EMBO Reports
Publication Year	2000-
ISBN/ISSN
Data from Reference
Aberrations (1)
	Df(2R)Exel8057
Alleles (15)
	ham^Scer\UAS.cMa ham^unspecified N^l1N-ts1 numb^{PTB.Scer\UAS.T:Avic\GFP} pros¹⁷ pros^Scer\UAS.cMa Scer\GAL4^{neur-GAL4-A101} Scer\GAL4^tub.PU seq²² seq^A41 seq^N22 seq^Q8 seq^R1 seq^U5 sv^Scer\UAS.cKa
Constructs (5)
	P{tub-GAL4.U} P{UAS-ham.M} P{UAS-numb.PTB.GFP} P{UAS-pros.17K-2} P{UAS-sv.K}
Genes (14)
	ct dpn elav ham N neur numb pros Scer\GAL4 sens seq Su(H) sv ttk
Insertions (1)
	P{GawB}neur^GAL4-A101