Reference Report

Reference
Citation	Svendsen, P.C., Formaz-Preston, A., Leal, S.M., Brook, W.J. (2009). The Tbx20 homologs midline and H15 specify ventral fate in the Drosophila melanogaster leg. Development 136(16): 2689--2693. (Export to RIS)
FlyBase ID	FBrf0208458
Publication Type	Research paper
PubMed ID	19605497
PubMed Abstract	Regional fates in the developing limbs of Drosophila melanogaster are controlled by selector gene transcription factors. Ventral fate in the fly leg is specified by the expression of the ligand Wingless. We present evidence that midline and H15, members of the Tbx20 class of T-box transcription factors, are key mediators of the Wingless signal in the formation of the ventral region of the fly leg. midline and H15 are restricted to identical ventral domains of expression through activation by Wingless and repression by the dorsal signal Decapentaplegic. midline and H15 function redundantly and cell autonomously in the formation of ventral-specific structures. Conversely, midline is sufficient to induce ventral fate. Finally, the induction of ectopic ventral fate by mid is compromised when Wingless signaling is attenuated, suggesting that Wingless acts both upstream and in parallel with midline/H15 to specify ventral fate. Based on these results, we propose that midline and H15 may be considered as the selector genes for ventral leg fate.
DOI	10.1242/dev.037911
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(2L)H15-x4
Alleles (10)
	Ecol\lacZ^bi-Pol-1 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^H15-H-15 mid¹ mid^1a5 mid^Scer\UAS.cBa Mmus\Lef1^Scer\UAS.cRa Scer\GAL4^Act5C.PI Scer\GAL4^bi-omb-Gal4 Scer\GAL4^{Scer\FRT.Act5C}
Constructs (5)
	P{Act5C-GAL4} P{AyGAL4} P{BS3.0} P{UAS.LEF-1} P{UAS-mid.B}
Genes (11)
	arm bi dpp Ecol\lacZ H15 mid Mmus\Lef1 Scer\GAL4 Scr wg y
Insertions (3)
	P{GAL4}bi^omb-Gal4 P{lacW}bi^Pol-1 P{PZ}H-15