FB2026_02 , released June 18, 2026
Aberration: Dmel\Df(1)260-1
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General Information
Symbol
Df(1)260-1
Species
D. melanogaster
Name
FlyBase ID
FBab0000224
Feature type
chromosomal_deletion
Also Known As
Df(1)260.1
Computed Breakpoints include

1A1;1B4

Features within 1A1--1B4
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
spontaneous
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Duffy et al., 1996, Pauli et al., 1995, Kimura et al., 1985, Garcia-Bellido and Robbins, 1983, White et al., 1983, Sutton, 1943)
Breakpoints

1A1;1B3-1B4

(Sutton, 1943)

XLt;1B6-1B7

(Garcia-Bellido and Robbins, 1983)

1A1;1B4-1B7

(White et al., 1983)

[];1B4--6

(Ray and Rodrigues, 1994, Sherald and Voelker, 1985)

XLt;1B4-1B6

(Kimura et al., 1985)

1A1;1B4-1B6

(Duffy et al., 1996, Pauli et al., 1995)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << pch << Exp6 << bk2 << svr

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(Ruiz-Gomez and Ghysen, 1993, Gonzalez et al., 1989)
Comments on Cytology

Limits of break 1 from polytene analysis (FBrf0005951) Left limit of break 2 from inclusion of Cyp4g1 (FBrf0054051) Right limit of break 2 from polytene analysis (FBrf0005951)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations

    Fewer cells enlarge in the embryonic ventral neuroectoderm before delamination of the SI neuroblasts compared to wild-type embryos; 33% in the medial, 4% in the intermediate and 11% in the lateral region (wild-type numbers are 63%, 20% and 64% respectively). Prior to the delamination of the SII neuroblasts, when in the wild-type neurectoderm the cells of the intermediate regions enlarge, there is almost no increase in cell size in corresponding regions in Df(1)260-1 embryos.

    (Stollewerk, 2000)
    NOT in combination with other aberrations

    Df(1)260-1 clones in the wing margin produce bristles with an abnormal morphology.

    Thoracic Df(1)260-1 clones are devoid of bristles. Coexpression of sensUAS.cNa and daUAS.cGa, under the control of Scer\GAL4Eq, results in the formation of bristles in these clones.

    (Jafar-Nejad et al., 2006)

    The bristle phenotype seen female D.simulans/D.melanogaster hybrids is significantly exacerbated by the Df(1)260-1 deletion, which removes the achaete-scute complex.

    (Skaer and Simpson, 2000)

    The ventral cord of hemizygous embryos is strongly fragmented and all external sensory organs of the trunk are missing. Neural hypoplasia of the CNS and PNS are strongly reduced by Scer\GAL4da.G32-mediated expression of l(1)scUAS.cHa.

    (Giebel et al., 1997)

    Df(1)260-1 clones produce normal numbers of olfactory sensilla on the surface of the third antennal segment, although some of these sensilla are smaller than normal and are morphologically abnormal.

    (Reddy et al., 1997)

    Dominantly causes tergite defects in less than 50% of run3 heterozygotes.

    (Duffy et al., 1996)

    Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)

    Embryos lack all es organs but ch organs develop normally (FBrf0046281). P{hsp(sE)-poxn} expression can lead to the formation of external structures typical of es organs.

    (Vervoort et al., 1995)

    Hemizygous clones in the labellum lack all taste bristles; the taste pegs as well as the pseudotracheal structures are absent.

    (Ray and Rodrigues, 1994)

    In heterozygous females the deletion acts as a dominant suppressor of h and emc. All es and most of the nd neurons are removed, ch neurons are not affected.

    (del Prado and Garcia-Bellido, 1984)

    homozygous lethal

    (Garcia-Bellido and Robbins, 1983)

    Lethal in homozygous and hemizygous condition.

    (Sutton, 1943)

    male lethal somatic cell viable Germ-line clones lethal (Garcia-Bellido and Robbins, 1983, Genetics 103: 235-47). Eliminates all external sense organs in embryo (Dambly-Chaudiere and Ghysen, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 222-28).

    Stocks (2)
    Notes on Origin
    Discoverer

    Demerec and Hoover, 1936.

    (Sutton, 1943)
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (6)
    References (55)