FlyBase Allele Report: Dmel\mys[olfC-x17]

General Information

Symbol

Dmel\mys^olfC-x17

Species

D. melanogaster

Name

FlyBase ID

FBal0013251

Feature type

allele

Associated gene

Dmel\mys

Associated Insertion(s)

Carried in Construct

Also Known As

olfC^X17

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Cobb and Dannet, 1994)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

neuromuscular junction

(Beumer et al., 2002)

neuromuscular junction (with mys¹¹)

(Beumer et al., 2002)

Detailed Description

Statement

Reference

In the odour-induced jump test, homozygous mutants of mys^olfC-x5 are defective in response to iso-amyl acetate but not benzaldehyde or ethyl acetate, when compared to controls.

(Ayyub and Paranjape, 2002)

mys^olfC-x17 and mys^olfC-x17/mys¹¹ synapses at the larval neuromuscular junction show overgrowth.

(Beumer et al., 2002)

Mutants exhibit reduced olfactory responses to isoamyl acetate, whether homozygous or in combination with mys^olfC-x3, mys^olfC-x10 or mys^olfC-x5. Homozygous mutants are wild-type in response to ethyl acetate, but show a reduced response in combination with mys^olfC-x3 and mys^olfC-x10.

(Ayyub et al., 2000)

Larvae show a reduced response to iso-pentyl acetate. Larvae show abnormal responses to certain acetates. Larvae are repulsed at high volumes and indifferent to low volumes of hexyl acetate.

(Cobb and Dannet, 1994)

No significant differences between wild type and mys^olfC-x17 larval response to ethanol, hexanol and nonanol.

(Cobb et al., 1992)

Homozygous adults show a reduced attraction to iso-amyl acetate compared to wild-type in a slow chemotaxis assay and an odor-induced jump assay, although they appear to detect ethyl acetate normally. Homozygous larvae also show a reduced attraction to iso-amyl acetate but not ethyl acetate. Responses of larvae and adults to benzaldehyde, propionic acid and butanol are normal. mys^olfC-x10/mys^olfC-x17 and mys^olfC-x17/Df(1)C128 flies are defective in their responses to both ethyl acetate and iso-amyl acetate.

(Ayyub et al., 1990)

normal response to ethyl acetate; reduced to iso-amyl acetate mys^olfC-x17 female hemizygotes defective in responses to both ethyl and iso-amyl acetates, whereas, this allele in homozygous females allows for normal responses to ethyl acetate.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

mys^olfC-x17 has abnormal smell perception | recessive phenotype, enhanceable by e(olfC)^1a

(Ayyub et al., 1990)

Suppressed by

Statement

Reference

mys^olfC-x17, sws^olfE-x26 has abnormal smell perception phenotype, suppressible by sws^olfE-E2

(Ayyub and Paranjape, 2002)

mys^olfC-x17, sws^olfE-x26 has abnormal smell perception phenotype, suppressible | partially by mys^hs.PBu

(Ayyub and Paranjape, 2002)

mys^olfC-x17 has abnormal smell perception | male phenotype, suppressible by sws^olfE-E2

(Ayyub and Paranjape, 2002)

Other

Statement

Reference

mew^M6, mys[+]/mys^olfC-x17 has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

mys^olfC-x17, sws^olfE-x26 has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

Df(1)C128, mys^olfC-x17 has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

mew^M6, mys^olfC-x17 has abnormal smell perception phenotype

(Ayyub and Paranjape, 2002)

if^k27e, mys^olfC-x17 has abnormal smell perception phenotype

(Ayyub et al., 2000)

if^B2, mys^olfC-x17 has abnormal smell perception phenotype

(Ayyub et al., 2000)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

In the odour-induced jump test, the transheterozygous combination of mys^olfC-x17 with sws^olfE-x26 show a reduced response to both iso-amyl acetate and benzaldehyde but a normal response to ethyl acetate, compared to controls.

Mutants with mys^olfC-x17 in transheterozygosity to Df(1)C128 (which removes both sws and mys) show defects in response to iso-amyl acetate but not benzaldehyde compared to controls, when tested in the odour-induced jump test.

When tested in the odour-induced jump-test, hemizygous males of mys^olfC-x17 carrying sws^olfE-E2 show a reduced response to iso-amyl acetate but not benzaldehyde compared to controls.

When tested in the odour-induced jump-test, double heterozygotes of mew^M6 and mys^olfC-x17 show reduced responses to both ethyl acetate and iso-amyl acetate.

When tested in the odour-induced jump-test, sws^olfE-E2 rescues the reduced response to iso-amyl acetate and benzaldehyde observed in mys^olfC-x17/sws^olfE-x26 transheterozygotes.

When tested in the odour-induced jump test, mutants with the heteroallelic combination of mys^olfC-x17 and sws^olfE-x26 with mys^hs.PBu show slightly less severely defective responses to iso-amyl acetate and benzaldehyde compared to mys^olfC-x17 and sws^olfE-x26 alone.

(Ayyub and Paranjape, 2002)

mys^olfC-x17 e(olfC)^1a double homozygotes (referred to as strain olfC^x17-1a) have a stronger phenotype than mys^olfC-x17 single homozygotes; the defect in response to iso-amyl acetate is stronger, and there is a reduction in response to benzaldehyde and ethyl acetate in an olfactory jump assay.

(Ayyub et al., 1990)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

mys^{olfC-A459.1F1}

(Ayyub et al., 2000)

mys¹⁰

(Ayyub et al., 2000)

mys⁸

(Ayyub et al., 2000)