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General Information
Symbol
Dmel\hidA206
Species
D. melanogaster
Name
FlyBase ID
FBal0045273
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C18173104T

Reported nucleotide change:

C1181T

Amino acid change:

S261L | hid-PA; S261L | hid-PB

Reported amino acid change:

S261L

Comment:

One of two amino acid changes observed in Whid-A206.

point mutation
Nucleotide change:

C18173066T

Reported nucleotide change:

C715T

Amino acid change:

Q274term | hid-PA; Q274term | hid-PB

Reported amino acid change:

Q274term

Comment:

One of two amino acid changes observed in Whid-A206

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution: C?T.

Amino acid replacement: S261L.

Amino acid replacement: Q274term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

hidA206/+ third instar larvae show no defects in the field coverage and branching of the dendritic arbor in class IV dendritic arborizing neurons compared to controls but dendrite pruning of these neurons normally occurring during pupariation is in hidA206 heterozygote pupae.

Whid-A206/Df(3L)H99 have on average 5 "neurons medially located, just above antennal lobe" (mALs), comparable to 5 in wild-type females. The number in males (~30) is also unaffected.

Stage 16 mutant female Whid-A206/Df(3L)H99 mutant embryos have male-specific somatic gonadal precursors in the posterior of the gonad, although the cluster of these cells is slightly smaller than in wild-type males.

Homozygotes display significantly reduced viability. Pronounced defect in the morphogenetic movements of head involution which results, in part, from a failure of the dorsal fold to migrate anteriorly. Otherwise the segmented cuticle is normal and individuals reach advanced stages. There is less apoptosis when compared to wild type, most noticeably in the head region prior to completion of head involution.

Surviving transheterozygotes with Whid-A22 or Whid-A206 have an abnormal wing phenotype. The mutant wing appears opaque by comparison to wild type and occasionally contains trapped fluid. Transheterozygous males also possess improperly positioned terminalia. Some hemizygotes die before hatching and most of those that hatch possess properly formed cephalopharyngeal skeleton.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

hidA206/hid[+] is a suppressor of dendrite | third instar larval stage phenotype of nos53/nos18

hidA206/W[+] is a suppressor of eye phenotype of Scer\GAL4GMR.PF, rprUTR.UAS.Tag:HA

Additional Comments
Genetic Interactions
Statement
Reference

The dendritic field coverage defects and loss of terminal branches as well as the increased branch retraction rate observed in class IV dendritic arborizing neurons of third instar larvae expressing nosdsRNA.Scer\UAS.WIZ under the control of Scer\GAL4477 is suppressed by combination with a single copy of hidA206 as is the increased density of mitochondria in dendrites observed with the RNAi driven by Scer\GAL4ppk.1.9.

The dendritic field coverage and branching defects observed in class IV dendritic arborizing neurons of third instar larvae expressing pumHMS01685 under the control of Scer\GAL4477 is suppressed by combination wth a single copy of hidA206.

The dendritic arborization defects observed in class IV dendritic arborizing neurons of nos18/nos53 third instar larvae are suppresed by combination with hidA206.

ninaEP37H, ninaE17, Whid-A206/+ flies exhibit strong recovery of visual response to light stimulation.

A Whid-A206 heterozygous background suppresses the degree of rprUTR.Scer\UAS.T:Ivir\HA1-indued eye ablation.

The small wing and eye phenotypes caused by hpoScer\UAS.cUa overexpression, (through Scer\GAL4unspecified or Scer\GAL4C5) can be partially suppressed by heterozygosity for Whid-A206, indicating that hpo requires W for its action.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Mutant males can be ranked based on the severity of terminalia rotation: Df(3L)H99 > Whid-H109 > Whid-A22 > Whid-A206 > Whid-A329 > Whid-H89. The ranking is roughly similar to the one for the degree to which the alleles disrupt embryonic head development.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
References (10)