FlyBase Allele Report: Dmel\Ras85D[N17.sev]

General Information

Symbol

Dmel\Ras85D^N17.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0048926

Feature type

allele

Associated gene

Dmel\Ras85D

Associated Insertion(s)

Carried in Construct

P{sevRas1.N17}

Also Known As

sev-Ras1^N17, sev-Ras^N17

Key Links

Transgenic product class

dominant_negative_variant

(Karim et al., 1996)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

dominant_negative_variant

(Karim et al., 1996)

Mutagen

in vitro construct

(Karim et al., 1996)

Progenitor genotype

Carried in construct

P{sevRas1.N17}

Cytology

Description

Allele components

Component

Use(s)

Encoded product / tool

Ras85D

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Rendina et al., 2010, Bai et al., 2001, Firth et al., 2000, Rebay et al., 2000, Taguchi et al., 2000, Ruden et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

Ras85D^N17.sev flies have a weak rough eye phenotype and lack many photoreceptor R7 cells.

(Rendina et al., 2010)

Ras85D^N17.sev mutant eyes exhibit a rough eye phenotype.

(Wang et al., 2008)

Rough eye phenotype.

(Bai et al., 2001)

Flies carrying Ras85D^V12.sev have a mild rough eye phenotype and show loss of R7 cells.

(Firth et al., 2000)

Flies carrying Ras85D^N17.sev have a rough eye phenotype caused by the absence of the R7 cell in approximately 25% of ommatidia and a lack of outer photoreceptor cells.

(Taguchi et al., 2000)

Mutants exhibit a loss of R7 cells (0.757 per ommatidium, compared to 1.0 in wild-type).

(Zhang and Lu, 2000)

Halving the cno⁺ dose enhances the effect of Ras85D^N17.sev resulting in a further decrease in the number of cone cells.

(Matsuo et al., 1997)

Rough eye phenotype complementary to that of Ras85D^V12.sev : approximately 25% of the ommatidia are missing the R7 cell and occasionally an ommatidium lacks an outer photoreceptor cell.

(Karim et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ras85D^N17.sev has visible phenotype, enhanceable by csw^lf

(Firth et al., 2000)

Ras85D^N17.sev has visible phenotype, enhanceable by EM3-1^EM3-1

(Taguchi et al., 2000)

Ras85D^N17.sev has visible phenotype, enhanceable by S^EM2-4

(Taguchi et al., 2000)

Ras85D^N17.sev has visible phenotype, enhanceable by S^EF2-1

(Taguchi et al., 2000)

Ras85D^N17.sev has visible phenotype, enhanceable by S^Kojak

(Ruden et al., 1999)

Suppressed by

Statement

Reference

Ras85D^N17.sev has visible phenotype, suppressible by Bap170^hfl1

(Rendina et al., 2010)

Ras85D^N17.sev has visible phenotype, suppressible by ed[+]/ed^1X5

(Bai et al., 2001)

Ras85D^N17.sev has visible phenotype, suppressible by SM2-1^SM2-1

(Taguchi et al., 2000)

Ras85D^N17.sev has visible phenotype, suppressible by SM3-2^SM3-2

(Taguchi et al., 2000)

Ras85D^N17.sev has visible phenotype, suppressible by SM3-3^SM3-3

(Taguchi et al., 2000)

Ras85D^N17.sev has visible phenotype, suppressible by SM3-6^SM3-6

(Taguchi et al., 2000)

Ras85D^N17.sev has visible phenotype, suppressible by SM3-8^SM3-8

(Taguchi et al., 2000)

Ras85D^N17.sev has visible phenotype, suppressible by bul^SF3-1

(Taguchi et al., 2000)

Ras85D^N17.sev has visible phenotype, suppressible by cln^SF3-2

(Taguchi et al., 2000)

Ras85D^N17.sev has visible phenotype, suppressible by cln^SF3-3

(Taguchi et al., 2000)

NOT Enhancer of

Statement

Reference

Ras85D^N17.sev is a non-enhancer of abnormal cell death phenotype of rpr^GMR.PW

(Bergmann et al., 1998)

Ras85D^N17.sev is a non-enhancer of abnormal cell death phenotype of grim^GMR.PC

(Bergmann et al., 1998)

NOT Suppressor of

Statement

Reference

Ras85D^N17.sev is a non-suppressor of abnormal cell death phenotype of grim^GMR.PC

(Bergmann et al., 1998)

Ras85D^N17.sev is a non-suppressor of abnormal cell death phenotype of rpr^GMR.PW

(Bergmann et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ras85D^N17.sev has ommatidium phenotype, enhanceable by csw^lf

(Firth et al., 2000)

Ras85D^N17.sev has photoreceptor cell R7 phenotype, enhanceable by csw^lf

(Firth et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by eya^G130

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by eya^A188

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by rl^A0648

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by Sos^D120

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by Sos^xB10

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by S^BA651

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by S^U132

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by EY2-5^AH425

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by EY2-6^AQR618

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by EY2-6^AC403

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by spen^AH393

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by spen^BU720

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by EY2-8^EP1160

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by pnt^AP553

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by pnt^AF397

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by EY3-4^xII790

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by EY3-4^x1S805

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by EY3-5^xZB970

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by EY3-5^xKR845

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by EM3-1^EM3-1

(Taguchi et al., 2000)

Ras85D^N17.sev has ommatidium phenotype, enhanceable by EM3-1^EM3-1

(Taguchi et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by S^EM2-4

(Taguchi et al., 2000)

Ras85D^N17.sev has ommatidium phenotype, enhanceable by S^EM2-4

(Taguchi et al., 2000)

Ras85D^N17.sev has ommatidium phenotype, enhanceable by S^EF2-1

(Taguchi et al., 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by S^EF2-1

(Taguchi et al., 2000)

Ras85D^N17.sev has photoreceptor cell R7 phenotype, enhanceable by cnk^sag13L/sag[+]

(Zhang and Lu, 2000)

Ras85D^N17.sev has eye phenotype, enhanceable by S^Kojak

(Ruden et al., 1999)

Ras85D^N17.sev has photoreceptor cell R7 phenotype, enhanceable by S^Kojak

(Ruden et al., 1999)

NOT Enhanced by

Statement

Reference

Ras85D^N17.sev has phenotype, non-enhanceable by lilli^XS407

(Tang et al., 2001)

Ras85D^N17.sev has phenotype, non-enhanceable by lilli^XS575

(Tang et al., 2001)

Ras85D^N17.sev has phenotype, non-enhanceable by lilli^s35

(Tang et al., 2001)

Ras85D^N17.sev has phenotype, non-enhanceable by Su(Tpl)^DI998

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by Su(Tpl)^EZ1217

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by lilli^DE884

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by Sin3A^CY886

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by Sin3A^DW1046

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by Taf4^AG456

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by Taf4^I53

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by retn^B142

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by retn^x1N793

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by gl^DZ1053

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by gl^ER1085

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by stg^D115

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by stg^DD937

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by EY2-5^DW1080

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by EY2-8^xCB204

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by EY3-2^xAZ145

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by EY3-2^xCF301

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by EY3-2^xDF411

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by EY3-3^xBE183

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by EY3-3^xF6

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by sty^SM3-5

(Taguchi et al., 2000)

Ras85D^N17.sev has phenotype, non-enhanceable by sty^SM3-9

(Taguchi et al., 2000)

Suppressed by

Statement

Reference

Ras85D^N17.sev has eye phenotype, suppressible by Bap170^hfl1

(Rendina et al., 2010)

Ras85D^N17.sev has photoreceptor cell R7 phenotype, suppressible by Bap170^hfl1

(Rendina et al., 2010)

Ras85D^N17.sev has eye phenotype, suppressible by Cbl^K26

(Wang et al., 2008)

Ras85D^N17.sev has eye phenotype, suppressible by ed[+]/ed^1X5

(Bai et al., 2001)

Ras85D^N17.sev has eye phenotype, suppressible by lilli^DR999

(Rebay et al., 2000)

Ras85D^N17.sev has eye phenotype, suppressible by SM2-1^SM2-1

(Taguchi et al., 2000)

Ras85D^N17.sev has ommatidium phenotype, suppressible by SM2-1^SM2-1

(Taguchi et al., 2000)

Ras85D^N17.sev has eye phenotype, suppressible by SM3-2^SM3-2

(Taguchi et al., 2000)

Ras85D^N17.sev has ommatidium phenotype, suppressible by SM3-2^SM3-2

(Taguchi et al., 2000)

Ras85D^N17.sev has eye phenotype, suppressible by SM3-3^SM3-3

(Taguchi et al., 2000)

Ras85D^N17.sev has ommatidium phenotype, suppressible by SM3-3^SM3-3

(Taguchi et al., 2000)

Ras85D^N17.sev has eye phenotype, suppressible by SM3-6^SM3-6

(Taguchi et al., 2000)

Ras85D^N17.sev has ommatidium phenotype, suppressible by SM3-6^SM3-6

(Taguchi et al., 2000)

Ras85D^N17.sev has eye phenotype, suppressible by SM3-8^SM3-8

(Taguchi et al., 2000)

Ras85D^N17.sev has ommatidium phenotype, suppressible by SM3-8^SM3-8

(Taguchi et al., 2000)

Ras85D^N17.sev has eye phenotype, suppressible by bul^SF3-1

(Taguchi et al., 2000)

Ras85D^N17.sev has ommatidium phenotype, suppressible by bul^SF3-1

(Taguchi et al., 2000)

Ras85D^N17.sev has eye phenotype, suppressible by cln^SF3-2

(Taguchi et al., 2000)

Ras85D^N17.sev has ommatidium phenotype, suppressible by cln^SF3-2

(Taguchi et al., 2000)

Ras85D^N17.sev has eye phenotype, suppressible by cln^SF3-3

(Taguchi et al., 2000)

Ras85D^N17.sev has ommatidium phenotype, suppressible by cln^SF3-3

(Taguchi et al., 2000)

Ras85D^N17.sev has phenotype, suppressible by aop^E-867

(Karim et al., 1996)

Ras85D^N17.sev has phenotype, suppressible by aop^yan-XE18

(Karim et al., 1996)

NOT suppressed by

Statement

Reference

Ras85D^N17.sev has phenotype, non-suppressible by lilli^XS407

(Tang et al., 2001)

Ras85D^N17.sev has phenotype, non-suppressible by lilli^s35

(Tang et al., 2001)

Ras85D^N17.sev has phenotype, non-suppressible by lilli^XS575

(Tang et al., 2001)

Ras85D^N17.sev has phenotype, non-suppressible by EY2-5^DW1080

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by EY2-8^xCB204

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by Sin3A^CY886

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by Sin3A^DW1046

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by Taf4^AG456

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by Taf4^I53

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by retn^B142

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by retn^x1N793

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by gl^DZ1053

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by gl^ER1085

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by stg^D115

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by stg^DD937

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by EY3-2^xAZ145

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by EY3-2^xCF301

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by EY3-2^xDF411

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by EY3-3^xBE183

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by EY3-3^xF6

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by Su(Tpl)^DI998

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by Su(Tpl)^EZ1217

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by lilli^DE884

(Rebay et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by sty^SM3-5

(Taguchi et al., 2000)

Ras85D^N17.sev has phenotype, non-suppressible by sty^SM3-9

(Taguchi et al., 2000)

Enhancer of

Statement

Reference

Ras85D^N17.sev is an enhancer of eye phenotype of hid^GMR.PG

(Bergmann et al., 1998)

Ras85D^N17.sev is an enhancer of ommatidium phenotype of hid^GMR.PG

(Bergmann et al., 1998)

NOT Enhancer of

Statement

Reference

Ras85D^N17.sev is a non-enhancer of eye phenotype of rpr^GMR.PW

(Bergmann et al., 1998)

Ras85D^N17.sev is a non-enhancer of eye phenotype of grim^GMR.PC

(Bergmann et al., 1998)

NOT Suppressor of

Statement

Reference

Ras85D^N17.sev is a non-suppressor of eye phenotype of grim^GMR.PC

(Bergmann et al., 1998)

Ras85D^N17.sev is a non-suppressor of eye phenotype of rpr^GMR.PW

(Bergmann et al., 1998)

Other

Statement

Reference

Ras85D^N17.sev, rl^AL528 has eye phenotype

(Rebay et al., 2000)

Ras85D^N17.sev, S^IIN has photoreceptor cell R7 phenotype

(Ruden et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Bap170^hfl1 completely suppresses the rough eye phenotype and loss of photoreceptor R7 cells caused by Ras85D^N17.sev.

(Rendina et al., 2010)

A Cbl^K26 heterozygous background moderately strongly suppresses the rough eye phenotype found in Ras85D^N17.sev mutants.

(Wang et al., 2008)

The rough eye phenotype and loss of R7 cells produced by Ras85D^N17.sev is enhanced by csw^lf/Y.

(Firth et al., 2000)

The addition of sag^13L/+ dominantly enhances the loss of R7 phenotype seen in Ras85D^N17.sev flies, almost halving the average number of R7-like cells seen per ommatidium (from 0.757 to 0.415).

(Zhang and Lu, 2000)

The small eye phenotype of flies carrying Ras85D^N17.sev is enhanced by S^Kojak. Ras85D^N17.sev/S^Kojak flies have as many as 3 to 4 extra R7 photoreceptor cells in each ommatidium. Flies doubly mutant for S^IIN and Ras85D^N17.sev have no R7 photoreceptor cells.

(Ruden et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Ras85D^N17.sev rescues Ras85D^R68Q

(Gafuik and Steller, 2011)

Comments

Ras85D^N17.sev expression in the eye abrogates the suppressive effects of Ras85D^R68Q on W^GMR.PG-induced apoptosis.

(Gafuik and Steller, 2011)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Dominant negative form.

(Matsuo et al., 1997)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ras85D^N17.sev

Ras^DN

(Ruden et al., 1999)

Ras^N17

(Rebay et al., 2000)

sev-Ras1^N17

(Zhang and Lu, 2000, Matsuo et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (14)

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