FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\sggA81T.UAS
Open Close
General Information
Symbol
Dmel\sggA81T.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0097906
Feature type
allele
Associated gene
Dmel\sgg
Associated Insertion(s)
Carried in Construct
P{UAS-sgg.A81T}
Also Known As
UAS-sggDN, sggA81T, UAS-SGG.A81T, UAS-sggDN, UAS-SggA81T, UAS-Sgg-DN
Key Links
Transgenic product class
missense_variant
(Bourouis, 1999.6.7)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Bourouis, 1999.6.7)
Mutagen
in vitro construct
(Bourouis, 1999.6.7)
Progenitor genotype
Carried in construct
P{UAS-sgg.A81T}
Cytology
Description

Expression of an inactive form of the sgg gene product (carries the amino acid replacement A81T) is governed by UAS regulatory sequences.

(Bourouis, 1999.6.7)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
sgg
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Hsap\LRRK2G2019S.UAS.cLa.Tag:FLAG
      (Lin et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of sggA81T.UAS under the control of Scer\GAL4nub-AC-62 induces ectopic wing blade bristles.

      (Marcetteau et al., 2021)

      Expression of sggA81T.UAS under the control of Scer\GAL4Appl.G1a leads to axonal blockages in third instar larval segmental nerves compared to controls.

      (Banerjee et al., 2018)

      The expression of sggA81T.UAS under the control of Scer\GAL4salm.E leads to notched wings and to truncated longitudinal veins, as compared to controls.

      (Zeng et al., 2018)

      Adult flies expressing sggA81T.Scer\UAS driven by Scer\GAL4esg-NP7397 combined with tub-Gal80[ts] (for temporal control) display increase in midgut stem cell proliferation (assessed by number of pH3-positive cells).

      (Perea et al., 2017)

      Expression of dominant negative sggA81T.Scer\UAS under the control of Scer\GAL4BG380 suppresses the Liprin-αR60/Liprin-αF3ex15 mutant distal axon phenotype.

      (Li et al., 2014)

      Expression of sggA81T.Scer\UAS under the control of Scer\GAL4elav-C155 results in an increase in average satellite bouton number at the larval neuromuscular junction.

      (Rodal et al., 2011)

      Expression of Scer\GAL4109(2)80>sggA81T.Scer\UAS causes significant dendritic defects compared with controls.

      (Lin et al., 2010)

      Expression of sggA81T.Scer\UAS with Scer\GAL4C380 does not interfere with ghost bouton formation upon 5X K[+] spaced depolarisation, although this increase is slightly less robust than wildtype controls. The number of ghost boutons is significantly increased upon just three cycles of stimulation, compared to controls which require four or five cycles of stimulation. Potentiation of mEJP (spontaneous excitatory potentials) frequency was augmented by almost 4-fold upon presynaptic expression of sggA81T.Scer\UAS.

      (Ataman et al., 2008)

      Pan-neural expression of the dominant-negative sggA81T.Scer\UAS transgene under the control of Scer\GAL4elav-C155 produces expanded synapses that are 127% the size of control synapses.

      Expression of the dominant-negative sggA81T.Scer\UAS transgene in differentiated post-mitotic neurons under the control of Scer\GAL4elav-C155 reduces transmitter release.

      Expression of sggA81T.Scer\UAS under the control of Scer\GAL4OK6 severely and significantly reduces EJC amplitude compared to controls.

      (Franciscovich et al., 2008)

      Overexpression of sggA81T.Scer\UAS in clock cells under the control of Scer\GAL4tim.PE results in a shortening of circadian period.

      Overexpression of sggA81T.Scer\UAS in post-mitotic neurons under the control of Scer\GAL4elav-C155 has no effect on olfactory habituation.

      (Wolf et al., 2007)

      There is an increase in the number of synaptic boutons at the neuromuscular junction in larvae expressing sggA81T.Scer\UAS under the control of Scer\GAL4elav.PU.

      (Gogel et al., 2006)

      Unlike overexpression of wild-type sgg, expression of sggA81T.Scer\UAS, driven by Scer\GAL4sca-P309, does not affect macrochaete formation.

      (Kanuka et al., 2005)

      Overexpression of sggA81T.Scer\UAS under the control of Scer\GAL4tim.PE does not shorten the period of circadian rhythm in the flies in free-running conditions.

      (Yuan et al., 2005)

      Expression of sggA81T.Scer\UAS presynaptically, under the control of either Scer\GAL4BG380, Scer\GAL4elav-C155 or Scer\GAL4OK6, at larval neuromuscular junctions results in a 50-100% increase in the number of synaptic boutons. There is also an increase in the number of "satellite" boutons, defined as boutons that are present in the axon of a branch or that bud off from neuronal connections between two boutons. These NMJs show a concomitant increase in the number of microtubule loops, with many loops localized in satellite boutons. In contrast, expression of sggA81T.Scer\UAS postsynaptically, driven by Scer\GAL4Mhc.PW, does not affect bouton or microtubule loop number.

      (Franco et al., 2004)

      Expression of sggA81T.Scer\UAS under the control of Scer\GAL4455.2 rarely results in the loss of scutellar bristles. Expression of sggA81T.Scer\UAS under the control of Scer\GAL4sca-537.4 has no effect on the wing margin.

      (Bourouis, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      NOT Enhanced by
      Suppressed by
      Enhancer of
      Suppressor of
      Other
      Phenotype Manifest In
      NOT Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4VGlut1-OK371, sggA81T.UAS has mechanosensory neuron of leg campaniform sensillum | decreased number phenotype, suppressible by Cul1NIG.1877R, Scer\GAL4VGlut1-OK371

      (Lee et al., 2024)

      Scer\GAL4VGlut1-OK371, sggA81T.UAS has axon | adult stage phenotype, suppressible by Cul1NIG.1877R, Scer\GAL4VGlut1-OK371

      (Lee et al., 2024)

      Scer\GAL4hs.PB, sggA81T.UAS has adult hemolymph phenotype, suppressible by Cul1NIG.1877R, Scer\GAL4hs.PB

      (Lee et al., 2024)

      Scer\GAL4VGlut1-OK371, sggA81T.UAS has mechanosensory neuron of leg campaniform sensillum | decreased number phenotype, suppressible by UchUAS.cLa/Scer\GAL4VGlut1-OK371

      (Lee et al., 2024)

      Scer\GAL4VGlut1-OK371, sggA81T.UAS has axon | adult stage phenotype, suppressible by UchUAS.cLa/Scer\GAL4VGlut1-OK371

      (Lee et al., 2024)

      Scer\GAL4hs.PB, sggA81T.UAS has adult hemolymph phenotype, suppressible by UchUAS.cLa/Scer\GAL4hs.PB

      (Lee et al., 2024)

      Scer\GAL4nub-AC-62, sggA81T.UAS has wing hair | ectopic phenotype, suppressible | partially by Arf61/Arf51F[+]

      (Marcetteau et al., 2021)

      Scer\GAL4salm.E, sggA81T.UAS has wing phenotype, suppressible by Nulp1PA.UAS, Scer\GAL4salm.E

      (Zeng et al., 2018)

      Scer\GAL4salm.E, sggA81T.UAS has wing vein phenotype, suppressible | partially by Nulp1PA.UAS, Scer\GAL4salm.E

      (Zeng et al., 2018)

      Scer\GAL4NP7397, sggA81T.UAS has intestinal stem cell of posterior adult midgut epithelium phenotype, suppressible by RetGD45, Scer\GAL4NP7397

      (Perea et al., 2017)

      Scer\GAL4elav-C155, sggA81T.UAS has synapse phenotype, suppressible by wnd[+]/wnd1

      (Franciscovich et al., 2008)

      Scer\GAL4elav-C155, sggA81T.UAS has synapse phenotype, suppressible by wnd[+]/wnd2

      (Franciscovich et al., 2008)

      Scer\GAL4elav-C155, sggA81T.UAS has synapse phenotype, suppressible by Scer\GAL4elav-C155/bskK53R.UAS

      (Franciscovich et al., 2008)

      Scer\GAL4RapGAP1-OK6, sggA81T.UAS has bouton | increased number phenotype, suppressible by futschK68

      (Franco et al., 2004)

      Scer\GAL4RapGAP1-OK6, sggA81T.UAS has bouton | increased number phenotype, suppressible by futschN94

      (Franco et al., 2004)
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4RapGAP1-OK6/sggA81T.UAS is a non-suppressor of bouton phenotype of futschN94

      (Franco et al., 2004)

      Scer\GAL4RapGAP1-OK6/sggA81T.UAS is a non-suppressor of bouton phenotype of futschK68

      (Franco et al., 2004)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of Nulp1PA.UAS greatly suppresses the notched wings and the truncated longitudinal veins (except for some defects in L4) induced by the expression of expression of Nulp1PA.UAS under the control of Scer\GAL4salm.E.

      (Zeng et al., 2018)

      The increased number of intestinal progenitor cells in mitosis characteristic for adult flies expressing sggA81T.Scer\UAS driven by Scer\GAL4esg-NP7397 (combined with tub-Gal80[ts] for temporal control) is suppressed by co-expression of RetGD45.

      (Perea et al., 2017)

      Co-expression of sggA81T.Scer\UAS and MadScer\UAS.cNa under the control of Scer\GAL4sca-537.4 results in wings with ectopic sensilla on a slightly thickened L3 vein and ectopic mechanosensory bristles on the dorsal margin.

      (Quijano et al., 2011)

      Co-expression of sggA81T.Scer\UAS and kayFbz.Scer\UAS in post-mitotic neurons under the control of Scer\GAL4elav-C155 significantly reduces EJC amplitude, beyond either transgene alone.

      A wnd1/+ background completely abolishes the synapse growth seen through sggA81T.Scer\UAS expression pan-neuronally under the control of Scer\GAL4elav-C155.

      A wnd2/+ background completely abolishes the synapse growth seen through sggA81T.Scer\UAS expression pan-neuronally under the control of Scer\GAL4elav-C155.

      Co-expression of bskK53R.Scer\UAS and sggA81T.Scer\UAS pan-neuronally under the control of Scer\GAL4elav-C155 severely and significantly reduces synapse size compared to synapses in Scer\GAL4elav-C155-sggA81T.Scer\UAS flies.

      Co-expression of kayScer\UAS.cEa and sggA81T.Scer\UAS pan-neurally under the control of Scer\GAL4elav-C155 strongly reduces EJC amplitude.

      (Franciscovich et al., 2008)

      Co-expression of 5-HT1BScer\UAS.cYa with sggA81T.Scer\UAS, both under the control of Scer\GAL4tim.PE in free-running conditions, fails to have a period-lengthening effect on the fly circadian rhythm.

      (Yuan et al., 2005)

      Expression of sggA81T.Scer\UAS under the control of Scer\GAL4OK6, in a futschK68 background shows the futschK68 phenotype in which larval neuromuscular synaptic bouton number is decreased and not the opposite sggA81T.Scer\UAS overexpression phenotype.

      Expression of sggA81T.Scer\UAS under the control of Scer\GAL4OK6, in a futschN94 background suppresses the increased larval neuromuscular bouton number phenotype, seen when sggA81T.Scer\UAS is expressed in a wild-type background. The phenotype is nearer to that seen in futschN94 single mutants, although the bouton number is not decreased as much.

      (Franco et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference

      The dendritic defects caused by Scer\GAL4109(2)80>sggA81T.Scer\UAS-expression are not enhanced by the co-expression of Hsap\LRRK2G2019S.Scer\UAS.cLa.T:Zzzz\FLAG.

      sggA81T.Scer\UAS suppresses the toxic effects of Scer\GAL4ppk.PG>Hsap\LRRK2G2019S.Scer\UAS.cLa.T:Zzzz\FLAG on microtubule fragmentation in dendritic processes.

      Co-expression of sggA81T.Scer\UAS restores dendritic patterns caused by Scer\GAL4Ddc.PL>Hsap\LRRK2G2019S.Scer\UAS.cLa.T:Zzzz\FLAG. In addition, sggA81T.Scer\UAS suppresses the life-span and locomotion defects caused by Scer\GAL4Ddc.PL>Hsap\LRRK2G2019S.Scer\UAS.cLa.T:Zzzz\FLAG.

      (Lin et al., 2010)

      Expression of sggA81T.Scer\UAS mitigates the Hsap\MAPTScer\UAS.cWa-induced bristle loss phenotype (with both under the control of Scer\GAL4Eq1).

      (Yeh et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      SGGDN
      (Banerjee et al., 2018)
      sggA81T.Scer\UAS
      sggA81T.UAS
      sggA81T
      (Rodal et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (25)