FB2026_02 , released June 18, 2026
Allele: Dmel\ebi2g2
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General Information
Symbol
Dmel\ebi2g2
Species
D. melanogaster
Name
FlyBase ID
FBal0191945
Feature type
allele
Associated gene
Dmel\ebi
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Coelho et al., 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: H533L.

(Marygold et al., 2011)

Nucleotide substitution: A?T.

(Marygold et al., 2011)

The CAC codon encoding H533 in the 5th WD repeat is changed to CTC.

(Marygold et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:417,129..417,129 [+]
Nucleotide change:

A417129T

Reported nucleotide change:

A?T

Amino acid change:

H533L | ebi-PA

Reported amino acid change:

H533L

Comment:

CAC to CTC mutation in codon 533.

(Marygold et al., 2011)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The wing pouch of ebiP7/ebi2g2 larval wing discs is reduced to about a quarter of its normal size.

      No or very few ebi2g2 clones survive to late third instar stage when induced at 48 hours after egg deposition (AED), and survival is not improved by inducing clones in a Minute/+ background. Clones induced at 72 hours AED do survive, but are very small.

      (Marygold et al., 2011)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      E-2g[+]/ebi2g2 is an enhancer of abnormal size phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

      (Marygold et al., 2011)

      E-2g[+]/ebi2g2 is an enhancer of visible phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

      (Coelho et al., 2005)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      E-2g[+]/ebi2g2 is an enhancer of wing phenotype of Pi3K92ED954A.UAS.Tag:MYC, Scer\GAL4Bx-MS1096

      (Marygold et al., 2011, Coelho et al., 2005)

      E-2g[+]/ebi2g2 is an enhancer of wing margin phenotype of sdETX4

      (Marygold et al., 2011)
      Other
      Statement
      Reference

      ebi2g2, vg1 has wing vein phenotype

      (Marygold et al., 2011)

      ebi2g2, vg1 has wing margin phenotype

      (Marygold et al., 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for ebi2g2 enhances the small wing phenotype induced by Scer\GAL4Bx-MS1096-mediated expression of Pi3K92ED954A.Scer\UAS.T:Hsap\MYC.

      Heterozygosity for ebi2g2 enhances the small wing and wing vein loss phenotypes induced by Scer\GAL4Bx-MS1096-mediated expression of aosScer\UAS.cMa.

      Flies heterozygous for both vg1 and ebi2g2 display wing notching and wing venation phenotypes that are not observed in any single heterozygote.

      Heterozygosity for ebi2g2 enhances the notched wing margin phenotype seen in sdETX4 hemizygous males.

      (Marygold et al., 2011)

      E-2g2 dominantly enhances the small wing and wing vein loss phenotypes caused by expression of argosScer\UAS.cMa under the control of Scer\GAL4Bx-MS1096.

      (Coelho et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a dominant modifier of the small wing phenotype caused by expression of Pi3K92ED954A.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Bx-MS1096. Induced with: dp2f1-olv.

      (Coelho et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      E-2f1
      (Coelho et al., 2005)
      E-2g2
      (Marygold et al., 2011)
      ebi2g2
      (Marygold et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)