FlyBase Allele Report: Dmel\Sod1[UAS.cAa]

General Information

Symbol

Dmel\Sod1^UAS.cAa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Anderson

FlyBase ID

FBal0198445

Feature type

allele

Associated gene

Dmel\Sod1

Associated Insertion(s)

Carried in Construct

P{UAS-Sod1.A}

Also Known As

UAS-Sod1, UAS-Sod.A, P{UAS-Sod.A}, UAS-Sod, UAS-dSOD1

Key Links

Transgenic product class

cDNA

(Anderson et al., 2005)

wild_type

(Anderson et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Anderson et al., 2005)

wild_type

(Anderson et al., 2005)

Mutagen

in vitro construct

(Anderson et al., 2005)

Progenitor genotype

Carried in construct

P{UAS-Sod1.A}

Cytology

Description

UASt regulatory sequences drive expression of a Sod1 cDNA.

(Anderson et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Sod1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

DOES NOT ameliorate Parkinson's disease

modeled by Chchd2^null

(Meng et al., 2017)

ameliorates epilepsy

modeled by pk^sple-1

(Nukala et al., 2023)

exacerbates neurodegenerative disease

modeled by Zzzz\CAG^{Q48.UAS.Tag:MYC,Tag:FLAG}

(Underwood et al., 2010)

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Rival et al., 2009)

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}

(Rival et al., 2009)

exacerbates mucopolysaccharidosis type IIIA

modeled by Sgsh^GD1578

(Webber et al., 2018)

ameliorates cancer

modeled by Ras85D^Q13.UAS

(Tamamouna et al., 2021)

modeled by Ras85D^V12.UAS, scrib⁶⁷³

(Pérez et al., 2017)

exacerbates amyotrophic lateral sclerosis type 8

modeled by Vap33^Δ166, Vap33^P58S.cRa.UAS

(Tendulkar et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | larval stage, with Scer\GAL4^GMR11F02

(Li et al., 2024)

abnormal stress response | adult stage, with Scer\GAL4^rn-GAL4-5

(Khan et al., 2017)

visible | adult stage, with Scer\GAL4^rn-GAL4-5

(Khan et al., 2017)

Phenotype Manifest In

wing, with Scer\GAL4^rn-GAL4-5

(Khan et al., 2017)

wing disc | third instar larval stage, with Scer\GAL4^rn-GAL4-5

(Khan et al., 2017)

Detailed Description

Statement

Reference

Adults expressing Sod1^UAS.cAa under the control of Scer\GAL4^elav.PLu do not exhibit climbing defects compared to controls.

(Webber et al., 2018)

The size distribution of regenerated adult wings in flies expressing Sod1^Scer\UAS.cAa under the control of Scer\GAL4^rn-GAL4-5 that were subjected to ablation of imaginal wing disc tissue during the larval stage, is significantly shifted towards smaller wing size compared to similarly treated wild-type controls. The regeneration appears to proceed more slowly in the Sod1^Scer\UAS.cAa-expressing larvae as assessed by size of the regenerating wing pouch over time and the larvae also fail to delay entry into pupariation for as long as the control regenerating larvae. Without any tissue damage the timing of pupariation in Sod1^Scer\UAS.cAa-expressing animals is not significantly different from the wild-type.

(Khan et al., 2017)

The expression of Sod1^Scer\UAS.cAa under the control of Scer\GAL4^da.PU does not significantly affect the adult life-span, the adult locomotor capacity in negative geotaxis assays, or the numbers of dopaminergic PAL, PPM1/2, PPM3, PPL1 and PPL2 neurons in the adult brain, as compared to controls.

(Meng et al., 2017)

Expression of Sod1^Scer\UAS.cAa under the control of Scer\GAL4^da.PU suppresses the age-dependent loss of rhabdomeres and partially suppresses the age-dependent locomotor defect seen in YME1L^del homozygotes.

Expression of Sod1^Scer\UAS.cAa under the control of Scer\GAL4^da.PU extends the lifespan of YME1L^del homozygotes.

(Qi et al., 2016)

Expression via Scer\GAL4^wor.PA and Scer\GAL80^ase.PN has no effect on pupal neuroblast size or number.

(Homem et al., 2014)

Flies expressing Sod^Scer\UAS.cAa under the control of Scer\GAL4^{Hand.ΔVM.Switch} show no significant difference in heart function compared to controls.

(Monnier et al., 2012)

Lifespan patterns of Sod^Scer\UAS.cAa overexpression using Scer\GAL4^da.G32 are not significantly different from diet-matched controls, suggesting that Sod^Scer\UAS.cAa overexpression if not sufficient to alter the lifespan response of flies to diet.

(Sun et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Sod1^UAS.cAa/Scer\GAL4^elav.PLu is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Scer\GAL4^elav.PLu, Sgsh^GD1578

(Webber et al., 2018)

Sod1^UAS.cAa/Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{Q48.UAS.Tag:MYC,Tag:FLAG}

(Underwood et al., 2010)

Sod1^UAS.cAa, Scer\GAL4^elav-C155 is an enhancer of abnormal locomotor behavior phenotype of Hsap\APP^{Aβ42.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Rival et al., 2009)

Sod1^UAS.cAa, Scer\GAL4^elav-C155 is an enhancer of short lived phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Rival et al., 2009)

Sod1^UAS.cAa, Scer\GAL4^elav-C155 is an enhancer of abnormal locomotor behavior phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Rival et al., 2009)

Suppressor of

Statement

Reference

Sod1^UAS.cAa, Scer\GAL4^nub.PU is a suppressor of visible | adult stage phenotype of Gp93^NIG.5520R, Scer\GAL4^nub.PU

(Xu et al., 2025)

Sod1^UAS.cAa, Scer\GAL4^nub.PU is a suppressor of increased cell death | larval stage phenotype of Gp93^NIG.5520R, Scer\GAL4^nub.PU

(Xu et al., 2025)

Sod1^UAS.cAa, Scer\GAL4^nub.PU is a suppressor of decreased size | adult stage phenotype of Gp93^NIG.5520R, Scer\GAL4^nub.PU

(Xu et al., 2025)

Sod1^UAS.cAa/Scer\GAL4^ple.PF is a suppressor of decreased rate of jump response phenotype of Pink1^B9

(Xia et al., 2024)

Sod1^UAS.cAa/Scer\GAL4^ple.PF is a suppressor | partially of abnormal neuroanatomy | adult stage phenotype of Pink1^B9

(Xia et al., 2024)

Sod1^UAS.cAa/Scer\GAL4^arm.PS is a suppressor of decreased rate of adult locomotory behavior phenotype of Creld^Δ51

(Paradis et al., 2022)

Sod1^UAS.cAa/Scer\GAL4^ple.PF is a suppressor of decreased rate of adult locomotory behavior phenotype of Creld^Δ51

(Paradis et al., 2022)

Sod1^UAS.cAa/Scer\GAL4^NP2222 is a suppressor | partially of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

Sod1^UAS.cAa, Scer\GAL4^Tub.PU is a suppressor | partially of short lived phenotype of Adck1^NIG.3608R, Scer\GAL4^Tub.PU

(Yoon et al., 2019)

Sod1^UAS.cAa/Scer\GAL4^da.PU is a suppressor of abnormal neuroanatomy | progressive phenotype of YME1L^del

(Qi et al., 2016)

Sod1^UAS.cAa/Scer\GAL4^da.PU is a suppressor | partially of abnormal locomotor behavior | progressive phenotype of YME1L^del

(Qi et al., 2016)

Sod1^UAS.cAa/Scer\GAL4^da.PU is a suppressor of short lived phenotype of YME1L^del

(Qi et al., 2016)

Sod1^UAS.cAa, Scer\GAL4^GMR.PF is a suppressor | partially of visible phenotype of Cln3^UAS.cTa, Scer\GAL4^GMR.PF

(Tuxworth et al., 2011)

NOT Suppressor of

Statement

Reference

Sod1^UAS.cAa/Scer\GAL4^da.PU is a non-suppressor of abnormal locomotor behavior | adult stage | progressive phenotype of Chchd2^null

(Meng et al., 2017)

Sod1^UAS.cAa/Scer\GAL4^da.PU is a non-suppressor of short lived phenotype of Chchd2^null

(Meng et al., 2017)

Scer\GAL4^109(2)80/Sod1^UAS.cAa is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

Sod1^UAS.cAa/Scer\GAL4^ninaE.PT is a non-suppressor of abnormal neurophysiology | somatic clone | adult stage phenotype of fh¹

(Chen et al., 2016)

Sod1^UAS.cAa/Scer\GAL4^Mef2.PR is a non-suppressor of partially lethal - majority die phenotype of p38a¹, p38b^Δ25

(Vrailas-Mortimer et al., 2011)

Sod1^UAS.cAa/Scer\GAL4^da.G32 is a non-suppressor of lethal phenotype of Scer\GAL4^da.G32, fh^RNAi.UAS.cAa

(Anderson et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

Sod1^UAS.cAa/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{Q48.UAS.Tag:MYC,Tag:FLAG}

(Underwood et al., 2010)

Suppressor of

Statement

Reference

Sod1^UAS.cAa, Scer\GAL4^nub.PU is a suppressor of wing phenotype of Gp93^NIG.5520R, Scer\GAL4^nub.PU

(Xu et al., 2025)

Sod1^UAS.cAa, Scer\GAL4^nub.PU is a suppressor of wing disc | larval stage phenotype of Gp93^NIG.5520R, Scer\GAL4^nub.PU

(Xu et al., 2025)

Sod1^UAS.cAa/Scer\GAL4^Act5C.PI is a suppressor of NMJ bouton | increased number | larval stage phenotype of Alkbh8^1-IC

(Madhwani et al., 2024)

Sod1^UAS.cAa/Scer\GAL4^ple.PF is a suppressor | partially of adult dopaminergic neuron | decreased number phenotype of Pink1^B9

(Xia et al., 2024)

Sod1^UAS.cAa/Scer\GAL4^ple.PF is a suppressor | partially of adult brain phenotype of Pink1^B9

(Xia et al., 2024)

Sod1^UAS.cAa/Scer\GAL4^NP2222 is a suppressor | partially of neuroblast | larval stage phenotype of Scer\GAL4^NP2222, htl^λ.UAS

(Dong et al., 2021)

Sod1^UAS.cAa/Scer\GAL4^da.PU is a suppressor of rhabdomere | progressive phenotype of YME1L^del

(Qi et al., 2016)

Sod1^UAS.cAa, Scer\GAL4^tin.CΔ4 is a suppressor of adult heart phenotype of Marf^RNAi.UAS.cUa, Scer\GAL4^tin.CΔ4

(Dorn et al., 2011)

Sod1^UAS.cAa, Scer\GAL4^tin.CΔ4 is a suppressor | partially of mitochondrion | adult stage phenotype of Marf^RNAi.UAS.cUa, Scer\GAL4^tin.CΔ4

(Dorn et al., 2011)

Sod1^UAS.cAa, Scer\GAL4^tin.CΔ4 is a suppressor | partially of cardial cell | adult stage phenotype of Marf^RNAi.UAS.cUa, Scer\GAL4^tin.CΔ4

(Dorn et al., 2011)

Sod1^UAS.cAa, Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of Cln3^UAS.cTa, Scer\GAL4^GMR.PF

(Tuxworth et al., 2011)

NOT Suppressor of

Statement

Reference

Sod1^UAS.cAa/Scer\GAL4^da.PU is a non-suppressor of dopaminergic PPL1 neuron | adult stage phenotype of Chchd2^null

(Meng et al., 2017)

Scer\GAL4^109(2)80/Sod1^UAS.cAa is a non-suppressor of abdominal dorsal multidendritic neuron ddaC | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

Scer\GAL4^109(2)80/Sod1^UAS.cAa is a non-suppressor of dendrite | third instar larval stage phenotype of Scer\GAL4^109(2)80, prel^UAS.Tag:HA

(Tsuyama et al., 2017)

Sod1^UAS.cAa/Scer\GAL4^ninaE.PT is a non-suppressor of eye photoreceptor cell | somatic clone | adult stage phenotype of fh¹

(Chen et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of Sod1^Scer\UAS.cAa under the control of Scer\GAL4^da.PU does not suppress the decreased adult life-span, the adult locomotor defects or the decreased number of dopaminergic PPL1 neurons in the adult brain, displayed by Chchd2^null hemizygotes.

(Meng et al., 2017)

The shortening of the dendritic arbor in class IV ddaC neurons in third instar larvae expressing prel^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^109(2)80 is not significantly affected by co-expression of Sod1^Scer\UAS.cAa.

(Tsuyama et al., 2017)

Expression of Sod1^Scer\UAS.cAa under the control of Scer\GAL4^ninaE.PT fails to rescue the neurodegeneration and electrophysiology defect seen in fh¹ mutant photoreceptor clones.

(Chen et al., 2016)

Co-expression of Sod^Scer\UAS.cAa rescues the heart tube defects (dilation and impaired shortening) seen in adults expressing Marf^{miRNA.cUa.Scer\UAS} under the control of Scer\GAL4^tin.CΔ4. In addition, the morphology of the mitochondria in the cardiomyocytes is markedly improved towards wild type.

(Dorn et al., 2011)

Co-expression of Sod^Scer\UAS.cAa under the control of Scer\GAL4^GMR.PF almost completely suppresses the cln3^Scer\UAS.cTa-overexpression phenotype in the eye.

(Tuxworth et al., 2011)

Expression of Sod^Scer\UAS.cAa under the control of Scer\GAL4^Mef2.PR does not rescue the reduced viability seen in p38b^Δ25 Mpk2¹ double mutants.

(Vrailas-Mortimer et al., 2011)

Xenogenetic Interactions

Statement

Reference

Overexpression of Sod^Scer\UAS.cAa enhances the decreased survival phenotype of flies expressing Hsap\APP^{Arctic.Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

Overexpression of Sod^Scer\UAS.cAa accelerates the decline in locomotor function of flies expressing Hsap\APP^{Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

(Rival et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

24750

w¹; P{UAS-Sod1.A}B37

24754

w¹; P{UAS-Sod1.A}B36

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Sod1^Scer\UAS.cAa

Sod1^UAS.cAa

Sod^Scer\UAS.cAa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Anderson

Secondary FlyBase IDs

References (51)

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