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General Information
Symbol
Dmel\Sod1UAS.cAa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Anderson
FlyBase ID
FBal0198445
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Sod1, UAS-Sod.A, P{UAS-Sod.A}
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a Sod1 cDNA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Adults expressing Sod1UAS.cAa under the control of Scer\GAL4elav.PLu do not exhibit climbing defects compared to controls.

The size distribution of regenerated adult wings in flies expressing Sod1Scer\UAS.cAa under the control of Scer\GAL4rn-GAL4-5 that were subjected to ablation of imaginal wing disc tissue during the larval stage, is significantly shifted towards smaller wing size compared to similarly treated wild-type controls. The regeneration appears to proceed more slowly in the Sod1Scer\UAS.cAa-expressing larvae as assessed by size of the regenerating wing pouch over time and the larvae also fail to delay entry into pupariation for as long as the control regenerating larvae. Without any tissue damage the timing of pupariation in Sod1Scer\UAS.cAa-expressing animals is not significantly different from the wild-type.

The expression of Sod1Scer\UAS.cAa under the control of Scer\GAL4da.PU does not significantly affect the adult life-span, the adult locomotor capacity in negative geotaxis assays, or the numbers of dopaminergic PAL, PPM1/2, PPM3, PPL1 and PPL2 neurons in the adult brain, as compared to controls.

Expression of Sod1Scer\UAS.cAa under the control of Scer\GAL4da.PU suppresses the age-dependent loss of rhabdomeres and partially suppresses the age-dependent locomotor defect seen in YME1Ldel homozygotes.

Expression of Sod1Scer\UAS.cAa under the control of Scer\GAL4da.PU extends the lifespan of YME1Ldel homozygotes.

Expression via Scer\GAL4wor.PA and Scer\GAL80ase.PN has no effect on pupal neuroblast size or number.

Flies expressing SodScer\UAS.cAa under the control of Scer\GAL4Hand.ΔVM.Switch show no significant difference in heart function compared to controls.

Lifespan patterns of SodScer\UAS.cAa overexpression using Scer\GAL4da.G32 are not significantly different from diet-matched controls, suggesting that SodScer\UAS.cAa overexpression if not sufficient to alter the lifespan response of flies to diet.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Enhancer of
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The expression of Sod1Scer\UAS.cAa under the control of Scer\GAL4da.PU does not suppress the decreased adult life-span, the adult locomotor defects or the decreased number of dopaminergic PPL1 neurons in the adult brain, displayed by Chchd2null hemizygotes.

The shortening of the dendritic arbor in class IV ddaC neurons in third instar larvae expressing prelScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4109(2)80 is not significantly affected by co-expression of Sod1Scer\UAS.cAa.

Expression of Sod1Scer\UAS.cAa under the control of Scer\GAL4ninaE.PT fails to rescue the neurodegeneration and electrophysiology defect seen in fh1 mutant photoreceptor clones.

Co-expression of SodScer\UAS.cAa rescues the heart tube defects (dilation and impaired shortening) seen in adults expressing MarfmiRNA.cUa.Scer\UAS under the control of Scer\GAL4tin.CΔ4. In addition, the morphology of the mitochondria in the cardiomyocytes is markedly improved towards wild type.

Co-expression of SodScer\UAS.cAa under the control of Scer\GAL4GMR.PF almost completely suppresses the cln3Scer\UAS.cTa-overexpression phenotype in the eye.

Expression of SodScer\UAS.cAa under the control of Scer\GAL4Mef2.PR does not rescue the reduced viability seen in p38bΔ25 Mpk21 double mutants.

Xenogenetic Interactions
Statement
Reference

Overexpression of SodScer\UAS.cAa enhances the decreased survival phenotype of flies expressing Hsap\APPArctic.Scer\UAS.T:nec under the control of Scer\GAL4elav-C155.

Overexpression of SodScer\UAS.cAa accelerates the decline in locomotor function of flies expressing Hsap\APPScer\UAS.T:nec under the control of Scer\GAL4elav-C155.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
Sod1Scer\UAS.cAa
Sod1UAS.cAa
SodScer\UAS.cAa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Anderson
Secondary FlyBase IDs
    References (29)