FlyBase Allele Report: Dmel\Rab11[KK108297]

General Information

Symbol

Dmel\Rab11^KK108297

Species

D. melanogaster

Name

FlyBase ID

FBal0235482

Feature type

allele

Associated gene

Dmel\Rab11

Associated Insertion(s)

Carried in Construct

P{KK108297}

Also Known As

Rab11 RNAi, Rab11 v108382

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK108297}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK108297

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of inflammatory bowel disease

CEA

(Yu et al., 2014)

model of intestinal cancer

CEA

(Nie et al., 2019)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of intestinal cancer

is exacerbated by Ras85D^V12.UAS

(Nie et al., 2019)

is exacerbated by wg^{UAS.cHa.Tag:HA}

(Nie et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult midgut | adult stage, with Scer\GAL4^NP0001

(Yu et al., 2014)

centrosome, with Scer\GAL4^neur-P72

(Jauffred et al., 2013)

cyst cell of testis | third instar larval stage, with Scer\GAL4^C587

(La Marca et al., 2019)

embryonic/larval cell body glial cell | third instar larval stage, with Hsim\VP16^AD.nrv2, Scer\GAL4^{DBD.wrapper.932i}

(Coutinho-Budd et al., 2017)

embryonic/larval plasmatocyte, with Scer\GAL4^Cg.PA

(Jean et al., 2012)

enteroblast | adult stage | cell non-autonomous, with Scer\GAL4^NP0001

(Yu et al., 2014)

epithelium, with Scer\GAL4^NP1624

(Berns et al., 2014)

external sensory organ precursor cell I, with Scer\GAL4^neur-P72

(Jauffred et al., 2013)

female germline cyst, with Scer\GAL4^NP1624

(Berns et al., 2014)

gonad | male | third instar larval stage, with Scer\GAL4^C587

(La Marca et al., 2019)

intestinal stem cell | adult stage | cell non-autonomous, with Scer\GAL4^NP0001

(Yu et al., 2014)

larval neuroblast, with Scer\GAL4^insc-Mz1407

(Kakade et al., 2025)

male germline stem cell | third instar larval stage, with Scer\GAL4^C587

(La Marca et al., 2019)

Detailed Description

Statement

Reference

Expressing Rab11^KK108297 under the control of Scer\GAL4^C587 results in dissociated somatic cells and ectopic early germline cells in L3 male gonads.

(La Marca et al., 2019)

Expression of Rab11^KK108297 under the control of CtxGlia-SplitGal4 (Hsim\VP16^AD.nrv2 and Scer\GAL4^{DBD.wrapper.932i}) leads to an altered cortex glial morphology in third instar larvae when compared to controls.

(Coutinho-Budd et al., 2017)

Scer\GAL4^tj-NP1624-mediated expression results in the transformation of the normal germline cyst epithelial monolayer into two or more cell layers.

(Berns et al., 2014)

Expression of Rab11^KK108297 under the control of Scer\GAL4^{Myo31DF-NP0001} (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) results in significantly increased numbers of mitotic cells in the midgut, and cell non-autonomously leads to an increased number of cells in the intestinal stem cell-enteroblast nests, as compared to controls.

(Yu et al., 2014)

Centrosome asymmetry during cytokinesis is reduced in pI (sensory organ precursor) cells in the notum expressing Rab11^KK108297 under the control of Scer\GAL4^neur-P72 compared to that seen in wild-type pI cells, with the anterior centrosome moving earlier than in wild type.

(Jauffred et al., 2013)

Primary macrophages isolated from animals expressing Rab11^KK108297 under the control of Scer\GAL4^Cg.PA lack F-actin rich protrusions.

(Jean et al., 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

Rab11^KK108297, Scer\GAL4^Cg.PA is a suppressor of embryonic/larval plasmatocyte phenotype of Scer\GAL4^Cg.PA, mtm^UAS.mCherry

(Jean et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Rab11^KK108297 suppresses the excess F-actin rich protrusions seen in macrophages isolated from animals expressing mtm^{Scer\UAS.T:Disc\RFP-mCherry} under the control of Scer\GAL4^Cg.PA.

(Jean et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108382

P{KK108297}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Rab11^KK108297

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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