dDNase II, DNase1
Gene model reviewed during 5.39
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\DNaseII using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\DNaseII in GBrowse 2
Mapping based on 83 bx-sr recombinants.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: DNaseII CG7780
two unnamed hypomorphic alleles discovered by J. Stone seven unnamed null alleles discovered by Detwiler
Hyperploidy for 30F-35BC and 67C-70C as well as 88C-91B caused greater than 50% increase in acid deoxyribonuclease activity (MacIntyre, 1974).
The structural gene for DNase 1, one of an estimated 7 or more DNase species (Boyd, 1969). Active on native DNA at acid pH (optimum = 4.8) and in the presence of EDTA. Heterozygotes for electrophoretic alleles show two bands on gels indicating monomeric nature of enzyme. Activity of paternally inherited allele demonstrable in 0- to 1-hr embryos. Activity fluctuates during embryogenesis, is low during larval stages, rises precipitously just before pupation, and falls after eclosion (Detwiler and MacIntyre, 1978). DNase-1 activity isolated with lysosomal fraction of embryo homogenates (Detwiler and MacIntyre, 1980). Flies homozygous for hypomorphic allele are small with reduced viability; maturation of ovaries delayed for several days after eclosion; recombination normal (Grell, 1976). Homozygotes for the hypomorphic allele DNaseIIlmh accumulate low-molecular-weight, low-thermal-stability DNA, especially in the ovaries; Feulgen-positive vesicles visible in maturing oocytes near chorionic appendages (Stone, Dower, Hauseman, Cseko and Sederoff, 1983).