FlyBase Gene Report: Dmel\MsrA

General Information

Symbol

Dmel\MsrA

Species

D. melanogaster

Name

Methionine sulfoxide reductase A

Annotation Symbol

CG7266

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000565

Gene Model Status

Current

Stock Availability

11 publicly available

Enzyme Name (EC)

L-methionine (S)-S-oxide reductase (1.8.4.13)

Gene Summary

Methionine sulfoxide reductase A (MsrA) encodes a methionine-S-sulfoxide reductase involved in the response to oxidative stress. It contributes to determination of adult lifespan and neuron projection. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

Eip28/29, Eip71CD, Ecdysone-induced protein 28/29kD

Key Links

Genomic Location

Cytogenetic map

71D3-71D4

Sequence location

3L:15,511,052..15,513,202 [+]

Recombination map

3-43

RefSeq locus

NT_037436 REGION:15511052..15513202

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables peptide-methionine (S)-S-oxide reductase activity

inferred from direct assay

(Tarafdar et al., 2019, Kumar et al., 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables L-methionine (S)-S-oxide reductase activity

inferred from biological aspect of ancestor with PANTHER:PTN000019085

(GO Reference Genome Project, 2011-)

enables peptide-methionine (S)-S-oxide reductase activity

inferred from electronic annotation with InterPro:IPR002569, InterPro:IPR036509

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000019085

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in cellular response to oxidative stress

inferred from expression pattern

(Chung et al., 2010)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Chung et al., 2010)

involved_in response to oxidative stress

inferred from mutant phenotype

(Chung et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cellular response to oxidative stress

inferred from biological aspect of ancestor with PANTHER:PTN000019085

(GO Reference Genome Project, 2011-)

involved_in sulfur amino acid metabolic process

non-traceable author statement

(Andres et al., 1993)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000019085

(GO Reference Genome Project, 2011-)

located_in mitochondrion

inferred from sequence or structural similarity with UniProtKB:Q9UJ68

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

UNCLASSIFIED SULFUR OXIDOREDUCTASES, DISULFIDE AS ACCEPTOR

Protein Family (UniProt)

Belongs to the MsrA Met sulfoxide reductase family. (P08761)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

peptide-methionine (S)-S-oxide reductase activity
RHEA 14217: L-methionine (S)-S-oxide reductase activity

[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol (1.8.4.13)

RHEA 19993:

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED SULFUR OXIDOREDUCTASES, DISULFIDE AS ACCEPTOR -: This group comprises sulfur oxidoreductases using disulfide as acceptor that do not classify under other groups in FlyBase.

Protein Function (UniProtKB)

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reduction of methionine sulfoxide in proteins to methionine (PubMed:12145281, PubMed:30529269). Does not catalyze the reverse reaction involving the oxidation of methionine residues (PubMed:30529269).

(UniProt, P08761)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Eip71CD

The structural gene for 28 and 29 kilodalton (as determined by gel mobility) polypeptides (EIP28, EIP29) whose concentration in Kc cells increases detectably beginning at 30-60 min and reaches a maximum at 4-6 hr following ecdysteroid administration (Savakis, Demetri, and Cherbas, 1980, Cell 22: 665-74). Each protein exists in three isoforms with different pI's, possibly owing to acetylation.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\MsrA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P08761)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

MsrA-RA

FBtr0075553

NM_079361

980

246

MsrA-RB

FBtr0075554

NM_168622

968

242

FBtr0075552

1090

FBtr0303531

932

239

MsrA-RF

FBtr0330176

NM_001274949

1056

245

MsrA-RG

FBtr0330177

NM_001274950

980

261

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

MsrA-PA

FBpp0075308

27.7

246

5.81

FBpp0075309

27.1

242

5.33

NP_730047

AAN11775

MsrA-PC

FBpp0075307

8.9

8.49

FBpp0292565

27.2

239

6.51

FBpp0303209

27.7

245

6.09

FBpp0303210

29.4

261

6.51

M9PCL6

NP_001261879

AGB94572

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Post Translational Modification

Conjugated to URM1, a ubiquitin-like protein.

(UniProt, P08761)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MsrA using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.71

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

embryonic/larval fat body

(Andres and Cherbas, 1992)

third instar larval stage

Malpighian tubule

(Andres and Cherbas, 1992)

embryonic/larval proventriculus | posterior

(Andres and Cherbas, 1992)

embryonic/larval hemocyte

(Andres and Cherbas, 1992)

central nervous system

(Andres and Cherbas, 1992)

adult stage

adult midgut

(Andres and Cherbas, 1992)

crop

(Andres and Cherbas, 1992)

adult stage & oogenesis

nurse cell

(Andres and Cherbas, 1992)

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eye

(Xu et al., 2004)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

hindgut anlage in statu nascendi

(Fisher et al., 2012)

mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

ventral ectoderm anlage

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

larval stage

embryonic/larval midgut

(Andres and Cherbas, 1992)

epidermis

(Andres and Cherbas, 1992)

third instar larval stage

embryonic/larval anterior spiracle

(Andres and Cherbas, 1992)

embryonic/larval pharynx

(Andres and Cherbas, 1992)

embryonic/larval salivary gland

(Andres and Cherbas, 1992)

embryonic/larval lymph gland

(Andres and Cherbas, 1992)

adult stage

adult fat body

(Andres and Cherbas, 1992)

adult stage & oogenesis

oocyte

(Andres and Cherbas, 1992)

Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)

Extensive RNA blot and in situ analyses were carried out. Peaks of Eip71CD expression occur at 9-12hr of embryogenesis, at the first and second instar larval molts, in mid third instar, at pupation, and in young adults. In situ hybridization shows high levels of Eip71CD transcripts in pharynx, salivary glands, anterior spiracle, epidermis, and fat body at the start of third instar, probably as a consequence of the late 2nd instar larval ecdysone peak. Expression in the proventriculus, lymph glands, and hemocytes rises sharply at metamorphosis, probably as a result of induction by the premetamorphic ecdysone peak. Transcript disappearance from the anterior spiracle, epidermis, and fat body is concurrent with the premetamorphic ecdysone peak.

(Andres and Cherbas, 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{MsrA-GAL4.602}

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

salivary gland

(Cherbas et al., 2003)

Reporter: P{MsrA-GAL4.657}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval epidermis

(Bloomington Drosophila Stock Center, 2017, Kester and Nambu, 2011)

larval brain | restricted

(Bloomington Drosophila Stock Center, 2017)

larval brain

(Kester and Nambu, 2011)

wandering third instar larval stage

salivary gland

(Cherbas et al., 2003)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\MsrA in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\MsrA

View exonic expression by tissue for Dmel\MsrA

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000565

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39675/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000565

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000565

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000565

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7266

Flygut - An atlas of the Drosophila adult midgut

FBgn0000565

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\MsrA

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of MsrA

Transgenic constructs containing regulatory region of MsrA

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

MsrA^EY05753

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

MsrA^GD10598

viable, with Scer\GAL4^Mef2.PR

MsrA^GD10598

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

MsrA^GD10598

Sterility

Allele

fertile

MsrA^EY05753

Other Phenotypes

Allele

abnormal immune response | adult stage

abnormal immune response | adult stage, with Scer\GAL4^da.G32

MsrA^GD17043

abnormal immune response | adult stage, with Scer\GAL4^NP0001

MsrA^GD17043

abnormal oxidative stress response, with Scer\GAL4^arm.PS

MsrA^UAS.cCa

abnormal size, with Scer\GAL4^GMR.PU

MsrA^UAS.cCa

increased cell number, with Scer\GAL4^GMR.PU

MsrA^UAS.cCa

long lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

MsrA^UAS.cCa

Phenotype manifest in

Allele

eye, with Scer\GAL4^GMR.PU

MsrA^UAS.cCa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\MSRA

12 of 14

Yes

Hsap\MSRB1

1 of 14

Hsap\MSRB2

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Msra

11 of 14

Yes

Rnor\Msrb1

1 of 14

Rnor\Msrb2

1 of 14

Mus musculus (laboratory mouse) (3)

Mmus\Msra

11 of 14

Yes

Mmus\Msrb1

1 of 14

Mmus\Msrb2

1 of 14

Xenopus tropicalis (Western clawed frog) (4)

Xtro\msra.1

6 of 13

Yes

Xtro\msra.2

6 of 13

Yes

Xtro\nagpa

1 of 13

Yes

Xtro\wnt9b

1 of 13

Danio rerio (Zebrafish) (4)

Drer\msra

12 of 14

Yes

Drer\si:ch1073-358c10.1

12 of 14

Yes

Drer\msrb1a

1 of 14

Drer\msrb1b

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\msra-1

13 of 14

Yes

Anopheles gambiae (African malaria mosquito) (3)

Agam\AgaP_AGAP012394

12 of 12

Yes

Agam\AgaP_AGAP012395

12 of 12

Yes

Agam\AgaP_AGAP012396

1 of 12

Arabidopsis thaliana (thale-cress) (5)

Atha\MSRA5

11 of 13

Yes

Atha\PMSR1

8 of 13

Yes

Atha\PMSR2

8 of 13

Yes

Atha\PMSR3

8 of 13

Yes

Atha\PMSR4

8 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\MXR1

12 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPAC29E6.05c

11 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\msrA

10 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:MsrA. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

SelR

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MSRA; methionine sulfoxide reductase A

12 of 14

601250

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64995

DroID - A comprehensive database of gene and protein interactions.

FBgn0000565

MIST (protein-protein) - An integrated Molecular Interaction Database

39675

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-43

Cytogenetic map

71D3-71D4

Sequence location

3L:15,511,052..15,513,202 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

71D3-71D4

Limits computationally determined from genome sequence between P{lacW}cp309^s2172&P{lacW}l(3)j2A2^j2A2 and P{EP}Tfb2^EP572

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

71C3-71D2

(determined by in situ hybridisation)

(Cherbas et al., 1986)

Experimentally Determined Recombination Data

Location

3-43

(FlyBase, 2016)

3-37.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

82811

y¹ v¹; P{TKO.GS04211}attP40

59248

y¹ w^*; Mi{MIC}MsrA^MI14018

16671

y¹ w^67c23; P{EPgy2}MsrA^EY05753

63502

w¹¹¹⁸; PBac{IT.GAL4}MsrA^0760-G4/TM6B, Tb¹

42877

y¹ sc^* v¹ sev²¹; P{TRiP.HMS02570}attP40

81388

y¹ sc^* v¹ sev²¹; P{SAM.dCas9.GS03907}attP40

FlyORF

F001070

M{UAS-MsrA.ORF.3xHA}ZH-86Fb

7266R-1

7266R-3

v104465

v26009

w¹¹¹⁸; P{GD10598}v26009

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (57)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000565

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000565

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNase protection studies show that the 3' end of mex1 is located approximately 4kb downstream of Eip71CD, with the two genes convergently transcribed.

(Schulz et al., 1991)

The gdl transcribed region overlaps the Eip71CD transcribed region.

(Schulz et al., 1989)

Eip71CD has been cloned and sequenced.

(Cherbas et al., 1986)

Each protein exists in three isoforms with different pI's, possibly owing to acetylation.

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: MsrA Eip71CD

(FlyBase, 2009-)

Nomenclature comments

Renamed 'Eip71CD' to 'MsrA' to reflect usage in the fly literature and the wider field.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

CG7266

(Parkhitko et al., 2016, Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Sepp et al., 2008)

DROZ60MEX

(Schug et al., 1998)

EiP71CD

(Zatsepina et al., 2020)

Eip28

(Maroni, 1994)

Eip28 /29

(Cherbas, 1990.10.29)

Eip71C

(Nakahara and Carthew, 2004)

MSRA

(Bruce et al., 2018)

MsrA

(Chaturvedi et al., 2025, Haas et al., 2025, Zatsepina et al., 2020, Khoshnood et al., 2017, Vanhove et al., 2017, Kim and Johnson, 2014, Hung et al., 2013, Roesijadi et al., 2007, Kim and Gladyshev, 2006, Kumar, 2002.8.27, Kumar et al., 2002)

dMsrA

(Guan et al., 2017)

dmsrA

(Chung et al., 2010)

eip28/29

(Wang et al., 2000)

msrA

(Tarafdar et al., 2019)

Name Synonyms

Ecdysone-induced protein 28/29kD

(Graveley et al., 2011, Zeitouni et al., 2007)

Eip28/29

(Roesijadi et al., 2007)

Methionine sulfoxide reductase A

Methionine-S-sulfoxide reductase

(Hung et al., 2013)

methionine reductase A

(Kim and Johnson, 2014)

methionine sulfoxide reductase A

(Chung et al., 2010)

methionine-S-sulfoxide reductase

(Kumar et al., 2002)

Secondary FlyBase IDs

FBgn0026825

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 70 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39675

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P08761

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P08761

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P08761

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0000565

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39675/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000565

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000565

FlyMine - An integrated database for Drosophila genomics

FBgn0000565

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7266

MARRVEL_MODEL - MARRVEL (model organism gene)

39675

Linkouts

BioGRID - A database of protein and genetic interactions.

64995

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000565

DroID - A comprehensive database of gene and protein interactions.

FBgn0000565

DRSC - Results frm RNAi screens

FBgn0000565

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000565

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000565

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7266

Flygut - An atlas of the Drosophila adult midgut

FBgn0000565

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC005676

MIST (protein-protein) - An integrated Molecular Interaction Database

39675

References (127)

The following external sites may use different assemblies or annotations than FlyBase.

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