FlyBase Gene Report: Dmel\l(3)73Ah

General Information

Symbol

Dmel\l(3)73Ah

Species

D. melanogaster

Name

lethal (3) 73Ah

Annotation Symbol

CG4195

Feature Type

protein_coding_gene

FlyBase ID

FBgn0002283

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

l(3)02540

Key Links

Genomic Location

Cytogenetic map

73A10-73A10

Sequence location

3L:16,588,475..16,590,132 [+]

Recombination map

3-44

RefSeq locus

NT_037436 REGION:16588475..16590132

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables zinc ion binding

inferred from sequence model

(Ying et al., 2011)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000088533

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:Q3KNV8

(Gene Ontology Curators, 2002-)

part_of PRC1 complex

inferred from biological aspect of ancestor with PANTHER:PTN000088533

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\l(3)73Ah for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VV77)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

l(3)73Ah-RA

FBtr0075311

NM_080194

1404

222

l(3)73Ah-RB

FBtr0307336

NM_001259868

1322

222

Additional Transcript Data and Comments

Reported size (kB)

1.6 (northern blot)

(Irminger-Finger and Nothiger, 1995, McKeown et al., 1987)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

l(3)73Ah-PA

FBpp0075071

26.4

222

8.43

FBpp0298337

26.4

222

8.43

Q9VV77

NP_001246797

AFH04468

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

222 aa isoforms: l(3)73Ah-PA, l(3)73Ah-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

222 (aa); 26 (kD predicted)

(Irminger-Finger and Nothiger, 1995)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VV77

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\l(3)73Ah using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.30

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Irminger-Finger and Nothiger, 1995)

larval stage & adult stage

fat body

(Irminger-Finger and Nothiger, 1995)

oogenesis & adult stage | female

ovary

(Irminger-Finger and Nothiger, 1995)

Additional Descriptive Data

The l(3)73Ah transcript is expressed throughout development, with lowest levels in larvae, slightly higher levels in pupae, and maximal levels in adults. Adult female expression is higher than adult male expression; the signal detected in embryos is possibly maternal. Radioactive in situ hybridization with a l(3)73Ah-specific probe shows high levels of expression in the fat body of larvae and adults, and in the adult female ovary.

(Irminger-Finger and Nothiger, 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\l(3)73Ah in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\l(3)73Ah

View exonic expression by tissue for Dmel\l(3)73Ah

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0002283

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

48903/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002283

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002283

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002283

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4195

Flygut - An atlas of the Drosophila adult midgut

FBgn0002283

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of l(3)73Ah

Transgenic constructs containing regulatory region of l(3)73Ah

Aberrations (Deficiencies and Duplications) ( 13 )

Inferred from experimentation ( 13 )

Gene not disrupted in

Df(3L)st-a20

(Belote et al., 1990, McKeown et al., 1987)

Df(3L)st-e4

(Belote et al., 1990, McKeown et al., 1987)

Df(3L)st-f13

(Belote et al., 1990, McKeown et al., 1987)

In(3L)std11

(Belote et al., 1990, Gertler et al., 1989, McKeown et al., 1987)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

l(3)73Ah¹

lethal | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

l(3)73Ah^GD4693

viable, with Scer\GAL4^pnr-MD237

l(3)73Ah^GD4693

viable, with Scer\GAL4^tin.CΔ4

l(3)73Ah^GD4693

Other Phenotypes

Allele

abnormal flight, with Scer\GAL4^Mef2.PR

l(3)73Ah^GD4693

visible, with Scer\GAL4^pnr-MD237

l(3)73Ah^GD4693

wild-type

l(3)73Ah^cBa

Phenotype manifest in

Allele

adult abdomen

l(3)73Ah¹

mesonotum, with Scer\GAL4^pnr-MD237

l(3)73Ah^GD4693

myofibril, with Scer\GAL4^Mef2.PR

l(3)73Ah^GD4693

sarcomere, with Scer\GAL4^Mef2.PR

l(3)73Ah^GD4693

trichogen cell, with Scer\GAL4^pnr-MD237

l(3)73Ah^GD4693

Z disc, with Scer\GAL4^Mef2.PR

l(3)73Ah^GD4693

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (30)

Hsap\PCGF3

14 of 14

Yes

Hsap\PCGF1

5 of 14

Yes

Hsap\PCGF5

5 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DTX3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\RING1

1 of 14

Hsap\RNF2

1 of 14

Hsap\RNF8

1 of 14

Yes

Hsap\TRIM10

1 of 14

Yes

Hsap\TRIM26

1 of 14

Yes

Hsap\TRIM35

1 of 14

Yes

Hsap\TRIM50

1 of 14

Yes

Hsap\TRIM60

1 of 14

Yes

Hsap\TRIM69

1 of 14

Yes

Hsap\TRIM73

1 of 14

Yes

Hsap\TRIM74

1 of 14

Yes

Hsap\TRIM75P

1 of 14

Yes

Hsap\TRIML1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (22)

Rnor\Pcgf3

14 of 14

Yes

Rnor\Pcgf1

5 of 14

Yes

Rnor\Pcgf5

5 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

1 of 14

1 of 14

Yes

Rnor\Dtx3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Ring1

1 of 14

Rnor\Rnf2

1 of 14

Rnor\Rnf8

1 of 14

Yes

Rnor\Rnf10

1 of 14

Rnor\Traip

1 of 14

Rnor\Trim65

1 of 14

Yes

Rnor\Triml1

1 of 14

Yes

Mus musculus (laboratory mouse) (27)

Mmus\Pcgf3

13 of 14

Yes

Mmus\Pcgf5

5 of 14

Yes

Mmus\Pcgf1

4 of 14

Yes

4 of 14

3 of 14

3 of 14

1 of 14

1 of 14

Yes

Mmus\Dtx3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ring1

1 of 14

Mmus\Rnf2

1 of 14

Mmus\Rnf8

1 of 14

Yes

Mmus\Rnf10

1 of 14

Mmus\Rnf135

1 of 14

Yes

Mmus\Traip

1 of 14

Mmus\Trim5

1 of 14

Yes

Mmus\Trim12c

1 of 14

Yes

Mmus\Trim17

1 of 14

Yes

Mmus\Trim30b

1 of 14

Yes

Mmus\Trim38

1 of 14

Yes

Mmus\Trim69

1 of 14

Yes

Mmus\Trim75

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (19)

Xtro\pcgf3

11 of 13

Yes

Xtro\pcgf1

3 of 13

Yes

Xtro\pcgf5

3 of 13

Yes

Xtro\pcgf6

3 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

Yes

Xtro\dtx3

1 of 13

Yes

Xtro\LOC100485658

1 of 13

Yes

Xtro\LOC100491015

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\trim69.1

1 of 13

Xtro\trim69.2

1 of 13

Xtro\uhrf2

1 of 13

Yes

Danio rerio (Zebrafish) (26)

Drer\pcgf5a

8 of 14

Yes

Drer\pcgf5b

8 of 14

Yes

Drer\pcgf1

6 of 14

Yes

5 of 14

4 of 14

4 of 14

1 of 14

Yes

Drer\btr31

1 of 14

Yes

Drer\btr32

1 of 14

Yes

Drer\chfr

1 of 14

Drer\cop1

1 of 14

Yes

Drer\dtx3

1 of 14

Yes

Drer\ftr29

1 of 14

Drer\ftr55

1 of 14

Yes

Drer\ftr61

1 of 14

Yes

Drer\pcgf3

1 of 14

Yes

Drer\rbbp6

1 of 14

Drer\rnf2

1 of 14

Drer\rnf8

1 of 14

Yes

Drer\rnf24

1 of 14

Yes

Drer\rnf114

1 of 14

Yes

Drer\rnf151

1 of 14

Drer\si:dkey-46i9.6

1 of 14

Yes

Drer\traip

1 of 14

Drer\trim69

1 of 14

Yes

Drer\trim109

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\mig-32

10 of 14

Yes

Cele\spat-3

1 of 14

Cele\T02C1.1

1 of 14

Cele\T02C1.2

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP002533

12 of 12

Yes

Agam\AgaP_AGAP006403

4 of 12

Agam\AgaP_AGAP006402

3 of 12

Agam\AgaP_AGAP001292

1 of 12

Yes

Agam\AgaP_AGAP002073

1 of 12

Arabidopsis thaliana (thale-cress) (14)

Atha\DRIP2

7 of 13

Yes

Atha\AT3G23060

6 of 13

Yes

Atha\DRIP1

6 of 13

Yes

Atha\AT1G35183

2 of 13

Yes

Atha\AT1G18660

1 of 13

Atha\AT1G19310

1 of 13

Atha\AT1G28080

1 of 13

Yes

Atha\AT3G27330

1 of 13

Atha\AT3G54360

1 of 13

Yes

Atha\AT5G13250

1 of 13

Yes

Atha\BRCA1

1 of 13

Yes

Atha\COP1

1 of 13

Atha\RING1A

1 of 13

Atha\RING1B

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\IRC20

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\rhp18

1 of 12

Yes

Spom\SPAC144.05

1 of 12

Yes

Spom\SPCC548.05c

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:l(3)73Ah. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

Psc

6 of 13

Su(z)2

6 of 13

Sce

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PCGF3; polycomb group ring finger 3

14 of 14

617543

PCGF1; polycomb group ring finger 1

5 of 14

610231

PCGF5; polycomb group ring finger 5

5 of 14

617407

PCGF6; polycomb group ring finger 6

4 of 14

607816

BMI1; BMI1 proto-oncogene, polycomb ring finger

3 of 14

164831

COMMD3-BMI1; COMMD3-BMI1 readthrough

3 of 14

PCGF2; polycomb group ring finger 2

3 of 14

600346

TURNPENNY-FRY SYNDROME; TPFS

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

l(3)73Ah - Nprl3

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

l(3)73Ah - Sce

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

l(3)73Ah - grh

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

71800

DroID - A comprehensive database of gene and protein interactions.

FBgn0002283

MIST (protein-protein) - An integrated Molecular Interaction Database

48903

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Polycomb repressive complex

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Transcriptional Regulation by E2F6

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-44

Cytogenetic map

73A10-73A10

Sequence location

3L:16,588,475..16,590,132 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

73A10-73A10

Limits computationally determined from genome sequence between P{lacW}l(3)j10E8^j10E8&P{PZ}l(3)10532¹⁰⁵³² and P{PZ}Baldspot⁰²²⁸¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

73A9-73A10

(determined by in situ hybridisation)

(Spradling et al., 1999)

73A9-73A10

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-44

(FlyBase, 2016)

3-39.2

(Comeron et al., 2012)

Left of (cM)

(Belote et al., 1990)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

44011

y¹ v¹; P{TRiP.HMS02725}attP40

80221

y¹ sc^* v¹ sev²¹; P{TOE.GS02637}attP40

11571

P{PZ}l(3)73Ah⁰²⁵⁴⁰ ry⁵⁰⁶/TM3, ry^RK Sb¹ Ser¹

11605

4195R-1

4195R-4

HMS02725

y¹ v¹; P{TRiP.HMS02725}attP40/CyO

VDRC

v101417

P{KK109105}VIE-260B

v43120

w¹¹¹⁸; P{GD4693}v43120

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE11339

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0002283

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RH10038

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0002283

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

l(3)73Ah amino acid sequence comparison reveals a striking homology to the entire sequence of mammalian oncogenes mel-18 and bmi-1 and to the zinc-finger containing N-terminal domain of Psc and Su(z)2. l(3)73Ah shares 3' untranslated sequence with tra. l(3)73Ah transcription is temporally and spatially regulated with maximal expression in adult females.

(Irminger-Finger and Nothiger, 1995)

Relationship to Other Genes

Source for database merge of

Source for merge of: l(3)73Ah l(3)02540

(Spradling et al., 1999)

Source for merge of: l(3)73Ah CG4195

(Misra, 2000.7.28)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG4195

(Hosono et al., 2015, Ying et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009)

I(3)73Ah

(Nahvi et al., 2009)

L(3)73Ah

(Martinez, 2025, Kang et al., 2022, Kahn et al., 2016, Emmons et al., 2009)

l(3)02540

(Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

l(3)133.18

l(3)73Ah

(Bonnet et al., 2026, Kang et al., 2022, Transgenic RNAi Project members, 2017-, Lee et al., 2015, Saunders et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Du et al., 2011, Mudiganti et al., 2010)

Name Synonyms

lethal (3) 73Ah

lethal(3)73Ah

(Irminger-Finger, 1995.2.3)

Secondary FlyBase IDs

FBgn0010783
FBgn0036644

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

48903

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VV77

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VV77

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VV77

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0002283

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

48903/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002283

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002283

FlyMine - An integrated database for Drosophila genomics

FBgn0002283

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4195

MARRVEL_MODEL - MARRVEL (model organism gene)

48903

Linkouts

BioGRID - A database of protein and genetic interactions.

71800

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0002283

DroID - A comprehensive database of gene and protein interactions.

FBgn0002283

DRSC - Results frm RNAi screens

FBgn0002283

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002283

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0002283

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4195

Flygut - An atlas of the Drosophila adult midgut

FBgn0002283

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031557

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Polycomb repressive complex

MIST (protein-protein) - An integrated Molecular Interaction Database

48903

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Transcriptional Regulation by E2F6

References (51)

The following external sites may use different assemblies or annotations than FlyBase.

1.30

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