FlyBase Gene Report: Dmel\cav

General Information

Symbol

Dmel\cav

Species

D. melanogaster

Name

caravaggio

Annotation Symbol

CG6219

Feature Type

protein_coding_gene

FlyBase ID

FBgn0026257

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

caravaggio (cav) is a fast evolving gene that encodes HP1/ORC Associated Protein (HOAP). HOAP is a DNA binding protein strongly enriched at chromosome ends and required for telomere capping. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

HOAP, anon1G5, HP1/ORC-associated protein, p55, anon fe 1G5

Key Links

Genomic Location

Cytogenetic map

95F2-95F2

Sequence location

3R:24,221,103..24,223,528 [+]

Recombination map

3-84

RefSeq locus

NT_033777 REGION:24221103..24223528

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:B7Z0L8

(Raffa et al., 2009)

inferred from physical interaction with UniProtKB:Q9VR09

(Joppich et al., 2009)

inferred from physical interaction with UniProtKB:P05205

(Badugu et al., 2003)

enables telomeric repeat DNA binding

inferred from mutant phenotype

(Raffa et al., 2009, Badugu et al., 2003, Shareef et al., 2001)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in telomere capping

inferred from mutant phenotype

(Joppich et al., 2009, Raffa et al., 2009, Badugu et al., 2003, Shareef et al., 2001)

inferred from expression pattern

(Cenci et al., 2003)

involved_in telomere maintenance

inferred from mutant phenotype

(Bi et al., 2005)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in chromosome, centromeric region

inferred from direct assay

(Rashkova et al., 2002)

located_in chromosome, telomeric region

inferred from direct assay

(Gao et al., 2011, Dubruille et al., 2010, Gao et al., 2010, Cenci et al., 2003, Rashkova et al., 2002)

located_in nucleus

inferred from direct assay

(Dubruille et al., 2010, Shareef et al., 2001)

part_of telomere cap complex

inferred from direct assay

(Joppich et al., 2009, Raffa et al., 2009, Badugu et al., 2003, Shareef et al., 2001)

inferred from direct assay

(Raffa et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in chromosome

inferred from experiment

(Zhang et al., 2016, Cenci et al., 2015, Gao et al., 2010, Raffa et al., 2010, Komonyi et al., 2009, Raffa et al., 2009, Badugu et al., 2003, Cenci et al., 2003, Shareef et al., 2001)

located_in nucleus

inferred from experiment

(Zhang et al., 2016, Cenci et al., 2015, Gao et al., 2010, Raffa et al., 2010, Komonyi et al., 2009, Raffa et al., 2009, Badugu et al., 2003, Cenci et al., 2003)

Gene Group (FlyBase)

HIPHOP-HOAP TELOMERE-CAPPING COMPLEX

MTV COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

HIPHOP-HOAP TELOMERE-CAPPING COMPLEX -: The HipHop-HOAP telomere-capping complex binds to the double stranded portion of telomeric chromatin and recruits Su(var)205 (Heterochromatin Protein 1), a structural component of heterochromatin involved in gene repression, to telomeres. Also recruits the MTV complex to form the terminin telomere-capping complex, which binds to chromosome ends in a sequence-independent manner and prevents telomere fusion. (Adapted from ComplexPortal.)
MTV COMPLEX -: The Moi-Tea-Ver (MTV) complex binds single-stranded DNA in a sequence independent manner, protecting the DNA from cleavage by endonucleases. Binds the HipHop-HOAP complex to form terminin telomere-capping complex which binds to chromosome ends in a sequence-independent manner and prevents telomere fusion. (Adapted from ComplexPortal.)

Protein Function (UniProtKB)

Part of the HipHop-HOAP complex that recruits the MTV complex to form the terminin telomere-capping complex, which binds to chromosome ends in a sequence-independent manner and prevents telomere fusion (PubMed:11408576, PubMed:12510197, PubMed:12826664, PubMed:19181850, PubMed:19190990, PubMed:20057353). Telomere capping is independent of the origin recognition complex (ORC) (PubMed:12510197).

(UniProt, Q95RV2)

Summary (Interactive Fly)

poorly conserved component of the telomere capping complex - prevents end fusion by maintaining a chromatin state that is independent of the underlying DNA sequence

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\cav for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q95RV2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.39

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

cav-RA

FBtr0084558

NM_079753

1520

345

cav-RB

FBtr0084559

NM_170133

1226

337

cav-RD

FBtr0084557

NM_170134

1649

337

cav-RE

FBtr0084556

NM_170135

1776

343

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

cav-PA

FBpp0083943

39.4

345

4.64

FBpp0083944

38.5

337

4.64

NP_732969

AAF56260

cav-PD

FBpp0083942

38.5

337

4.64

NP_732970

AAN13989

cav-PE

FBpp0083941

39.2

343

4.65

E4NKN6

NP_732971

AAN13990

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

337 aa isoforms: cav-PB, cav-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the HipHop-HOAP telomere capping complex, composed of at least HipHop and cav/HOAP, and may include Su(var)205/HP1; HipHop and cav/HOAP, but not Su(var)205, are interdependent for their protein stability (PubMed:20057353). Interacts with HipHop (via N-terminus) (PubMed:20057353). Interacts (via C-terminus) with Su(var)205/HP1 dimer (via hinge and chromoshadow domain) and Orc1; possibly interacts with other components of the origin recognition complex (ORC) (PubMed:11408576, PubMed:12826664, PubMed:19181850). Each molecule of cav/HOAP interacts with 2 molecules of Su(var)205/HP1 (PubMed:12826664). The HipHop-HOAP complex recruits the MTV complex, consisting of moi/modigliani, tea and ver/verrocchio, to telomeres, forming the terminin telomere-capping complex (PubMed:19181850, PubMed:20679394). Interacts with moi/modigliani; the interaction is direct (PubMed:19181850). Interacts with ver/verrochio; the interaction is direct (PubMed:20679394). Interacts with HP6, which is also part of the terminin complex (PubMed:19190990). Interacts (via N-terminus) with peo/pendolino (via N-terminus); the interaction is direct (PubMed:26110638).

(UniProt, Q95RV2)

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q95RV2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cav using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.59

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

distribution deduced from reporter or direct label

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

salivary gland

• chromosome, telomeric region

(Raffa et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in chromosome, centromeric region

inferred from direct assay

(Rashkova et al., 2002)

located_in chromosome, telomeric region

inferred from direct assay

(Gao et al., 2011, Dubruille et al., 2010, Gao et al., 2010, Cenci et al., 2003, Rashkova et al., 2002)

located_in nucleus

inferred from direct assay

(Dubruille et al., 2010, Shareef et al., 2001)

part_of telomere cap complex

inferred from direct assay

(Joppich et al., 2009, Raffa et al., 2009, Badugu et al., 2003, Shareef et al., 2001)

inferred from direct assay

(Raffa et al., 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\cav in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\cav

View exonic expression by tissue for Dmel\cav

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026257

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42881/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026257

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026257

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026257

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6219

Flygut - An atlas of the Drosophila adult midgut

FBgn0026257

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\cav

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of cav

Transgenic constructs containing regulatory region of cav

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)crb-F89-4

(Cenci et al., 2003)

Df(3R)Exel6198

(Ryder, 2004.4.26)

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PI

cav^GD4920

lethal, with Scer\GAL4^en.PU

cav^GD4920

lethal, with Scer\GAL4^insc-Mz1407

cav^GD4920

lethal (with Df(3R)Exel6198)

cav¹

lethal | embryonic stage | recessive

cav²²⁴⁸

lethal | male limited, with Scer\GAL4^Act5C.PU

cav^RNAi.UAS

lethal | male limited | maternal effect, with Scer\GAL4^Act5C.PU

cav^RNAi.UAS

lethal | recessive

cav¹

lethal - all die during embryonic stage | male limited | recessive

cav¹

partially lethal - majority die | dominant | male limited

cav²²⁴⁸

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

cav^GD4920

viable, with Scer\GAL4^Mef2.PR

cav^GD4920

viable, with Scer\GAL4^pnr-MD237

cav^GD4920

Sterility

Allele

fertile

cav^myc

male semi-sterile, with cav¹/Df(3R)Exel6198

cav^HipHop.GFP

male semi-sterile (with Df(3R)Exel6198), with cav^HipHop.GFP

cav¹

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

cav^GD4920

abnormal mitotic cell cycle

abnormal mitotic cell cycle | larval stage

cav¹

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

cav^GD4920

abnormal neuroanatomy | larval stage (with cav¹)

cav²²⁴⁸

abnormal neuroanatomy | larval stage (with cav²²⁴⁸)

cav¹

abnormal size | adult stage, with Scer\GAL4^ey.PH

cav^GD4920

some die during embryonic stage | recessive

cav¹

suppressor of variegation | dominant | partially, with In(1)w^m4

cav¹

visible, with Scer\GAL4^pnr-MD237

cav^GD4920

visible | adult stage, with Scer\GAL4^ey.PH

cav^GD4920

visible | adult stage, with Scer\GAL4^nub.PK

cav^GD4920

Phenotype manifest in

Allele

chromosome, telomeric region

cav¹

chromosome | adult stage | male, with cav¹/Df(3R)Exel6198

cav^HipHop.GFP

chromosome | adult stage | male (with Df(3R)Exel6198), with cav^HipHop.GFP

cav¹

chromosome | larval stage

cav¹

eye, with Scer\GAL4^ey.PH

cav^GD4920

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

cav^GD4920

larval neuroblast

cav¹

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

cav^GD4920

mesonotum, with Scer\GAL4^pnr-MD237

cav^GD4920

metaphase & condensed nuclear chromosome

cav¹

mitotic metaphase

cav¹

neuroblast | larval stage (with cav¹)

cav²²⁴⁸

neuroblast | larval stage (with cav²²⁴⁸)

cav¹

spermatid, with cav¹/Df(3R)Exel6198

cav^HipHop.GFP

spermatid (with Df(3R)Exel6198), with cav^HipHop.GFP

cav¹

trichogen cell, with Scer\GAL4^pnr-MD237

cav^GD4920

wing blade, with Scer\GAL4^nub.PK

cav^GD4920

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:cav. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

cav - HP1b

two hybrid

(Hu et al., 2017.6.13)

cav - HP6

pull down, anti tag western blot

(Joppich et al., 2009)

cav - HipHop

anti tag coimmunoprecipitation, western blot, peptide massfingerprinting, pull down, anti tag western blot, chromatography technology, molecular sieving, molecular weight estimation by staining, anti bait coimmunoprecipitation

(Vedelek et al., 2015, Gao et al., 2010)

cav - Mvd

experimental knowledge based

(Guruharsha et al., 2011)

cav - Orc1

pull down, autoradiography

(Badugu et al., 2003)

cav - Orc2

anti bait coimmunoprecipitation, western blot

(Shareef et al., 2001)

cav - Orc3

pull down, autoradiography

(Badugu et al., 2003)

cav - Orc6

pull down, autoradiography, anti bait coimmunoprecipitation, western blot

(Badugu et al., 2003, Shareef et al., 2001)

cav - Sse

pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Cipressa et al., 2016)

cav - moi

pull down, anti tag western blot

(Raffa et al., 2009)

cav - mre11

anti tag coimmunoprecipitation, anti tag western blot

(On et al., 2021)

cav - nbs

anti tag coimmunoprecipitation, anti tag western blot

(On et al., 2021)

cav - peo

pull down, anti tag western blot, two hybrid, western blot

(Cenci et al., 2015)

cav - tea

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Zhang et al., 2016)

cav - ver

pull down, anti tag western blot

(Raffa et al., 2010)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

cav

enhanceable

HipHop

(Dubruille and Loppin, 2015)

cav

suppressible

moi

(Dubruille and Loppin, 2015)

cav

enhanceable

nbs

(Oikemus et al., 2006)

suppressible

(Li et al., 2011)

enhanceable

(Oikemus et al., 2006)

cav

enhanceable

ver

(Dubruille and Loppin, 2015)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

nbs

enhanceable

cav

(Oikemus et al., 2006)

suppressible

(Li et al., 2011)

enhanceable

(Oikemus et al., 2006)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q95RV2 )

Linkouts

BioGRID - A database of protein and genetic interactions.

67812

DroID - A comprehensive database of gene and protein interactions.

FBgn0026257

MIST (protein-protein) - An integrated Molecular Interaction Database

42881

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-84

Cytogenetic map

95F2-95F2

Sequence location

3R:24,221,103..24,223,528 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

95F2-95F2

Limits computationally determined from genome sequence between P{PZ}Syx1A⁰⁶⁷³⁷&P{PZ}Syx1A¹⁰⁶⁶⁰ and P{PZ}crb⁰⁷²⁰⁷&P{PZ}BRWD3⁰⁵⁸⁴²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

95D-95E

(determined by in situ hybridisation)

(Shareef et al., 2001, Schmid et al., 1999)

Experimentally Determined Recombination Data

Location

3-84

(FlyBase, 2016)

3-82.8

(Comeron et al., 2012)

Left of (cM)

(Cenci et al., 2003)

Right of (cM)

(Cenci et al., 2003)

Notes

3-85.2

(Cenci et al., 2003)

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

607409

w^*; TI{TI}cav^EGFP

63688

y¹ v¹; P{TRiP.HMJ30256}attP40/CyO

64180

cav¹ ca¹/TM6B, Tb¹ ca¹

604124

w¹¹¹⁸; L^*/CyO; P{SX4.lexA::HG}cav^S38-2/TM6B, Tb¹

13155

y¹; P{3'SUPor-P}KG00877b P{5'SUPor-P}KG00877a, ry⁵⁰⁶ twin^KG00877 cav^KG00877/TM3, Sb¹ Ser¹

Kyoto

203904

y¹ w^67c23; P{GSV6}twin^GS12209/TM3, Sb¹ Ser¹

NIG-Fly

6219R-1

P{NIG.6219R}1

HMJ30256

y¹ v¹; P{TRiP.HMJ30256}attP40/CyO

VDRC

v15022

w¹¹¹⁸ P{GD4920}v15022

v15021

w¹¹¹⁸; P{GD4920}v15021

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (85)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD09927

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0026257

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0026257

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2R+ : A Tag:FLAG was inserted in the endogenous cav locus using CRISPR/Cas9.
(On et al., 2021)

Other Comments

cav protein binds specific heterochromatin satellite DNA sequences in gel mobility shift assays.

(Shareef et al., 2001)

Mutant larvae have increased frequencies of telomeric fusions in brain cells.

(Cenci et al., 1999)

Quantifying rates of protein sequence divergence within and between species reveals that the Drosophila genome harbors a substantial proportion of genes with a very high divergence rate.

(Schmid and Tautz, 1997)

Relationship to Other Genes

Source for database merge of

Source for merge of: cav Hoap

(Cenci et al., 2002)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: anon- EST:fe1G5 CG6219

(Kodira, 1999.11)

Source for identity of: Hoap CG6219

(Kellum, 2001.3.6)

Nomenclature comments

Etymology

The gene is named "caravaggio", because the linear multicentric chromosomes that characterize the mutant phenotype resemble little trains; there is an Italian train named "Caravaggio" in memory of the famous painter.

(Cenci et al., 2003)

Synonyms and Secondary IDs (23)

Reported As

Symbol Synonym

1G5

(Tautz and Schmid, 1998)

Anon1G5

(Rand et al., 2000, Weinreich and Rand, 2000)

CG6219

(Hosono et al., 2015, Perkins et al., 2009)

Caravaggio

(Hiatt et al., 2007)

Cav

(Cheng et al., 2018)

Cav/HOAP

(Meyer-Nava et al., 2020)

HOAP

(Lin et al., 2025, Vicars et al., 2025, Melnikova and Golovnin, 2023, Sokolova et al., 2023, Warecki et al., 2023, Porrazzo et al., 2022, Reddy et al., 2022, Vedelek et al., 2021, Vernizzi and Lehner, 2021, Vicars et al., 2021, Cacchione et al., 2020, Kordyukova et al., 2020, Hanlon et al., 2018, Cicconi et al., 2017, Colmenares et al., 2017, Kurzhals et al., 2017, Cipressa et al., 2016, Dubruille and Loppin, 2015, Vedelek et al., 2015, Fulcher et al., 2014, Messina et al., 2014, Zhang et al., 2014, Morciano et al., 2013, Raffa et al., 2013, Wesolowska et al., 2013, Dubruille et al., 2012, Burgio et al., 2011, Li et al., 2011, Raffa et al., 2011, Dubruille et al., 2010, Raffa et al., 2010, Joppich et al., 2009, Komonyi et al., 2009, Raffa et al., 2009, Cenci et al., 2008, Rong, 2008, Li et al., 2007, Oikemus et al., 2007, Ciapponi et al., 2006, Hediger and Gasser, 2006, Heun et al., 2006, Oikemus et al., 2006, Badugu et al., 2005, Bi et al., 2005, Cenci et al., 2005, Ciapponi et al., 2005, Dimitri et al., 2005, Raffa et al., 2005, Wallace and Orr-Weaver, 2005, Bi et al., 2004, Ciapponi et al., 2004, Oikemus et al., 2004, Oikemus et al., 2004, Purdy and Su, 2004, Badugu et al., 2003, Biessmann and Mason, 2003, Cenci et al., 2003, Pardue and DeBaryshe, 2003, Shareef et al., 2003, Gerbi and Bielinsky, 2002, Li et al., 2002, Rashkova et al., 2002, Shaffer et al., 2002, Shareef et al., 2001)

Hoap

(Kellum, 2001.3.6, Schmid and Tautz, 1997)

anon fe 1G5

(Shareef et al., 2003, Shareef et al., 2001)

anon-EST:fe1G5

cav

(Cacchione et al., 2025, Cancian et al., 2022, Chen et al., 2022, Porrazzo et al., 2022, Porrazzo et al., 2022, Vernizzi and Lehner, 2021, Saint-Leandre et al., 2020, Tiwari et al., 2019, Hu et al., 2017.6.13, López-Panadès and Casacuberta, 2016, Zhang et al., 2016, Cenci et al., 2015, Dietz et al., 2015, Dubruille and Loppin, 2015, Kuang et al., 2014, Zhang et al., 2014, Raffa et al., 2013, Dubruille et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kurzhals et al., 2011, Li et al., 2011, Raffa et al., 2011, Reis et al., 2011, Dubruille et al., 2010, Gao et al., 2010, Kong et al., 2010, Raffa et al., 2010, Anderson et al., 2009, Komonyi et al., 2009, Raffa et al., 2009, Cenci et al., 2008, Frydrychova et al., 2008, Musarò et al., 2008, Rong, 2008, Rong, 2008, Li et al., 2007, Shaffer et al., 2006, Zaessinger et al., 2006, Bi et al., 2005)

cav/HOAP

(Lee et al., 2017)

hoap

(Gao et al., 2011, Gao et al., 2010)

p55

(Shareef et al., 2003, Shareef et al., 2001)

Name Synonyms

Drosophila anonymous fast evolving 1G5

(Shareef et al., 2003)

HP1 and Orc-associated protein

(Gao et al., 2011)

HP1-ORC associated protein

(Vedelek et al., 2015)

HP1/ORC-Associated Protein

(Li et al., 2011)

HP1/ORC-associated protein

(Dubruille et al., 2010, Shareef et al., 2003, Shareef et al., 2001)

anon-fast-evolving-1G5

anonymous fast evolving gene IG5

(Cenci et al., 2002)

caravaggio

(López-Panadès and Casacuberta, 2016, Kuang et al., 2014, Raffa et al., 2013, Wesolowska et al., 2013, Dubruille et al., 2012, Li et al., 2011, Dubruille et al., 2010, Gao et al., 2010, Raffa et al., 2010, Komonyi et al., 2009, Cenci et al., 2008, Frydrychova et al., 2008, Musarò et al., 2008, Rong, 2008, Elde and Malik, 2007, Cenci et al., 1999)

Secondary FlyBase IDs

FBgn0020360

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 77 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42881

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q95RV2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q95RV2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q95RV2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0026257

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42881/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0026257

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0026257

FlyMine - An integrated database for Drosophila genomics

FBgn0026257

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6219

MARRVEL_MODEL - MARRVEL (model organism gene)

42881

Linkouts

BioGRID - A database of protein and genetic interactions.

67812

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0026257

DroID - A comprehensive database of gene and protein interactions.

FBgn0026257

DRSC - Results frm RNAi screens

FBgn0026257

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0026257

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0026257

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6219

Flygut - An atlas of the Drosophila adult midgut

FBgn0026257

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

42881

References (160)

The following external sites may use different assemblies or annotations than FlyBase.

0.59

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