FlyBase Gene Report: Dmel\Gyf

General Information

Symbol

Dmel\Gyf

Species

D. melanogaster

Name

Gigyf

Annotation Symbol

CG11148

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039936

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

Gigyf (Gyf) encodes a protein that is necessary for maintenance of neuromuscular homeostasis. It regulates protein translation, insulin/IGF signaling pathway and autophagy. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

102E5-102E5

Sequence location

4:853,557..867,025 [-]

Recombination map

4-0

RefSeq locus

NC_004353 REGION:853557..867025

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables mRNA regulatory element binding translation repressor activity

inferred from mutant phenotype

(Ruscica et al., 2019)

enables protein binding

inferred from physical interaction with UniProtKB:P23128

(Peter et al., 2019, Ruscica et al., 2019)

inferred from physical interaction with UniProtKB:A0A0B4LEZ3, UniProtKB:A1Z7K9, UniProtKB:Q7K126, UniProtKB:Q8IMX1, UniProtKB:Q94547, UniProtKB:Q95RR8, UniProtKB:Q9VEN9, UniProtKB:Q9VKK1, UniProtKB:Q9VVI2, UniProtKB:X2JCC3

(Ruscica et al., 2019)

inferred from physical interaction with UniProtKB:E1JIV5

(Ruscica et al., 2019)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables mRNA regulatory element binding translation repressor activity

inferred from biological aspect of ancestor with PANTHER:PTN004461388

(GO Reference Genome Project, 2011-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in muscle cell cellular homeostasis

inferred from genetic interaction with FLYBASE:Atg1; FB:FBgn0260945,FLYBASE:Atg13; FB:FBgn0261108

(Kim et al., 2015)

involved_in neuron cellular homeostasis

inferred from genetic interaction with FLYBASE:Atg1; FB:FBgn0260945,FLYBASE:Atg13; FB:FBgn0261108

(Kim et al., 2015)

involved_in regulation of autophagy

inferred from genetic interaction with FLYBASE:Atg1; FB:FBgn0260945,FLYBASE:Atg13; FB:FBgn0261108

(Kim et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in negative regulation of translational initiation

inferred from biological aspect of ancestor with PANTHER:PTN004461388

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

part_of eukaryotic translation initiation factor 4F complex

inferred from direct assay

(Ruscica et al., 2019)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN004461388

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the GIGYF family. (Q7KQM6)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:31114929). In the 4EHP-GYF2 complex, promotes translational repression and decay of mRNA targets by recruiting and bridging the association of the 4EHP complex with decapping effector proteins, such as me31B and Patr-1, and the deadenylation CCR4-NOT complex (PubMed:31114929). Involved in regulating starvation-induced, developmental and physiological autophagy, which is critical for eliminating ubiquitinated proteins and dysfunctional organelles in order to maintain tissue homeostasis (PubMed:26086452).

(UniProt, Q7KQM6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gyf for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KQM6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

6S8R

Comments on Gene Model

Gene model reviewed during 5.55

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Gene model reviewed during 6.03

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gyf-RD

FBtr0300882

NM_143693

4892

1567

Gyf-RF

FBtr0300884

NM_205878

4898

1567

Gyf-RG

FBtr0300885

NM_001169356

4919

1574

Gyf-RH

FBtr0300886

NM_001169357

5268

1574

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Gyf-PD

FBpp0290104

172.9

1567

7.05

NP_651950

AAF59406

Gyf-PF

FBpp0290106

172.9

1567

7.05

NP_995600

AAS64612

Gyf-PG

FBpp0290107

173.7

1574

7.11

FBpp0290108

173.7

1574

7.11

Q7KQM6

NP_001162828

ACZ95097

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1567 aa isoforms: Gyf-PD, Gyf-PF

1574 aa isoforms: Gyf-PG, Gyf-PH

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the 4EHP-GYF2 complex, composed of at least eIF4EHP and Gyf (PubMed:31114929). Interacts (via N-terminus) with eIF4EHP; interaction is required for eIF4EHP-mediated translational repression and mRNA decay (PubMed:31114929). Interacts (via me31B binding motif) with the decapping activator DDX6/ME31B (via RecA-like domain 2), and also interacts (via GYF domain) with the decapping effector protein Patr-1 (PubMed:31114929, PubMed:31439631). Also interacts with other decapping effector proteins, such as Edc3 and Ge-1 (PubMed:31114929). Interacts with CCR4-NOT deadenylase complex members Not1, Not3, Pop2 and twin, and other components of the deadenylation complexes such as Rga, PAN2 and PAN3 (PubMed:31114929).

(UniProt, Q7KQM6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

6S8R

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7KQM6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gyf using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG11148_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.92

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Kim et al., 2015)

Additional Descriptive Data

Gyf transcript is detected at all developmental stages tested with the relatively low levels in the early larval stages.

(Kim et al., 2015)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

ovary

(Pisa et al., 2009)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Kim et al., 2015)

Additional Descriptive Data

Gyf protein is detected at all developmental stages tested with the relatively low levels in the larval stages.

(Kim et al., 2015)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of eukaryotic translation initiation factor 4F complex

inferred from direct assay

(Ruscica et al., 2019)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gyf in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gyf

View exonic expression by tissue for Dmel\Gyf

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43842/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039936

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039936

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039936

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11148

Flygut - An atlas of the Drosophila adult midgut

FBgn0039936

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gyf

Transgenic constructs containing regulatory region of Gyf

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(4)C3

(Podemski et al., 2004)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Gyf^GD7214

viable, with Scer\GAL4^Mef2.PR

Gyf^GD7214

viable, with Scer\GAL4^pnr-MD237

Gyf^GD7214

viable, with Scer\GAL4^tin.CΔ4

Gyf^GD7214

Sterility

Allele

female fertile (with Df(4)ED6382)

female fertile (with Df(4)O2)

Other Phenotypes

Allele

abnormal flight | recessive

Gyf^MI00455

abnormal locomotor behavior | adult stage | dominant | progressive

Gyf^MI00455

abnormal locomotor behavior | adult stage | progressive (with Dp(4;3)RC049)

Gyf^MI00455

abnormal locomotor behavior | adult stage | recessive

Gyf^MI00455

short lived

Gyf^MI00455

Phenotype manifest in

Allele

adult somatic muscle cell

Gyf^MI00455

autolysosome

Gyf^MI00455

autophagosome

Gyf^MI00455

medulla

Gyf^MI00455

mitochondrion

Gyf^MI00455

Z disc

Gyf^MI00455

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\GIGYF2

10 of 14

Yes

Hsap\GIGYF1

9 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (2)

Rnor\Gigyf1

9 of 14

Yes

Rnor\Gigyf2

3 of 14

Yes

Mus musculus (laboratory mouse) (2)

Mmus\Gigyf1

10 of 14

Yes

Mmus\Gigyf2

10 of 14

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\gigyf1

8 of 13

Yes

Xtro\gigyf2

5 of 13

Yes

Xtro\pih1d2

2 of 13

Xtro\fip1l1

1 of 13

Danio rerio (Zebrafish) (3)

Drer\gigyf2

10 of 14

Yes

Drer\gigyf1b

9 of 14

Yes

Drer\gigyf1a

7 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\gyf-1

7 of 14

Yes

Cele\T13G4.1

2 of 14

Yes

Cele\C06E2.1

1 of 14

Yes

Cele\K11H3.4

1 of 14

Yes

Cele\sao-1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP004310

9 of 12

Yes

Arabidopsis thaliana (thale-cress) (8)

Atha\AT5G42950

3 of 13

Yes

Atha\AT1G24300

2 of 13

Yes

Atha\AT1G27430

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\NERD

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\SMY2

5 of 13

Yes

Scer\SYH1

5 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\mpd2

6 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Gyf. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Parkinson disease 11, susceptibility to

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 2 )

Allele

Disease

Evidence

References

Gyf^GD7214

model of developmental disorder of mental health

CEA

(Stessman et al., 2017)

Gyf^KK101931

model of developmental disorder of mental health

CEA

(Stessman et al., 2017)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GIGYF2; GRB10 interacting GYF protein 2

10 of 14

612003

PARKINSON DISEASE 11, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO; PARK11

GIGYF1; GRB10 interacting GYF protein 1

9 of 14

612064

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Gyf - Edc3

anti tag coimmunoprecipitation, anti tag western blot

(Ruscica et al., 2019)

Gyf - Ge-1

anti tag coimmunoprecipitation, anti tag western blot

(Ruscica et al., 2019)

Gyf - Gnpda

experimental knowledge based

(Guruharsha et al., 2011)

Gyf - Lkb1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Gyf - Not1

anti tag coimmunoprecipitation, anti tag western blot

(Ruscica et al., 2019)

Gyf - Not3

anti tag coimmunoprecipitation, anti tag western blot

(Ruscica et al., 2019)

Gyf - PAN2

anti tag coimmunoprecipitation, anti tag western blot

(Ruscica et al., 2019)

Gyf - PAN3

anti tag coimmunoprecipitation, anti tag western blot

(Ruscica et al., 2019)

Gyf - Patr-1

anti tag coimmunoprecipitation, anti tag western blot, pull down, molecular weight estimation by coomasie staining

(Ruscica et al., 2019)

Gyf - Pop2

anti tag coimmunoprecipitation, anti tag western blot

(Ruscica et al., 2019)

Gyf - Raf

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

Gyf - Rga

anti tag coimmunoprecipitation, anti tag western blot

(Ruscica et al., 2019)

Gyf - eIF4EHP

anti tag coimmunoprecipitation, anti tag western blot, experimental knowledge based

(Ruscica et al., 2019, Guruharsha et al., 2011)

Gyf - me31B

anti tag coimmunoprecipitation, anti tag western blot, pull down, molecular weight estimation by staining, western blot, x-ray crystallography

(Peter et al., 2019, Ruscica et al., 2019)

Gyf - twin

anti tag coimmunoprecipitation, anti tag western blot

(Ruscica et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Atg1|Atg13

suppressible

Gyf

(Kim et al., 2015)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q7KQM6 )

Linkouts

BioGRID - A database of protein and genetic interactions.

68666

DroID - A comprehensive database of gene and protein interactions.

FBgn0039936

MIST (protein-protein) - An integrated Molecular Interaction Database

43842

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

4-0

Cytogenetic map

102E5-102E5

Sequence location

4:853,557..867,025 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

102E5-102E5

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

4-0

(FlyBase, 2016)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

53752

P{UASp-Gyf.EGFP.N}1, w^*

53753

w^*; P{UASp-Gyf.EGFP.N}3

28896

y¹ v¹; P{TRiP.HM05106}attP2

31010

y¹ w^*; Mi{MIC}Gyf^MI00455

98492

y¹ w^*; TI{CRIMIC.TG4.1}Gyf^{CR70565-TG4.1}/TI{GMR-HMS04515}Gat^eya

605321

y¹ w¹¹¹⁸; TI{TI}FRT101F Gyf^B/In(4)ci^D, ci^D pan^ciD

605793

y¹ w¹¹¹⁸; TI{TI}FRT101F Gyf^F/In(4)ci^D, ci^D pan^ciD

79256

y¹ w^*; TI{CRIMIC.TG4.1}Gyf^{CR00412-TG4.1}/In(4)ci^D, ci^D pan^ciD

97752

y¹ w¹¹¹⁸; TI{DH.1}Gyf^{CR70565-DH.PT-GFSTF.1}/In(4)ci^D, ci^D pan^ciD

Kyoto

119270

y¹ w¹¹¹⁸; TI{TI}FRT101F Gyf^B/In(4)ci^D, ci^D pan^ciD

VDRC

v105985

P{KK101931}VIE-260B

v18158

w¹¹¹⁸; P{GD7214}v18158

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (77)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039936

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039936

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kim et al., 2015)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Gyf CG11148

(Kim et al., 2015)

Nomenclature comments

Etymology

Named based on orthology to mammalian GIGYF1 and GIGYF2

(Kim et al., 2015)

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Name Synonyms

Gigyf

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43842

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KQM6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7KQM6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KQM6

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43842/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039936

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039936

FlyMine - An integrated database for Drosophila genomics

FBgn0039936

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11148

MARRVEL_MODEL - MARRVEL (model organism gene)

43842

PDB - An information portal to biological macromolecular structures

6S8R

Linkouts

BioGRID - A database of protein and genetic interactions.

68666

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039936

DroID - A comprehensive database of gene and protein interactions.

FBgn0039936

DRSC - Results frm RNAi screens

FBgn0039936

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG11148_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039936

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039936

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11148

Flygut - An atlas of the Drosophila adult midgut

FBgn0039936

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007086

MIST (protein-protein) - An integrated Molecular Interaction Database

43842

References (58)

The following external sites may use different assemblies or annotations than FlyBase.

-0.92

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