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Citation
Galindo, M.I., Bishop, S.A., Greig, S., Couso, J.P. (2002). Leg patterning driven by proximal-distal interactions and EGFR signaling.  Science 297(5579): 256--259.
FlyBase ID
FBrf0151488
Publication Type
Research paper
Abstract

wingless and decapentaplegic signaling establishes the proximal-distal axis of Drosophila legs by activating the expression of genes such as Distalless and dachshund in broad proximal-distal domains during early leg development. However, here we show that wingless and decapentaplegic are not required throughout all of proximal-distal development. The tarsus, which has been proposed to be an ancestral structure, is instead defined by the activity of Distalless, dachshund, and a distal gradient of epidermal growth factor receptor (EGFR)-Ras signaling. Our results uncover a mechanism for appendage patterning directed by genes expressed in proximal-distal domains and possibly conserved in other arthropods and vertebrates.

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Related Publication(s)
Note

Is that a fly in your leg?
Wells, 2002, J. Cell Biol. 158(4): 607 [FBrf0188713]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Alleles (12)
    Genes (16)
    Insertions (1)
    Transgenic Constructs (3)