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Citation
Linneweber, G.A., Jacobson, J., Busch, K.E., Hudry, B., Christov, C.P., Dormann, D., Yuan, M., Otani, T., Knust, E., de Bono, M., Miguel-Aliaga, I. (2014). Neuronal Control of Metabolism through Nutrient-Dependent Modulation of Tracheal Branching.  Cell 156(1-2): 69--83.
FlyBase ID
FBrf0223820
Publication Type
Research paper
Abstract

During adaptive angiogenesis, a key process in the etiology and treatment of cancer and obesity, the vasculature changes to meet the metabolic needs of its target tissues. Although the cues governing vascular remodeling are not fully understood, target-derived signals are generally believed to underlie this process. Here, we identify an alternative mechanism by characterizing the previously unrecognized nutrient-dependent plasticity of the Drosophila tracheal system: a network of oxygen-delivering tubules developmentally akin to mammalian blood vessels. We find that this plasticity, particularly prominent in the intestine, drives--rather than responds to--metabolic change. Mechanistically, it is regulated by distinct populations of nutrient- and oxygen-responsive neurons that, through delivery of both local and systemic insulin- and VIP-like neuropeptides, sculpt the growth of specific tracheal subsets. Thus, we describe a novel mechanism by which nutritional cues modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular architecture.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC3898607 (PMC) (EuropePMC)
Related Publication(s)
Note

Will branch for food-nutrient-dependent tracheal remodeling in Drosophila.
Marxreiter and Thummel, 2014, EMBO J. 33(3): 179--180 [FBrf0224040]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference